ID   PNDA2_ECOLX             Reviewed;          50 AA.
AC   P16477;
DT   01-AUG-1990, integrated into UniProtKB/Swiss-Prot.
DT   01-AUG-1990, sequence version 1.
DT   25-MAY-2022, entry version 93.
DE   RecName: Full=Protein PndA;
GN   Name=pndA; Synonyms=pnd;
OS   Escherichia coli.
OG   Plasmid IncI1 R483.
OC   Bacteria; Proteobacteria; Gammaproteobacteria; Enterobacterales;
OC   Enterobacteriaceae; Escherichia.
OX   NCBI_TaxID=562;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [GENOMIC DNA].
RX   PubMed=3328043; DOI=10.1111/j.1348-0421.1987.tb01339.x;
RA   Ono K., Akimoto S., Ohnishi Y.;
RT   "Nucleotide sequence of the pnd gene in plasmid R483 and role of the pnd
RT   gene product in plasmolysis.";
RL   Microbiol. Immunol. 31:1071-1083(1987).
CC   -!- FUNCTION: Toxic component of a type I toxin-antitoxin (TA) system (By
CC       similarity). When expressed is involved in cellular Mg(2+) release and
CC       degradation of stable RNA (PubMed:3328043).
CC       {ECO:0000250|UniProtKB:P0ACG4, ECO:0000269|PubMed:3328043}.
CC   -!- SUBCELLULAR LOCATION: Cell inner membrane
CC       {ECO:0000250|UniProtKB:P0ACG4}; Single-pass membrane protein
CC       {ECO:0000305}.
CC   -!- SIMILARITY: Belongs to the Hok/Gef family. {ECO:0000305}.
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DR   EMBL; D00364; BAA00270.1; -; Genomic_DNA.
DR   PIR; JU0071; JU0071.
DR   RefSeq; WP_001331364.1; NZ_WVVP01000033.1.
DR   RefSeq; YP_009061145.1; NC_024975.1.
DR   AlphaFoldDB; P16477; -.
DR   SMR; P16477; -.
DR   GeneID; 60904360; -.
DR   GO; GO:0016021; C:integral component of membrane; IEA:UniProtKB-KW.
DR   GO; GO:0005886; C:plasma membrane; IEA:UniProtKB-SubCell.
DR   InterPro; IPR000021; Hok/gef_toxin.
DR   InterPro; IPR018084; Hok/gef_toxin_CS.
DR   Pfam; PF01848; HOK_GEF; 1.
DR   PRINTS; PR00281; HOKGEFTOXIC.
DR   PROSITE; PS00556; HOK_GEF; 1.
PE   3: Inferred from homology;
KW   Cell inner membrane; Cell membrane; Membrane; Plasmid;
KW   Toxin-antitoxin system; Transmembrane; Transmembrane helix.
FT   CHAIN           1..50
FT                   /note="Protein PndA"
FT                   /id="PRO_0000199044"
FT   TRANSMEM        5..25
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
SQ   SEQUENCE   50 AA;  5775 MW;  2DA904CDCE81AFA9 CRC64;
     MPQRTFLMML IVICVTILCF VWMVRDSLCG LRLQQGNTVL VATLAYEVKR