PNG1_GIBZE
ID PNG1_GIBZE Reviewed; 451 AA.
AC Q4IR87; A0A0E0RLP1; V6R0L4;
DT 05-SEP-2006, integrated into UniProtKB/Swiss-Prot.
DT 16-AUG-2005, sequence version 1.
DT 03-AUG-2022, entry version 83.
DE RecName: Full=Protein PNG1;
GN Name=PNG1; ORFNames=FGRRES_00271, FGSG_00271;
OS Gibberella zeae (strain ATCC MYA-4620 / CBS 123657 / FGSC 9075 / NRRL 31084
OS / PH-1) (Wheat head blight fungus) (Fusarium graminearum).
OC Eukaryota; Fungi; Dikarya; Ascomycota; Pezizomycotina; Sordariomycetes;
OC Hypocreomycetidae; Hypocreales; Nectriaceae; Fusarium.
OX NCBI_TaxID=229533;
RN [1]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=ATCC MYA-4620 / CBS 123657 / FGSC 9075 / NRRL 31084 / PH-1;
RX PubMed=17823352; DOI=10.1126/science.1143708;
RA Cuomo C.A., Gueldener U., Xu J.-R., Trail F., Turgeon B.G., Di Pietro A.,
RA Walton J.D., Ma L.-J., Baker S.E., Rep M., Adam G., Antoniw J., Baldwin T.,
RA Calvo S.E., Chang Y.-L., DeCaprio D., Gale L.R., Gnerre S., Goswami R.S.,
RA Hammond-Kosack K., Harris L.J., Hilburn K., Kennell J.C., Kroken S.,
RA Magnuson J.K., Mannhaupt G., Mauceli E.W., Mewes H.-W., Mitterbauer R.,
RA Muehlbauer G., Muensterkoetter M., Nelson D., O'Donnell K., Ouellet T.,
RA Qi W., Quesneville H., Roncero M.I.G., Seong K.-Y., Tetko I.V., Urban M.,
RA Waalwijk C., Ward T.J., Yao J., Birren B.W., Kistler H.C.;
RT "The Fusarium graminearum genome reveals a link between localized
RT polymorphism and pathogen specialization.";
RL Science 317:1400-1402(2007).
RN [2]
RP GENOME REANNOTATION.
RC STRAIN=ATCC MYA-4620 / CBS 123657 / FGSC 9075 / NRRL 31084 / PH-1;
RX PubMed=20237561; DOI=10.1038/nature08850;
RA Ma L.-J., van der Does H.C., Borkovich K.A., Coleman J.J., Daboussi M.-J.,
RA Di Pietro A., Dufresne M., Freitag M., Grabherr M., Henrissat B.,
RA Houterman P.M., Kang S., Shim W.-B., Woloshuk C., Xie X., Xu J.-R.,
RA Antoniw J., Baker S.E., Bluhm B.H., Breakspear A., Brown D.W.,
RA Butchko R.A.E., Chapman S., Coulson R., Coutinho P.M., Danchin E.G.J.,
RA Diener A., Gale L.R., Gardiner D.M., Goff S., Hammond-Kosack K.E.,
RA Hilburn K., Hua-Van A., Jonkers W., Kazan K., Kodira C.D., Koehrsen M.,
RA Kumar L., Lee Y.-H., Li L., Manners J.M., Miranda-Saavedra D.,
RA Mukherjee M., Park G., Park J., Park S.-Y., Proctor R.H., Regev A.,
RA Ruiz-Roldan M.C., Sain D., Sakthikumar S., Sykes S., Schwartz D.C.,
RA Turgeon B.G., Wapinski I., Yoder O., Young S., Zeng Q., Zhou S.,
RA Galagan J., Cuomo C.A., Kistler H.C., Rep M.;
RT "Comparative genomics reveals mobile pathogenicity chromosomes in
RT Fusarium.";
RL Nature 464:367-373(2010).
RN [3]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=ATCC MYA-4620 / CBS 123657 / FGSC 9075 / NRRL 31084 / PH-1;
RX PubMed=26198851; DOI=10.1186/s12864-015-1756-1;
RA King R., Urban M., Hammond-Kosack M.C.U., Hassani-Pak K.,
RA Hammond-Kosack K.E.;
RT "The completed genome sequence of the pathogenic ascomycete fungus Fusarium
RT graminearum.";
RL BMC Genomics 16:544-544(2015).
CC -!- SIMILARITY: Belongs to the transglutaminase-like superfamily. PNGase
CC family. {ECO:0000305}.
CC -!- CAUTION: Although strongly related to the peptide:N-glycanase enzyme,
CC it lacks the conserved active site Cys in position 243, which is
CC replaced by a Val residue suggesting that it has no activity.
CC {ECO:0000305}.
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DR EMBL; DS231663; ESU05430.1; -; Genomic_DNA.
DR EMBL; HG970332; CEF72166.1; -; Genomic_DNA.
DR RefSeq; XP_011315915.1; XM_011317613.1.
DR AlphaFoldDB; Q4IR87; -.
DR SMR; Q4IR87; -.
DR STRING; 5518.FGSG_00271P0; -.
DR PRIDE; Q4IR87; -.
DR EnsemblFungi; ESU05430; ESU05430; FGSG_00271.
DR GeneID; 23547764; -.
DR KEGG; fgr:FGSG_00271; -.
DR VEuPathDB; FungiDB:FGRAMPH1_01G00729; -.
DR eggNOG; KOG0909; Eukaryota.
DR HOGENOM; CLU_031058_1_0_1; -.
DR InParanoid; Q4IR87; -.
DR Proteomes; UP000070720; Chromosome 1.
DR GO; GO:0046872; F:metal ion binding; IEA:UniProtKB-KW.
DR GO; GO:0006950; P:response to stress; IEA:UniProt.
DR InterPro; IPR038765; Papain-like_cys_pep_sf.
DR InterPro; IPR018325; Rad4/PNGase_transGLS-fold.
DR InterPro; IPR002931; Transglutaminase-like.
DR Pfam; PF03835; Rad4; 1.
DR SMART; SM00460; TGc; 1.
DR SUPFAM; SSF54001; SSF54001; 1.
PE 3: Inferred from homology;
KW Metal-binding; Reference proteome; Zinc.
FT CHAIN 1..451
FT /note="Protein PNG1"
FT /id="PRO_0000248991"
FT REGION 30..73
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 391..451
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 37..69
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 394..439
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT BINDING 183
FT /ligand="Zn(2+)"
FT /ligand_id="ChEBI:CHEBI:29105"
FT /evidence="ECO:0000250"
FT BINDING 186
FT /ligand="Zn(2+)"
FT /ligand_id="ChEBI:CHEBI:29105"
FT /evidence="ECO:0000250"
FT BINDING 215
FT /ligand="Zn(2+)"
FT /ligand_id="ChEBI:CHEBI:29105"
FT /evidence="ECO:0000250"
FT BINDING 220
FT /ligand="Zn(2+)"
FT /ligand_id="ChEBI:CHEBI:29105"
FT /evidence="ECO:0000250"
SQ SEQUENCE 451 AA; 51335 MW; 6694DFC9F60679EA CRC64;
MAGQHPPAGE YGEEWARDLR VQFEGLLRDK RMNDLRNTSR QSSPSLGDQS PHMRSSPFPS
DNRPSGSQGP ALPSYAALRH LPKIPSPPAA GDRDSQKFRN LLISLSLTPT KYENPGLLDE
ALQTIPLDRI YGEAEEETQV LQAQAESMGD GRKPEWGYQD CVIRALLRWF KRSFFSWVNN
PPCPSCLSPT IAQGMTAPTP EESACGALRV ELYRCSAQHC GAYERFPRYG DVWRLLQTRR
GRVGEWANCF SMLCRAVGGR VRWVWNAEDH VWTEVYSDHQ KRWVHVDACE EAWDNPRLYA
EGWGKKMSYC IAFSIDGATD VTRRYVRKNQ HASERNRCPE EVLLYVMQEI KNMRRSNMNK
DERFRLEKED TREDKELRGY VVASIAQAVT DLVPGSPGGS NHTTASGSDT KLPAEQPGRQ
TGTSEWLTAQ QQQSHSRYQQ PRDPSHRRPL P
