PNM8A_HUMAN
ID PNM8A_HUMAN Reviewed; 439 AA.
AC Q86V59; A8K2F3; Q5U638; Q8N3H4; Q9NVE8;
DT 18-MAR-2008, integrated into UniProtKB/Swiss-Prot.
DT 07-DEC-2004, sequence version 2.
DT 03-AUG-2022, entry version 129.
DE RecName: Full=Paraneoplastic antigen-like protein 8A {ECO:0000312|HGNC:HGNC:25578};
DE AltName: Full=PNMA-like protein 1;
GN Name=PNMA8A {ECO:0000312|HGNC:HGNC:25578}; Synonyms=PNMAL1;
OS Homo sapiens (Human).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae;
OC Homo.
OX NCBI_TaxID=9606;
RN [1]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 2).
RC TISSUE=Amygdala;
RX PubMed=17974005; DOI=10.1186/1471-2164-8-399;
RA Bechtel S., Rosenfelder H., Duda A., Schmidt C.P., Ernst U.,
RA Wellenreuther R., Mehrle A., Schuster C., Bahr A., Bloecker H., Heubner D.,
RA Hoerlein A., Michel G., Wedler H., Koehrer K., Ottenwaelder B., Poustka A.,
RA Wiemann S., Schupp I.;
RT "The full-ORF clone resource of the German cDNA consortium.";
RL BMC Genomics 8:399-399(2007).
RN [2]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RA Mural R.J., Istrail S., Sutton G.G., Florea L., Halpern A.L., Mobarry C.M.,
RA Lippert R., Walenz B., Shatkay H., Dew I., Miller J.R., Flanigan M.J.,
RA Edwards N.J., Bolanos R., Fasulo D., Halldorsson B.V., Hannenhalli S.,
RA Turner R., Yooseph S., Lu F., Nusskern D.R., Shue B.C., Zheng X.H.,
RA Zhong F., Delcher A.L., Huson D.H., Kravitz S.A., Mouchard L., Reinert K.,
RA Remington K.A., Clark A.G., Waterman M.S., Eichler E.E., Adams M.D.,
RA Hunkapiller M.W., Myers E.W., Venter J.C.;
RL Submitted (JUL-2005) to the EMBL/GenBank/DDBJ databases.
RN [3]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 1).
RC TISSUE=Fetal brain, Neuroblastoma, and Testis;
RX PubMed=15489334; DOI=10.1101/gr.2596504;
RG The MGC Project Team;
RT "The status, quality, and expansion of the NIH full-length cDNA project:
RT the Mammalian Gene Collection (MGC).";
RL Genome Res. 14:2121-2127(2004).
RN [4]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] OF 1-173 AND 195-439 (ISOFORM 1).
RC TISSUE=Thalamus;
RX PubMed=14702039; DOI=10.1038/ng1285;
RA Ota T., Suzuki Y., Nishikawa T., Otsuki T., Sugiyama T., Irie R.,
RA Wakamatsu A., Hayashi K., Sato H., Nagai K., Kimura K., Makita H.,
RA Sekine M., Obayashi M., Nishi T., Shibahara T., Tanaka T., Ishii S.,
RA Yamamoto J., Saito K., Kawai Y., Isono Y., Nakamura Y., Nagahari K.,
RA Murakami K., Yasuda T., Iwayanagi T., Wagatsuma M., Shiratori A., Sudo H.,
RA Hosoiri T., Kaku Y., Kodaira H., Kondo H., Sugawara M., Takahashi M.,
RA Kanda K., Yokoi T., Furuya T., Kikkawa E., Omura Y., Abe K., Kamihara K.,
RA Katsuta N., Sato K., Tanikawa M., Yamazaki M., Ninomiya K., Ishibashi T.,
RA Yamashita H., Murakawa K., Fujimori K., Tanai H., Kimata M., Watanabe M.,
RA Hiraoka S., Chiba Y., Ishida S., Ono Y., Takiguchi S., Watanabe S.,
RA Yosida M., Hotuta T., Kusano J., Kanehori K., Takahashi-Fujii A., Hara H.,
RA Tanase T.-O., Nomura Y., Togiya S., Komai F., Hara R., Takeuchi K.,
RA Arita M., Imose N., Musashino K., Yuuki H., Oshima A., Sasaki N.,
RA Aotsuka S., Yoshikawa Y., Matsunawa H., Ichihara T., Shiohata N., Sano S.,
RA Moriya S., Momiyama H., Satoh N., Takami S., Terashima Y., Suzuki O.,
RA Nakagawa S., Senoh A., Mizoguchi H., Goto Y., Shimizu F., Wakebe H.,
RA Hishigaki H., Watanabe T., Sugiyama A., Takemoto M., Kawakami B.,
RA Yamazaki M., Watanabe K., Kumagai A., Itakura S., Fukuzumi Y., Fujimori Y.,
RA Komiyama M., Tashiro H., Tanigami A., Fujiwara T., Ono T., Yamada K.,
RA Fujii Y., Ozaki K., Hirao M., Ohmori Y., Kawabata A., Hikiji T.,
RA Kobatake N., Inagaki H., Ikema Y., Okamoto S., Okitani R., Kawakami T.,
RA Noguchi S., Itoh T., Shigeta K., Senba T., Matsumura K., Nakajima Y.,
RA Mizuno T., Morinaga M., Sasaki M., Togashi T., Oyama M., Hata H.,
RA Watanabe M., Komatsu T., Mizushima-Sugano J., Satoh T., Shirai Y.,
RA Takahashi Y., Nakagawa K., Okumura K., Nagase T., Nomura N., Kikuchi H.,
RA Masuho Y., Yamashita R., Nakai K., Yada T., Nakamura Y., Ohara O.,
RA Isogai T., Sugano S.;
RT "Complete sequencing and characterization of 21,243 full-length human
RT cDNAs.";
RL Nat. Genet. 36:40-45(2004).
RN [5]
RP IDENTIFICATION.
RX PubMed=16550607; DOI=10.1002/ijc.21901;
RA Tews B., Felsberg J., Hartmann C., Kunitz A., Hahn M., Toedt G., Neben K.,
RA Hummerich L., von Deimling A., Reifenberger G., Lichter P.;
RT "Identification of novel oligodendroglioma-associated candidate tumor
RT suppressor genes in 1p36 and 19q13 using microarray-based expression
RT profiling.";
RL Int. J. Cancer 119:792-800(2006).
RN [6]
RP IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
RX PubMed=21269460; DOI=10.1186/1752-0509-5-17;
RA Burkard T.R., Planyavsky M., Kaupe I., Breitwieser F.P., Buerckstuemmer T.,
RA Bennett K.L., Superti-Furga G., Colinge J.;
RT "Initial characterization of the human central proteome.";
RL BMC Syst. Biol. 5:17-17(2011).
RN [7]
RP IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
RC TISSUE=Erythroleukemia;
RX PubMed=23186163; DOI=10.1021/pr300630k;
RA Zhou H., Di Palma S., Preisinger C., Peng M., Polat A.N., Heck A.J.,
RA Mohammed S.;
RT "Toward a comprehensive characterization of a human cancer cell
RT phosphoproteome.";
RL J. Proteome Res. 12:260-271(2013).
CC -!- ALTERNATIVE PRODUCTS:
CC Event=Alternative splicing; Named isoforms=2;
CC Name=1;
CC IsoId=Q86V59-1; Sequence=Displayed;
CC Name=2;
CC IsoId=Q86V59-2; Sequence=VSP_032441, VSP_032442;
CC -!- SIMILARITY: Belongs to the PNMA family. {ECO:0000305}.
CC -!- SEQUENCE CAUTION:
CC Sequence=BAA91804.1; Type=Erroneous initiation; Note=Truncated N-terminus.; Evidence={ECO:0000305};
CC Sequence=BAF82907.1; Type=Erroneous translation; Note=Wrong choice of CDS.; Evidence={ECO:0000305};
CC Sequence=BAF82907.1; Type=Miscellaneous discrepancy; Note=Probable cloning artifact. Aberrant splice sites.; Evidence={ECO:0000305};
CC Sequence=EAW57420.1; Type=Erroneous initiation; Note=Truncated N-terminus.; Evidence={ECO:0000305};
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DR EMBL; AL834344; CAD39010.1; -; mRNA.
DR EMBL; CH471126; EAW57420.1; ALT_INIT; Genomic_DNA.
DR EMBL; CH471126; EAW57421.1; -; Genomic_DNA.
DR EMBL; BC026026; AAH26026.2; -; mRNA.
DR EMBL; BC032508; AAH32508.1; -; mRNA.
DR EMBL; BC051688; AAH51688.2; -; mRNA.
DR EMBL; AK001643; BAA91804.1; ALT_INIT; mRNA.
DR EMBL; AK290218; BAF82907.1; ALT_SEQ; mRNA.
DR CCDS; CCDS33059.1; -. [Q86V59-1]
DR CCDS; CCDS46124.1; -. [Q86V59-2]
DR RefSeq; NP_001096619.1; NM_001103149.1. [Q86V59-2]
DR RefSeq; NP_060685.2; NM_018215.3. [Q86V59-1]
DR AlphaFoldDB; Q86V59; -.
DR BioGRID; 120523; 119.
DR IntAct; Q86V59; 5.
DR STRING; 9606.ENSP00000318131; -.
DR iPTMnet; Q86V59; -.
DR PhosphoSitePlus; Q86V59; -.
DR BioMuta; PNMA8A; -.
DR DMDM; 74727539; -.
DR EPD; Q86V59; -.
DR jPOST; Q86V59; -.
DR MassIVE; Q86V59; -.
DR MaxQB; Q86V59; -.
DR PaxDb; Q86V59; -.
DR PeptideAtlas; Q86V59; -.
DR PRIDE; Q86V59; -.
DR ProteomicsDB; 69969; -. [Q86V59-1]
DR ProteomicsDB; 69970; -. [Q86V59-2]
DR Antibodypedia; 2037; 56 antibodies from 20 providers.
DR DNASU; 55228; -.
DR Ensembl; ENST00000313683.15; ENSP00000318131.10; ENSG00000182013.18. [Q86V59-1]
DR Ensembl; ENST00000438932.2; ENSP00000410273.1; ENSG00000182013.18. [Q86V59-2]
DR GeneID; 55228; -.
DR KEGG; hsa:55228; -.
DR MANE-Select; ENST00000313683.15; ENSP00000318131.10; NM_018215.4; NP_060685.2.
DR UCSC; uc002peq.5; human. [Q86V59-1]
DR CTD; 55228; -.
DR GeneCards; PNMA8A; -.
DR HGNC; HGNC:25578; PNMA8A.
DR HPA; ENSG00000182013; Tissue enhanced (brain).
DR neXtProt; NX_Q86V59; -.
DR OpenTargets; ENSG00000182013; -.
DR PharmGKB; PA162399835; -.
DR VEuPathDB; HostDB:ENSG00000182013; -.
DR eggNOG; ENOG502TEDX; Eukaryota.
DR GeneTree; ENSGT01030000234522; -.
DR HOGENOM; CLU_050538_0_0_1; -.
DR InParanoid; Q86V59; -.
DR OMA; WEDVVHL; -.
DR OrthoDB; 820525at2759; -.
DR PhylomeDB; Q86V59; -.
DR TreeFam; TF335054; -.
DR PathwayCommons; Q86V59; -.
DR SignaLink; Q86V59; -.
DR BioGRID-ORCS; 55228; 9 hits in 1072 CRISPR screens.
DR ChiTaRS; PNMAL1; human.
DR GeneWiki; FLJ10781; -.
DR GenomeRNAi; 55228; -.
DR Pharos; Q86V59; Tdark.
DR PRO; PR:Q86V59; -.
DR Proteomes; UP000005640; Chromosome 19.
DR RNAct; Q86V59; protein.
DR Bgee; ENSG00000182013; Expressed in endothelial cell and 174 other tissues.
DR ExpressionAtlas; Q86V59; baseline and differential.
DR Genevisible; Q86V59; HS.
DR InterPro; IPR026523; PNMA.
DR PANTHER; PTHR23095; PTHR23095; 1.
DR Pfam; PF14893; PNMA; 1.
PE 1: Evidence at protein level;
KW Alternative splicing; Reference proteome.
FT CHAIN 1..439
FT /note="Paraneoplastic antigen-like protein 8A"
FT /id="PRO_0000325836"
FT REGION 208..439
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 235..249
FT /note="Basic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 292..306
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 378..403
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 424..439
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT VAR_SEQ 367..378
FT /note="VSLGPVSYVLVD -> NPERFDLGDHPY (in isoform 2)"
FT /evidence="ECO:0000303|PubMed:17974005"
FT /id="VSP_032441"
FT VAR_SEQ 379..439
FT /note="Missing (in isoform 2)"
FT /evidence="ECO:0000303|PubMed:17974005"
FT /id="VSP_032442"
FT VARIANT 80
FT /note="S -> T (in dbSNP:rs12610254)"
FT /id="VAR_039935"
FT VARIANT 97
FT /note="C -> Y (in dbSNP:rs7248888)"
FT /id="VAR_039936"
FT CONFLICT 319
FT /note="P -> S (in Ref. 3; AAH32508)"
FT /evidence="ECO:0000305"
SQ SEQUENCE 439 AA; 48161 MW; 43E43FA1CAEC1E81 CRC64;
MSKTMAMNLL EDWCRGMEVD IHRSLLVTGI PEDCGQAEIE ETLNGVLSPL GPYRVLNKIF
VREENVKAAL IEVGEGVNLS TIPREFPGRG GVWRVVCRDP TQDAEFLKNL NEFLDAEGRT
WEDVVRLLQL NHPTLSQNQH QPPENWAEAL GVLLGAVVQI IFCMDAEIRS REEARAQEAA
EFEEMAAWAL AAGRKVKKEP GLAAEVGSAL KAETPNNWNA TEDQHEPTKP LVRRAGAKSR
SRRKKQKKNS RQEAVPWKKP KGINSNSTAN LEDPEVGDAE SMAISEPIKG SRKPCVNKEE
LALKKPMAKC AWKGPREPPQ DARAEAESPG GASESDQDGG HESPPKKKAV AWVSAKNPAP
MRKKKKVSLG PVSYVLVDSE DGRKKPVMPK KGPGSRREAS DQKAPRGQQP AEATASTSRG
PKAKPEGSPR RATNESRKV
