PNM8B_HUMAN
ID PNM8B_HUMAN Reviewed; 635 AA.
AC Q9ULN7; C9JGD5; M0R374; Q08E79; Q0D2F9; Q6ZVD1;
DT 18-MAR-2008, integrated into UniProtKB/Swiss-Prot.
DT 28-MAR-2018, sequence version 4.
DT 03-AUG-2022, entry version 129.
DE RecName: Full=Paraneoplastic antigen-like protein 8B;
DE AltName: Full=PNMA-like protein 2;
GN Name=PNMA8B {ECO:0000312|HGNC:HGNC:29206}; Synonyms=KIAA1183, PNMAL2;
OS Homo sapiens (Human).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae;
OC Homo.
OX NCBI_TaxID=9606;
RN [1]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 1).
RC TISSUE=Brain;
RX PubMed=14702039; DOI=10.1038/ng1285;
RA Ota T., Suzuki Y., Nishikawa T., Otsuki T., Sugiyama T., Irie R.,
RA Wakamatsu A., Hayashi K., Sato H., Nagai K., Kimura K., Makita H.,
RA Sekine M., Obayashi M., Nishi T., Shibahara T., Tanaka T., Ishii S.,
RA Yamamoto J., Saito K., Kawai Y., Isono Y., Nakamura Y., Nagahari K.,
RA Murakami K., Yasuda T., Iwayanagi T., Wagatsuma M., Shiratori A., Sudo H.,
RA Hosoiri T., Kaku Y., Kodaira H., Kondo H., Sugawara M., Takahashi M.,
RA Kanda K., Yokoi T., Furuya T., Kikkawa E., Omura Y., Abe K., Kamihara K.,
RA Katsuta N., Sato K., Tanikawa M., Yamazaki M., Ninomiya K., Ishibashi T.,
RA Yamashita H., Murakawa K., Fujimori K., Tanai H., Kimata M., Watanabe M.,
RA Hiraoka S., Chiba Y., Ishida S., Ono Y., Takiguchi S., Watanabe S.,
RA Yosida M., Hotuta T., Kusano J., Kanehori K., Takahashi-Fujii A., Hara H.,
RA Tanase T.-O., Nomura Y., Togiya S., Komai F., Hara R., Takeuchi K.,
RA Arita M., Imose N., Musashino K., Yuuki H., Oshima A., Sasaki N.,
RA Aotsuka S., Yoshikawa Y., Matsunawa H., Ichihara T., Shiohata N., Sano S.,
RA Moriya S., Momiyama H., Satoh N., Takami S., Terashima Y., Suzuki O.,
RA Nakagawa S., Senoh A., Mizoguchi H., Goto Y., Shimizu F., Wakebe H.,
RA Hishigaki H., Watanabe T., Sugiyama A., Takemoto M., Kawakami B.,
RA Yamazaki M., Watanabe K., Kumagai A., Itakura S., Fukuzumi Y., Fujimori Y.,
RA Komiyama M., Tashiro H., Tanigami A., Fujiwara T., Ono T., Yamada K.,
RA Fujii Y., Ozaki K., Hirao M., Ohmori Y., Kawabata A., Hikiji T.,
RA Kobatake N., Inagaki H., Ikema Y., Okamoto S., Okitani R., Kawakami T.,
RA Noguchi S., Itoh T., Shigeta K., Senba T., Matsumura K., Nakajima Y.,
RA Mizuno T., Morinaga M., Sasaki M., Togashi T., Oyama M., Hata H.,
RA Watanabe M., Komatsu T., Mizushima-Sugano J., Satoh T., Shirai Y.,
RA Takahashi Y., Nakagawa K., Okumura K., Nagase T., Nomura N., Kikuchi H.,
RA Masuho Y., Yamashita R., Nakai K., Yada T., Nakamura Y., Ohara O.,
RA Isogai T., Sugano S.;
RT "Complete sequencing and characterization of 21,243 full-length human
RT cDNAs.";
RL Nat. Genet. 36:40-45(2004).
RN [2]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RX PubMed=15057824; DOI=10.1038/nature02399;
RA Grimwood J., Gordon L.A., Olsen A.S., Terry A., Schmutz J., Lamerdin J.E.,
RA Hellsten U., Goodstein D., Couronne O., Tran-Gyamfi M., Aerts A.,
RA Altherr M., Ashworth L., Bajorek E., Black S., Branscomb E., Caenepeel S.,
RA Carrano A.V., Caoile C., Chan Y.M., Christensen M., Cleland C.A.,
RA Copeland A., Dalin E., Dehal P., Denys M., Detter J.C., Escobar J.,
RA Flowers D., Fotopulos D., Garcia C., Georgescu A.M., Glavina T., Gomez M.,
RA Gonzales E., Groza M., Hammon N., Hawkins T., Haydu L., Ho I., Huang W.,
RA Israni S., Jett J., Kadner K., Kimball H., Kobayashi A., Larionov V.,
RA Leem S.-H., Lopez F., Lou Y., Lowry S., Malfatti S., Martinez D.,
RA McCready P.M., Medina C., Morgan J., Nelson K., Nolan M., Ovcharenko I.,
RA Pitluck S., Pollard M., Popkie A.P., Predki P., Quan G., Ramirez L.,
RA Rash S., Retterer J., Rodriguez A., Rogers S., Salamov A., Salazar A.,
RA She X., Smith D., Slezak T., Solovyev V., Thayer N., Tice H., Tsai M.,
RA Ustaszewska A., Vo N., Wagner M., Wheeler J., Wu K., Xie G., Yang J.,
RA Dubchak I., Furey T.S., DeJong P., Dickson M., Gordon D., Eichler E.E.,
RA Pennacchio L.A., Richardson P., Stubbs L., Rokhsar D.S., Myers R.M.,
RA Rubin E.M., Lucas S.M.;
RT "The DNA sequence and biology of human chromosome 19.";
RL Nature 428:529-535(2004).
RN [3]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] OF 293-635 (ISOFORM 2).
RC TISSUE=Brain;
RX PubMed=10574461; DOI=10.1093/dnares/6.5.329;
RA Hirosawa M., Nagase T., Ishikawa K., Kikuno R., Nomura N., Ohara O.;
RT "Characterization of cDNA clones selected by the GeneMark analysis from
RT size-fractionated cDNA libraries from human brain.";
RL DNA Res. 6:329-336(1999).
CC -!- ALTERNATIVE PRODUCTS:
CC Event=Alternative splicing; Named isoforms=2;
CC Name=2;
CC IsoId=Q9ULN7-5; Sequence=Displayed;
CC Name=1;
CC IsoId=Q9ULN7-1; Sequence=VSP_059423, VSP_059424;
CC -!- SIMILARITY: Belongs to the PNMA family. {ECO:0000305}.
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DR EMBL; AK124720; BAC85931.1; -; mRNA.
DR EMBL; AC011484; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR EMBL; AB033009; BAA86497.1; -; mRNA.
DR CCDS; CCDS59400.1; -. [Q9ULN7-5]
DR RefSeq; NP_065760.1; NM_020709.2. [Q9ULN7-5]
DR AlphaFoldDB; Q9ULN7; -.
DR BioGRID; 121539; 1.
DR STRING; 9606.ENSP00000473036; -.
DR iPTMnet; Q9ULN7; -.
DR PhosphoSitePlus; Q9ULN7; -.
DR BioMuta; PNMA8B; -.
DR DMDM; 408360249; -.
DR EPD; Q9ULN7; -.
DR MassIVE; Q9ULN7; -.
DR PaxDb; Q9ULN7; -.
DR PeptideAtlas; Q9ULN7; -.
DR PRIDE; Q9ULN7; -.
DR ProteomicsDB; 10092; -.
DR ProteomicsDB; 85080; -. [Q9ULN7-1]
DR Antibodypedia; 49341; 6 antibodies from 6 providers.
DR DNASU; 57469; -.
DR Ensembl; ENST00000599531.2; ENSP00000473036.1; ENSG00000204851.7. [Q9ULN7-5]
DR GeneID; 57469; -.
DR KEGG; hsa:57469; -.
DR MANE-Select; ENST00000599531.2; ENSP00000473036.1; NM_020709.3; NP_065760.1.
DR UCSC; uc002pes.3; human. [Q9ULN7-5]
DR CTD; 57469; -.
DR GeneCards; PNMA8B; -.
DR HGNC; HGNC:29206; PNMA8B.
DR HPA; ENSG00000204851; Tissue enhanced (adrenal gland, brain).
DR neXtProt; NX_Q9ULN7; -.
DR OpenTargets; ENSG00000204851; -.
DR PharmGKB; PA162399847; -.
DR VEuPathDB; HostDB:ENSG00000204851; -.
DR eggNOG; KOG0657; Eukaryota.
DR GeneTree; ENSGT01030000234522; -.
DR HOGENOM; CLU_036264_1_0_1; -.
DR InParanoid; Q9ULN7; -.
DR OMA; NAWEGGK; -.
DR OrthoDB; 687996at2759; -.
DR PhylomeDB; Q9ULN7; -.
DR TreeFam; TF335054; -.
DR PathwayCommons; Q9ULN7; -.
DR BioGRID-ORCS; 57469; 9 hits in 1055 CRISPR screens.
DR GenomeRNAi; 57469; -.
DR Pharos; Q9ULN7; Tdark.
DR PRO; PR:Q9ULN7; -.
DR Proteomes; UP000005640; Chromosome 19.
DR RNAct; Q9ULN7; protein.
DR Bgee; ENSG00000204851; Expressed in prefrontal cortex and 112 other tissues.
DR Genevisible; Q9ULN7; HS.
DR InterPro; IPR026523; PNMA.
DR PANTHER; PTHR23095; PTHR23095; 1.
DR Pfam; PF14893; PNMA; 1.
PE 2: Evidence at transcript level;
KW Alternative splicing; Reference proteome.
FT CHAIN 1..635
FT /note="Paraneoplastic antigen-like protein 8B"
FT /id="PRO_0000325839"
FT REGION 115..202
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 260..332
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 492..635
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 129..145
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 157..185
FT /note="Basic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 260..286
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 306..328
FT /note="Acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 505..523
FT /note="Acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 619..635
FT /note="Basic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT VAR_SEQ 246..279
FT /note="EEDGPREFLALVTVTDKSKKEEAEKEPAGAESIR -> GPCPTCPWEGIGGF
FT GCDLTVQTRLSQSYVRDTQM (in isoform 1)"
FT /evidence="ECO:0000303|PubMed:14702039"
FT /id="VSP_059423"
FT VAR_SEQ 280..635
FT /note="Missing (in isoform 1)"
FT /evidence="ECO:0000303|PubMed:14702039"
FT /id="VSP_059424"
FT CONFLICT 249..250
FT /note="GP -> A (in Ref. 1; BAC85931)"
FT /evidence="ECO:0000305"
FT CONFLICT 563
FT /note="G -> GGR (in Ref. 3; BAA86497)"
FT /evidence="ECO:0000305"
FT CONFLICT 599
FT /note="A -> S (in Ref. 3; BAA86497)"
FT /evidence="ECO:0000305"
SQ SEQUENCE 635 AA; 68615 MW; E76AEDEB43840528 CRC64;
MAMSLLQDWC RSLDVDAHRA LLVTGIPEGL EQADVEAVLQ PTLLPLGTFR LRHMKALMNE
KAQAALVEFV EDVNHAAIPR EIPGKDGVWR VLWKDRAQDT RVLRQMRRLL LDDGPTQAAE
AGTPGEAPTP PASETQAQDS GEVTGQAGSL LGAARNPRRG RRGRRNRTRR NRLTQKGKKR
SRGGRPSAPA RSEAEDSSDE SLGIVIEEID QGDLSGEEDQ SALYATLQAA ARELVRQWAP
CNSEGEEDGP REFLALVTVT DKSKKEEAEK EPAGAESIRL NTKEDKNGVP DLVALLAVRD
TPDEEPVDSD TSESDSQESG DQETEELDNP EFVAIVAYTD PSDPWAREEM LKIASVIESL
GWSDEKDKRD PLRQVLSVMS KDTNGTRVKV EEAGREVDAV VLRKAGDDGD LRECISTLAQ
PDLPPQAKKA GRGLFGGWSE HREDEGGLLE LVALLAAQDM AEVMKEEKEN AWEGGKYKYP
KGKLGEVLAL LAARENMGSN EGSEEASDEQ SEEESEDTES EASEPEDRAS RKPRAKRART
APRGLTPAGA PPTASGARKT RAGGRGRGRG VTPEKKAGSR GSAQDDAAGS RKKKGSAGAG
AHARAGEAKG QAPTGSKAAR GKKARRGRRL PPKCR
