ID   PNC2A_XENLA             Reviewed;         135 AA.
AC   Q66KH8;
DT   16-JUN-2009, integrated into UniProtKB/Swiss-Prot.
DT   11-OCT-2004, sequence version 1.
DT   03-AUG-2022, entry version 50.
DE   RecName: Full=Proline-rich nuclear receptor coactivator 2 A;
GN   Name=pnrc2-a;
OS   Xenopus laevis (African clawed frog).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Amphibia;
OC   Batrachia; Anura; Pipoidea; Pipidae; Xenopodinae; Xenopus; Xenopus.
OX   NCBI_TaxID=8355;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
RC   TISSUE=Kidney;
RG   NIH - Xenopus Gene Collection (XGC) project;
RL   Submitted (AUG-2004) to the EMBL/GenBank/DDBJ databases.
CC   -!- FUNCTION: Involved in nonsense-mediated mRNA decay (NMD) by acting as a
CC       bridge between the mRNA decapping complex and the NMD machinery. May
CC       act by targeting the NMD machinery to the P-body and recruiting the
CC       decapping machinery to aberrant mRNAs. Required for upf1/rent1
CC       localization to the P-body. Also acts as a nuclear receptor coactivator
CC       (By similarity). {ECO:0000250}.
CC   -!- SUBCELLULAR LOCATION: Nucleus {ECO:0000250}. Cytoplasm, P-body
CC       {ECO:0000250}.
CC   -!- SIMILARITY: Belongs to the PNRC family. PNRC2 subfamily. {ECO:0000305}.
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DR   EMBL; BC080387; AAH80387.1; -; mRNA.
DR   RefSeq; NP_001087586.1; NM_001094117.1.
DR   AlphaFoldDB; Q66KH8; -.
DR   DNASU; 447410; -.
DR   GeneID; 447410; -.
DR   KEGG; xla:447410; -.
DR   CTD; 447410; -.
DR   Xenbase; XB-GENE-865957; pnrc2.L.
DR   OrthoDB; 1570409at2759; -.
DR   Proteomes; UP000186698; Chromosome 2L.
DR   Bgee; 447410; Expressed in blastula and 19 other tissues.
DR   GO; GO:0005634; C:nucleus; ISS:UniProtKB.
DR   GO; GO:0000932; C:P-body; ISS:UniProtKB.
DR   GO; GO:0000184; P:nuclear-transcribed mRNA catabolic process, nonsense-mediated decay; ISS:UniProtKB.
DR   InterPro; IPR026780; PNRC1/2.
DR   InterPro; IPR026781; PNRC2.
DR   PANTHER; PTHR15405; PTHR15405; 1.
DR   PANTHER; PTHR15405:SF6; PTHR15405:SF6; 1.
PE   2: Evidence at transcript level;
KW   Activator; Cytoplasm; Nonsense-mediated mRNA decay; Nucleus;
KW   Reference proteome; Transcription; Transcription regulation.
FT   CHAIN           1..135
FT                   /note="Proline-rich nuclear receptor coactivator 2 A"
FT                   /id="PRO_0000377566"
FT   REGION          1..46
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   MOTIF           95..101
FT                   /note="SH3-binding"
FT   COMPBIAS        13..33
FT                   /note="Polar residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ   SEQUENCE   135 AA;  15015 MW;  2DAC61C58BCEC223 CRC64;
     MGGGERFNIP GQHRNNLGKQ INRQKLFDRN NQKMNTSHTK DRGRGCGTSL AWQAMQNGIN
     NNAFSPNQNW SAGFPASKNL FTDEDNQNYA GAKFSEPPSP SVLPKPPSHW VLLSCSPAEK
     ELMSFQLKTL LKVQA