PNCC_SHIFL
ID PNCC_SHIFL Reviewed; 165 AA.
AC Q83JZ0;
DT 25-JUL-2003, integrated into UniProtKB/Swiss-Prot.
DT 25-JUL-2003, sequence version 2.
DT 25-MAY-2022, entry version 97.
DE RecName: Full=Nicotinamide-nucleotide amidohydrolase PncC;
DE Short=NMN amidohydrolase PncC;
DE EC=3.5.1.42;
DE AltName: Full=NMN deamidase;
DE AltName: Full=Nicotinamide-nucleotide amidase;
GN Name=pncC; OrderedLocusNames=SF2723, S2914;
OS Shigella flexneri.
OC Bacteria; Proteobacteria; Gammaproteobacteria; Enterobacterales;
OC Enterobacteriaceae; Shigella.
OX NCBI_TaxID=623;
RN [1]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=301 / Serotype 2a;
RX PubMed=12384590; DOI=10.1093/nar/gkf566;
RA Jin Q., Yuan Z., Xu J., Wang Y., Shen Y., Lu W., Wang J., Liu H., Yang J.,
RA Yang F., Zhang X., Zhang J., Yang G., Wu H., Qu D., Dong J., Sun L.,
RA Xue Y., Zhao A., Gao Y., Zhu J., Kan B., Ding K., Chen S., Cheng H.,
RA Yao Z., He B., Chen R., Ma D., Qiang B., Wen Y., Hou Y., Yu J.;
RT "Genome sequence of Shigella flexneri 2a: insights into pathogenicity
RT through comparison with genomes of Escherichia coli K12 and O157.";
RL Nucleic Acids Res. 30:4432-4441(2002).
RN [2]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=ATCC 700930 / 2457T / Serotype 2a;
RX PubMed=12704152; DOI=10.1128/iai.71.5.2775-2786.2003;
RA Wei J., Goldberg M.B., Burland V., Venkatesan M.M., Deng W., Fournier G.,
RA Mayhew G.F., Plunkett G. III, Rose D.J., Darling A., Mau B., Perna N.T.,
RA Payne S.M., Runyen-Janecky L.J., Zhou S., Schwartz D.C., Blattner F.R.;
RT "Complete genome sequence and comparative genomics of Shigella flexneri
RT serotype 2a strain 2457T.";
RL Infect. Immun. 71:2775-2786(2003).
CC -!- FUNCTION: Has NMN aminohydrolase activity, not active on other
CC substrates. {ECO:0000250}.
CC -!- CATALYTIC ACTIVITY:
CC Reaction=beta-nicotinamide D-ribonucleotide + H2O = NH4(+) + nicotinate
CC beta-D-ribonucleotide; Xref=Rhea:RHEA:12400, ChEBI:CHEBI:14649,
CC ChEBI:CHEBI:15377, ChEBI:CHEBI:28938, ChEBI:CHEBI:57502; EC=3.5.1.42;
CC -!- SUBUNIT: Homodimer. {ECO:0000250}.
CC -!- SIMILARITY: Belongs to the CinA family. PncC subfamily. {ECO:0000305}.
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DR EMBL; AE005674; AAN44215.2; -; Genomic_DNA.
DR EMBL; AE014073; AAP18041.1; -; Genomic_DNA.
DR RefSeq; NP_708508.2; NC_004337.2.
DR AlphaFoldDB; Q83JZ0; -.
DR SMR; Q83JZ0; -.
DR STRING; 198214.SF2723; -.
DR PRIDE; Q83JZ0; -.
DR EnsemblBacteria; AAN44215; AAN44215; SF2723.
DR EnsemblBacteria; AAP18041; AAP18041; S2914.
DR GeneID; 1025712; -.
DR KEGG; sfl:SF2723; -.
DR KEGG; sfx:S2914; -.
DR PATRIC; fig|198214.7.peg.3243; -.
DR HOGENOM; CLU_030805_1_1_6; -.
DR Proteomes; UP000001006; Chromosome.
DR Proteomes; UP000002673; Chromosome.
DR GO; GO:0019159; F:nicotinamide-nucleotide amidase activity; IEA:UniProtKB-EC.
DR GO; GO:0019363; P:pyridine nucleotide biosynthetic process; IEA:UniProtKB-KW.
DR Gene3D; 3.90.950.20; -; 1.
DR InterPro; IPR036653; CinA-like_C.
DR InterPro; IPR008136; CinA_C.
DR Pfam; PF02464; CinA; 1.
DR SUPFAM; SSF142433; SSF142433; 1.
DR TIGRFAMs; TIGR00199; PncC_domain; 1.
PE 3: Inferred from homology;
KW Hydrolase; Pyridine nucleotide biosynthesis; Reference proteome.
FT CHAIN 1..165
FT /note="Nicotinamide-nucleotide amidohydrolase PncC"
FT /id="PRO_0000156793"
FT CONFLICT 134
FT /note="W -> R (in Ref. 2; AAP18041)"
FT /evidence="ECO:0000305"
SQ SEQUENCE 165 AA; 17612 MW; EC1D31D25D5DE217 CRC64;
MTDSELMQLS EQVGQALKAR GATVTTAESC TGGWVAKVIT DIAGSSAWFE RGFVTYSNEA
KAQMIGVREE TLAQHGAVSE PVVVEMAIGA LKAARADYAV SISGIAGPDG GSEEKPVGTV
WFAFATARGE GITWRECFSG DRDAVRRQAT AYALQTLWQQ FLQNT
