PMTM_ARATH
ID PMTM_ARATH Reviewed; 610 AA.
AC Q9LYN3;
DT 23-MAR-2010, integrated into UniProtKB/Swiss-Prot.
DT 01-OCT-2000, sequence version 1.
DT 03-AUG-2022, entry version 118.
DE RecName: Full=Probable methyltransferase PMT22;
DE EC=2.1.1.-;
GN OrderedLocusNames=At3g56080; ORFNames=F18O21.40;
OS Arabidopsis thaliana (Mouse-ear cress).
OC Eukaryota; Viridiplantae; Streptophyta; Embryophyta; Tracheophyta;
OC Spermatophyta; Magnoliopsida; eudicotyledons; Gunneridae; Pentapetalae;
OC rosids; malvids; Brassicales; Brassicaceae; Camelineae; Arabidopsis.
OX NCBI_TaxID=3702;
RN [1]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=cv. Columbia;
RX PubMed=11130713; DOI=10.1038/35048706;
RA Salanoubat M., Lemcke K., Rieger M., Ansorge W., Unseld M., Fartmann B.,
RA Valle G., Bloecker H., Perez-Alonso M., Obermaier B., Delseny M.,
RA Boutry M., Grivell L.A., Mache R., Puigdomenech P., De Simone V.,
RA Choisne N., Artiguenave F., Robert C., Brottier P., Wincker P.,
RA Cattolico L., Weissenbach J., Saurin W., Quetier F., Schaefer M.,
RA Mueller-Auer S., Gabel C., Fuchs M., Benes V., Wurmbach E., Drzonek H.,
RA Erfle H., Jordan N., Bangert S., Wiedelmann R., Kranz H., Voss H.,
RA Holland R., Brandt P., Nyakatura G., Vezzi A., D'Angelo M., Pallavicini A.,
RA Toppo S., Simionati B., Conrad A., Hornischer K., Kauer G., Loehnert T.-H.,
RA Nordsiek G., Reichelt J., Scharfe M., Schoen O., Bargues M., Terol J.,
RA Climent J., Navarro P., Collado C., Perez-Perez A., Ottenwaelder B.,
RA Duchemin D., Cooke R., Laudie M., Berger-Llauro C., Purnelle B., Masuy D.,
RA de Haan M., Maarse A.C., Alcaraz J.-P., Cottet A., Casacuberta E.,
RA Monfort A., Argiriou A., Flores M., Liguori R., Vitale D., Mannhaupt G.,
RA Haase D., Schoof H., Rudd S., Zaccaria P., Mewes H.-W., Mayer K.F.X.,
RA Kaul S., Town C.D., Koo H.L., Tallon L.J., Jenkins J., Rooney T., Rizzo M.,
RA Walts A., Utterback T., Fujii C.Y., Shea T.P., Creasy T.H., Haas B.,
RA Maiti R., Wu D., Peterson J., Van Aken S., Pai G., Militscher J.,
RA Sellers P., Gill J.E., Feldblyum T.V., Preuss D., Lin X., Nierman W.C.,
RA Salzberg S.L., White O., Venter J.C., Fraser C.M., Kaneko T., Nakamura Y.,
RA Sato S., Kato T., Asamizu E., Sasamoto S., Kimura T., Idesawa K.,
RA Kawashima K., Kishida Y., Kiyokawa C., Kohara M., Matsumoto M., Matsuno A.,
RA Muraki A., Nakayama S., Nakazaki N., Shinpo S., Takeuchi C., Wada T.,
RA Watanabe A., Yamada M., Yasuda M., Tabata S.;
RT "Sequence and analysis of chromosome 3 of the plant Arabidopsis thaliana.";
RL Nature 408:820-822(2000).
RN [2]
RP GENOME REANNOTATION.
RC STRAIN=cv. Columbia;
RX PubMed=27862469; DOI=10.1111/tpj.13415;
RA Cheng C.Y., Krishnakumar V., Chan A.P., Thibaud-Nissen F., Schobel S.,
RA Town C.D.;
RT "Araport11: a complete reannotation of the Arabidopsis thaliana reference
RT genome.";
RL Plant J. 89:789-804(2017).
RN [3]
RP GENE FAMILY.
RX PubMed=17461780; DOI=10.1111/j.1365-313x.2007.03123.x;
RA Krupkova E., Immerzeel P., Pauly M., Schmulling T.;
RT "The TUMOROUS SHOOT DEVELOPMENT2 gene of Arabidopsis encoding a putative
RT methyltransferase is required for cell adhesion and co-ordinated plant
RT development.";
RL Plant J. 50:735-750(2007).
CC -!- SUBCELLULAR LOCATION: Endoplasmic reticulum membrane {ECO:0000305};
CC Single-pass type II membrane protein {ECO:0000305}.
CC -!- SIMILARITY: Belongs to the methyltransferase superfamily.
CC {ECO:0000305}.
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DR EMBL; AL163763; CAB87407.1; -; Genomic_DNA.
DR EMBL; CP002686; AEE79475.1; -; Genomic_DNA.
DR PIR; T47725; T47725.
DR RefSeq; NP_567033.2; NM_115466.5.
DR AlphaFoldDB; Q9LYN3; -.
DR STRING; 3702.AT3G56080.1; -.
DR MetOSite; Q9LYN3; -.
DR PaxDb; Q9LYN3; -.
DR PRIDE; Q9LYN3; -.
DR ProteomicsDB; 234747; -.
DR EnsemblPlants; AT3G56080.1; AT3G56080.1; AT3G56080.
DR GeneID; 824774; -.
DR Gramene; AT3G56080.1; AT3G56080.1; AT3G56080.
DR KEGG; ath:AT3G56080; -.
DR Araport; AT3G56080; -.
DR TAIR; locus:2078466; AT3G56080.
DR eggNOG; ENOG502QQAS; Eukaryota.
DR HOGENOM; CLU_010485_2_2_1; -.
DR InParanoid; Q9LYN3; -.
DR OMA; CDLMEVV; -.
DR OrthoDB; 465444at2759; -.
DR PhylomeDB; Q9LYN3; -.
DR PRO; PR:Q9LYN3; -.
DR Proteomes; UP000006548; Chromosome 3.
DR ExpressionAtlas; Q9LYN3; baseline and differential.
DR Genevisible; Q9LYN3; AT.
DR GO; GO:0005737; C:cytoplasm; IBA:GO_Central.
DR GO; GO:0005789; C:endoplasmic reticulum membrane; IEA:UniProtKB-SubCell.
DR GO; GO:0016021; C:integral component of membrane; IEA:UniProtKB-KW.
DR GO; GO:0008168; F:methyltransferase activity; IEA:UniProtKB-KW.
DR GO; GO:0032259; P:methylation; IEA:UniProtKB-KW.
DR Gene3D; 3.40.50.150; -; 1.
DR InterPro; IPR004159; Put_SAM_MeTrfase.
DR InterPro; IPR029063; SAM-dependent_MTases_sf.
DR PANTHER; PTHR10108; PTHR10108; 1.
DR Pfam; PF03141; Methyltransf_29; 1.
DR SUPFAM; SSF53335; SSF53335; 2.
PE 3: Inferred from homology;
KW Endoplasmic reticulum; Glycoprotein; Membrane; Methyltransferase;
KW Reference proteome; Signal-anchor; Transferase; Transmembrane;
KW Transmembrane helix.
FT CHAIN 1..610
FT /note="Probable methyltransferase PMT22"
FT /id="PRO_0000393262"
FT TOPO_DOM 1..10
FT /note="Cytoplasmic"
FT /evidence="ECO:0000255"
FT TRANSMEM 11..31
FT /note="Helical; Signal-anchor for type II membrane protein"
FT /evidence="ECO:0000255"
FT TOPO_DOM 32..610
FT /note="Lumenal"
FT /evidence="ECO:0000255"
FT REGION 56..81
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 56..74
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT CARBOHYD 64
FT /note="N-linked (GlcNAc...) asparagine"
FT /evidence="ECO:0000255"
FT CARBOHYD 75
FT /note="N-linked (GlcNAc...) asparagine"
FT /evidence="ECO:0000255"
FT CARBOHYD 100
FT /note="N-linked (GlcNAc...) asparagine"
FT /evidence="ECO:0000255"
FT CARBOHYD 400
FT /note="N-linked (GlcNAc...) asparagine"
FT /evidence="ECO:0000255"
FT CARBOHYD 469
FT /note="N-linked (GlcNAc...) asparagine"
FT /evidence="ECO:0000255"
FT CARBOHYD 546
FT /note="N-linked (GlcNAc...) asparagine"
FT /evidence="ECO:0000255"
SQ SEQUENCE 610 AA; 69992 MW; 461DA96E7C832245 CRC64;
MIKNIFQSRK LSGLCVLSIL LVSVTILLLT NDTIDLFPYL SLPYLPRSSL SVIPTSTPIS
SPTNDSSPPL ESPVNQTRVD DHPDDQGLEL DWLKDDKQWN VSLKIDWKRC ESPDYIPCLD
NTKAIKKLKS KRNMEHRERH CPERSPKCLV PLPQHYKVPL PWPQSRDMIW YDNVPHPKLV
EYKKDQNWVR KSGPFFVFPG GGTQFKDGVI HYINFIQKTL PILDWGKKVR VVLDVGCGVA
SFGGTLLDKN VITMSFAPKD EHEAQIQFAL ERGIPATLAV IGTQKLPFPD NAYDVIHCAR
CRVHWHGYGG RPLLELNRVL RPGGFFVWSA TPVYQHDEGH RNVWKTMESL TTSMCWKVVA
RTRFTKVGFV IYQKPDSDSC YESRKNKDPP LCIEEETKKN SSWYTPLLTC LPKLPVSPIG
KWPSGWPERL TETPVSLFRE QRSEESFRED SKLWSGVMSN IYLYSLAINW TRIHNVMDMN
AGYGGFAAAL INKPLWVMNV IPVEGEDTLS TIFDRGLIGI YHDWCESFNT YPRSYDLLHS
SFLFTNLSQR CDLMEVVVEI DRILRPGGYL AVQDTVEMLK KLNPILLSLR WSTNLYRGKF
LVGLKSSWRP
