PNMA1_HUMAN
ID PNMA1_HUMAN Reviewed; 353 AA.
AC Q8ND90; A8K4L5; O95144; Q8NG07;
DT 24-OCT-2003, integrated into UniProtKB/Swiss-Prot.
DT 24-OCT-2003, sequence version 2.
DT 03-AUG-2022, entry version 150.
DE RecName: Full=Paraneoplastic antigen Ma1;
DE AltName: Full=37 kDa neuronal protein;
DE AltName: Full=Neuron- and testis-specific protein 1;
GN Name=PNMA1; Synonyms=MA1;
OS Homo sapiens (Human).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae;
OC Homo.
OX NCBI_TaxID=9606;
RN [1]
RP NUCLEOTIDE SEQUENCE [MRNA], SUBCELLULAR LOCATION, AND TISSUE SPECIFICITY.
RC TISSUE=Cerebellum;
RX PubMed=10050892; DOI=10.1093/brain/122.1.27;
RA Dalmau J., Gultekin S.H., Voltz R., Hoard R., DesChamps T., Balmaceda C.,
RA Batchelor T., Gerstner E., Eichen J., Frennier J., Posner J.B.,
RA Rosenfeld M.R.;
RT "Ma1, a novel neuron- and testis-specific protein, is recognized by the
RT serum of patients with paraneoplastic neurological disorders.";
RL Brain 122:27-39(1999).
RN [2]
RP NUCLEOTIDE SEQUENCE [MRNA].
RX PubMed=16214224; DOI=10.1016/j.jneuroim.2005.08.019;
RA Schueller M., Jenne D.E., Voltz R.;
RT "The human PNMA family: novel neuronal proteins implicated in
RT paraneoplastic neurological disease.";
RL J. Neuroimmunol. 169:172-176(2005).
RN [3]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
RX PubMed=14702039; DOI=10.1038/ng1285;
RA Ota T., Suzuki Y., Nishikawa T., Otsuki T., Sugiyama T., Irie R.,
RA Wakamatsu A., Hayashi K., Sato H., Nagai K., Kimura K., Makita H.,
RA Sekine M., Obayashi M., Nishi T., Shibahara T., Tanaka T., Ishii S.,
RA Yamamoto J., Saito K., Kawai Y., Isono Y., Nakamura Y., Nagahari K.,
RA Murakami K., Yasuda T., Iwayanagi T., Wagatsuma M., Shiratori A., Sudo H.,
RA Hosoiri T., Kaku Y., Kodaira H., Kondo H., Sugawara M., Takahashi M.,
RA Kanda K., Yokoi T., Furuya T., Kikkawa E., Omura Y., Abe K., Kamihara K.,
RA Katsuta N., Sato K., Tanikawa M., Yamazaki M., Ninomiya K., Ishibashi T.,
RA Yamashita H., Murakawa K., Fujimori K., Tanai H., Kimata M., Watanabe M.,
RA Hiraoka S., Chiba Y., Ishida S., Ono Y., Takiguchi S., Watanabe S.,
RA Yosida M., Hotuta T., Kusano J., Kanehori K., Takahashi-Fujii A., Hara H.,
RA Tanase T.-O., Nomura Y., Togiya S., Komai F., Hara R., Takeuchi K.,
RA Arita M., Imose N., Musashino K., Yuuki H., Oshima A., Sasaki N.,
RA Aotsuka S., Yoshikawa Y., Matsunawa H., Ichihara T., Shiohata N., Sano S.,
RA Moriya S., Momiyama H., Satoh N., Takami S., Terashima Y., Suzuki O.,
RA Nakagawa S., Senoh A., Mizoguchi H., Goto Y., Shimizu F., Wakebe H.,
RA Hishigaki H., Watanabe T., Sugiyama A., Takemoto M., Kawakami B.,
RA Yamazaki M., Watanabe K., Kumagai A., Itakura S., Fukuzumi Y., Fujimori Y.,
RA Komiyama M., Tashiro H., Tanigami A., Fujiwara T., Ono T., Yamada K.,
RA Fujii Y., Ozaki K., Hirao M., Ohmori Y., Kawabata A., Hikiji T.,
RA Kobatake N., Inagaki H., Ikema Y., Okamoto S., Okitani R., Kawakami T.,
RA Noguchi S., Itoh T., Shigeta K., Senba T., Matsumura K., Nakajima Y.,
RA Mizuno T., Morinaga M., Sasaki M., Togashi T., Oyama M., Hata H.,
RA Watanabe M., Komatsu T., Mizushima-Sugano J., Satoh T., Shirai Y.,
RA Takahashi Y., Nakagawa K., Okumura K., Nagase T., Nomura N., Kikuchi H.,
RA Masuho Y., Yamashita R., Nakai K., Yada T., Nakamura Y., Ohara O.,
RA Isogai T., Sugano S.;
RT "Complete sequencing and characterization of 21,243 full-length human
RT cDNAs.";
RL Nat. Genet. 36:40-45(2004).
RN [4]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RA Mural R.J., Istrail S., Sutton G.G., Florea L., Halpern A.L., Mobarry C.M.,
RA Lippert R., Walenz B., Shatkay H., Dew I., Miller J.R., Flanigan M.J.,
RA Edwards N.J., Bolanos R., Fasulo D., Halldorsson B.V., Hannenhalli S.,
RA Turner R., Yooseph S., Lu F., Nusskern D.R., Shue B.C., Zheng X.H.,
RA Zhong F., Delcher A.L., Huson D.H., Kravitz S.A., Mouchard L., Reinert K.,
RA Remington K.A., Clark A.G., Waterman M.S., Eichler E.E., Adams M.D.,
RA Hunkapiller M.W., Myers E.W., Venter J.C.;
RL Submitted (JUL-2005) to the EMBL/GenBank/DDBJ databases.
RN [5]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
RC TISSUE=Prostate;
RX PubMed=15489334; DOI=10.1101/gr.2596504;
RG The MGC Project Team;
RT "The status, quality, and expansion of the NIH full-length cDNA project:
RT the Mammalian Gene Collection (MGC).";
RL Genome Res. 14:2121-2127(2004).
RN [6]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] OF 162-353.
RC TISSUE=Testis;
RX PubMed=17974005; DOI=10.1186/1471-2164-8-399;
RA Bechtel S., Rosenfelder H., Duda A., Schmidt C.P., Ernst U.,
RA Wellenreuther R., Mehrle A., Schuster C., Bahr A., Bloecker H., Heubner D.,
RA Hoerlein A., Michel G., Wedler H., Koehrer K., Ottenwaelder B., Poustka A.,
RA Wiemann S., Schupp I.;
RT "The full-ORF clone resource of the German cDNA consortium.";
RL BMC Genomics 8:399-399(2007).
RN [7]
RP TISSUE SPECIFICITY.
RX PubMed=19366867; DOI=10.1093/cercor/bhp062;
RA Takaji M., Komatsu Y., Watakabe A., Hashikawa T., Yamamori T.;
RT "Paraneoplastic antigen-like 5 gene (PNMA5) is preferentially expressed in
RT the association areas in a primate specific manner.";
RL Cereb. Cortex 19:2865-2879(2009).
CC -!- INTERACTION:
CC Q8ND90; Q96IX9: ANKRD36BP1; NbExp=3; IntAct=EBI-302345, EBI-744859;
CC Q8ND90; Q7Z2E3: APTX; NbExp=3; IntAct=EBI-302345, EBI-847814;
CC Q8ND90; Q7Z2E3-7: APTX; NbExp=3; IntAct=EBI-302345, EBI-12298187;
CC Q8ND90; Q15052: ARHGEF6; NbExp=3; IntAct=EBI-302345, EBI-1642523;
CC Q8ND90; Q03989: ARID5A; NbExp=5; IntAct=EBI-302345, EBI-948603;
CC Q8ND90; O95671: ASMTL; NbExp=3; IntAct=EBI-302345, EBI-743231;
CC Q8ND90; P48047: ATP5PO; NbExp=4; IntAct=EBI-302345, EBI-355815;
CC Q8ND90; O75348: ATP6V1G1; NbExp=3; IntAct=EBI-302345, EBI-711802;
CC Q8ND90; Q9BXY8: BEX2; NbExp=3; IntAct=EBI-302345, EBI-745073;
CC Q8ND90; Q13895: BYSL; NbExp=3; IntAct=EBI-302345, EBI-358049;
CC Q8ND90; Q9NX04: C1orf109; NbExp=3; IntAct=EBI-302345, EBI-8643161;
CC Q8ND90; Q0VAL7: C21orf58; NbExp=3; IntAct=EBI-302345, EBI-10226774;
CC Q8ND90; Q9H7E9: C8orf33; NbExp=3; IntAct=EBI-302345, EBI-715389;
CC Q8ND90; Q9Y2V2: CARHSP1; NbExp=3; IntAct=EBI-302345, EBI-718719;
CC Q8ND90; Q9HC52: CBX8; NbExp=3; IntAct=EBI-302345, EBI-712912;
CC Q8ND90; Q8IYE0-2: CCDC146; NbExp=3; IntAct=EBI-302345, EBI-10247802;
CC Q8ND90; E9PSE9: CCDC198; NbExp=3; IntAct=EBI-302345, EBI-11748295;
CC Q8ND90; Q9NVL8: CCDC198; NbExp=3; IntAct=EBI-302345, EBI-10238351;
CC Q8ND90; P51959: CCNG1; NbExp=3; IntAct=EBI-302345, EBI-3905829;
CC Q8ND90; Q07002: CDK18; NbExp=3; IntAct=EBI-302345, EBI-746238;
CC Q8ND90; Q96M91: CFAP53; NbExp=3; IntAct=EBI-302345, EBI-742422;
CC Q8ND90; Q9UKJ5: CHIC2; NbExp=3; IntAct=EBI-302345, EBI-741528;
CC Q8ND90; Q8NE01: CNNM3; NbExp=3; IntAct=EBI-302345, EBI-741032;
CC Q8ND90; Q8NE01-3: CNNM3; NbExp=3; IntAct=EBI-302345, EBI-10269984;
CC Q8ND90; P10606: COX5B; NbExp=3; IntAct=EBI-302345, EBI-1053725;
CC Q8ND90; Q9GZU7: CTDSP1; NbExp=2; IntAct=EBI-302345, EBI-751587;
CC Q8ND90; Q9UI47-2: CTNNA3; NbExp=3; IntAct=EBI-302345, EBI-11962928;
CC Q8ND90; Q9UER7: DAXX; NbExp=5; IntAct=EBI-302345, EBI-77321;
CC Q8ND90; Q9UJW0: DCTN4; NbExp=3; IntAct=EBI-302345, EBI-2134033;
CC Q8ND90; Q08426: EHHADH; NbExp=3; IntAct=EBI-302345, EBI-2339219;
CC Q8ND90; Q9H0I2: ENKD1; NbExp=4; IntAct=EBI-302345, EBI-744099;
CC Q8ND90; O95990-3: FAM107A; NbExp=3; IntAct=EBI-302345, EBI-10192902;
CC Q8ND90; Q9BQ89: FAM110A; NbExp=3; IntAct=EBI-302345, EBI-1752811;
CC Q8ND90; Q3B820: FAM161A; NbExp=3; IntAct=EBI-302345, EBI-719941;
CC Q8ND90; Q96MY7: FAM161B; NbExp=3; IntAct=EBI-302345, EBI-7225287;
CC Q8ND90; Q8TES7-6: FBF1; NbExp=3; IntAct=EBI-302345, EBI-10244131;
CC Q8ND90; Q96D16: FBXL18; NbExp=5; IntAct=EBI-302345, EBI-744419;
CC Q8ND90; Q96JP0: FEM1C; NbExp=3; IntAct=EBI-302345, EBI-2515330;
CC Q8ND90; Q9NU39: FOXD4L1; NbExp=3; IntAct=EBI-302345, EBI-11320806;
CC Q8ND90; Q6VB84: FOXD4L3; NbExp=3; IntAct=EBI-302345, EBI-11961494;
CC Q8ND90; Q8TAE8: GADD45GIP1; NbExp=3; IntAct=EBI-302345, EBI-372506;
CC Q8ND90; P55040: GEM; NbExp=3; IntAct=EBI-302345, EBI-744104;
CC Q8ND90; O95872: GPANK1; NbExp=4; IntAct=EBI-302345, EBI-751540;
CC Q8ND90; O00155: GPR25; NbExp=3; IntAct=EBI-302345, EBI-10178951;
CC Q8ND90; A4D1E9: GTPBP10; NbExp=4; IntAct=EBI-302345, EBI-5453796;
CC Q8ND90; Q9GZV7: HAPLN2; NbExp=3; IntAct=EBI-302345, EBI-11956675;
CC Q8ND90; A0A024R8L2: hCG_1987119; NbExp=3; IntAct=EBI-302345, EBI-14103818;
CC Q8ND90; P08631-2: HCK; NbExp=3; IntAct=EBI-302345, EBI-9834454;
CC Q8ND90; P56524: HDAC4; NbExp=3; IntAct=EBI-302345, EBI-308629;
CC Q8ND90; A0A0S2Z4Q4: HGS; NbExp=3; IntAct=EBI-302345, EBI-16429135;
CC Q8ND90; P17482: HOXB9; NbExp=6; IntAct=EBI-302345, EBI-745290;
CC Q8ND90; Q86VF2-5: IGFN1; NbExp=3; IntAct=EBI-302345, EBI-11955401;
CC Q8ND90; Q9C086: INO80B; NbExp=3; IntAct=EBI-302345, EBI-715611;
CC Q8ND90; Q7Z3B3: KANSL1; NbExp=3; IntAct=EBI-302345, EBI-740244;
CC Q8ND90; Q14657: LAGE3; NbExp=3; IntAct=EBI-302345, EBI-1052105;
CC Q8ND90; Q96GY3: LIN37; NbExp=3; IntAct=EBI-302345, EBI-748884;
CC Q8ND90; Q8TAP4-4: LMO3; NbExp=5; IntAct=EBI-302345, EBI-11742507;
CC Q8ND90; Q8TBB1: LNX1; NbExp=7; IntAct=EBI-302345, EBI-739832;
CC Q8ND90; Q9Y586: MAB21L2; NbExp=3; IntAct=EBI-302345, EBI-6659161;
CC Q8ND90; Q96GV9: MACIR; NbExp=3; IntAct=EBI-302345, EBI-2350695;
CC Q8ND90; Q96L34: MARK4; NbExp=2; IntAct=EBI-302345, EBI-302319;
CC Q8ND90; P33993: MCM7; NbExp=3; IntAct=EBI-302345, EBI-355924;
CC Q8ND90; Q96G25-2: MED8; NbExp=3; IntAct=EBI-302345, EBI-10286267;
CC Q8ND90; Q9H7H0: METTL17; NbExp=7; IntAct=EBI-302345, EBI-749353;
CC Q8ND90; Q9H7H0-2: METTL17; NbExp=6; IntAct=EBI-302345, EBI-11098807;
CC Q8ND90; Q8IVT4: MGC50722; NbExp=3; IntAct=EBI-302345, EBI-14086479;
CC Q8ND90; Q7Z7H8: MRPL10; NbExp=3; IntAct=EBI-302345, EBI-723524;
CC Q8ND90; Q9Y3B7: MRPL11; NbExp=6; IntAct=EBI-302345, EBI-5453723;
CC Q8ND90; Q16540: MRPL23; NbExp=3; IntAct=EBI-302345, EBI-1046141;
CC Q8ND90; Q9NP98: MYOZ1; NbExp=3; IntAct=EBI-302345, EBI-744402;
CC Q8ND90; P48146: NPBWR2; NbExp=3; IntAct=EBI-302345, EBI-10210114;
CC Q8ND90; Q6X4W1-2: NSMF; NbExp=3; IntAct=EBI-302345, EBI-12028784;
CC Q8ND90; Q96HA8: NTAQ1; NbExp=6; IntAct=EBI-302345, EBI-741158;
CC Q8ND90; Q9BRJ7: NUDT16L1; NbExp=3; IntAct=EBI-302345, EBI-2949792;
CC Q8ND90; Q8TEW0: PARD3; NbExp=4; IntAct=EBI-302345, EBI-81968;
CC Q8ND90; Q9NPB6: PARD6A; NbExp=2; IntAct=EBI-302345, EBI-81876;
CC Q8ND90; Q9BYG5: PARD6B; NbExp=2; IntAct=EBI-302345, EBI-295391;
CC Q8ND90; C3PTT6: PAUF; NbExp=3; IntAct=EBI-302345, EBI-3505892;
CC Q8ND90; J3QSH9: PER1; NbExp=3; IntAct=EBI-302345, EBI-10178671;
CC Q8ND90; Q13526: PIN1; NbExp=3; IntAct=EBI-302345, EBI-714158;
CC Q8ND90; Q9Y237: PIN4; NbExp=3; IntAct=EBI-302345, EBI-714599;
CC Q8ND90; Q16512: PKN1; NbExp=3; IntAct=EBI-302345, EBI-602382;
CC Q8ND90; Q6P5Z2: PKN3; NbExp=3; IntAct=EBI-302345, EBI-1384335;
CC Q8ND90; Q96PV4: PNMA5; NbExp=6; IntAct=EBI-302345, EBI-10171633;
CC Q8ND90; P0CW24: PNMA6A; NbExp=7; IntAct=EBI-302345, EBI-721270;
CC Q8ND90; Q8WUT1: POLDIP3; NbExp=3; IntAct=EBI-302345, EBI-10276663;
CC Q8ND90; Q9UGP5-2: POLL; NbExp=3; IntAct=EBI-302345, EBI-10320765;
CC Q8ND90; Q6PIY2: POLM; NbExp=3; IntAct=EBI-302345, EBI-10253863;
CC Q8ND90; P41743: PRKCI; NbExp=2; IntAct=EBI-302345, EBI-286199;
CC Q8ND90; Q99633: PRPF18; NbExp=3; IntAct=EBI-302345, EBI-2798416;
CC Q8ND90; Q8WWY3: PRPF31; NbExp=11; IntAct=EBI-302345, EBI-1567797;
CC Q8ND90; P25786: PSMA1; NbExp=6; IntAct=EBI-302345, EBI-359352;
CC Q8ND90; O75771: RAD51D; NbExp=3; IntAct=EBI-302345, EBI-1055693;
CC Q8ND90; Q96IZ5: RBM41; NbExp=3; IntAct=EBI-302345, EBI-740773;
CC Q8ND90; Q9BUL9: RPP25; NbExp=3; IntAct=EBI-302345, EBI-366570;
CC Q8ND90; Q8N5L8: RPP25L; NbExp=3; IntAct=EBI-302345, EBI-10189722;
CC Q8ND90; Q9H1X1: RSPH9; NbExp=3; IntAct=EBI-302345, EBI-10305303;
CC Q8ND90; Q7L4I2-2: RSRC2; NbExp=3; IntAct=EBI-302345, EBI-10256202;
CC Q8ND90; Q14D33: RTP5; NbExp=6; IntAct=EBI-302345, EBI-10217913;
CC Q8ND90; Q9BVN2: RUSC1; NbExp=8; IntAct=EBI-302345, EBI-6257312;
CC Q8ND90; P57086: SCAND1; NbExp=3; IntAct=EBI-302345, EBI-745846;
CC Q8ND90; Q9BWG6: SCNM1; NbExp=8; IntAct=EBI-302345, EBI-748391;
CC Q8ND90; O00560: SDCBP; NbExp=8; IntAct=EBI-302345, EBI-727004;
CC Q8ND90; Q9C0C4: SEMA4C; NbExp=6; IntAct=EBI-302345, EBI-10303490;
CC Q8ND90; Q9H788: SH2D4A; NbExp=6; IntAct=EBI-302345, EBI-747035;
CC Q8ND90; Q92529: SHC3; NbExp=3; IntAct=EBI-302345, EBI-79084;
CC Q8ND90; A0PJX4: SHISA3; NbExp=3; IntAct=EBI-302345, EBI-10171518;
CC Q8ND90; Q6ZT89: SLC25A48; NbExp=3; IntAct=EBI-302345, EBI-10255185;
CC Q8ND90; Q9GZT3: SLIRP; NbExp=3; IntAct=EBI-302345, EBI-1050793;
CC Q8ND90; Q9BZL3: SMIM3; NbExp=3; IntAct=EBI-302345, EBI-741850;
CC Q8ND90; P14678-2: SNRPB; NbExp=6; IntAct=EBI-302345, EBI-372475;
CC Q8ND90; P08579: SNRPB2; NbExp=5; IntAct=EBI-302345, EBI-1053651;
CC Q8ND90; Q9H0A9: SPATC1L; NbExp=3; IntAct=EBI-302345, EBI-372911;
CC Q8ND90; Q9H0A9-2: SPATC1L; NbExp=3; IntAct=EBI-302345, EBI-11995806;
CC Q8ND90; Q9UQ90: SPG7; NbExp=7; IntAct=EBI-302345, EBI-717201;
CC Q8ND90; Q96FJ0: STAMBPL1; NbExp=3; IntAct=EBI-302345, EBI-745021;
CC Q8ND90; Q9H5I1: SUV39H2; NbExp=5; IntAct=EBI-302345, EBI-723127;
CC Q8ND90; Q5VWN6: TASOR2; NbExp=3; IntAct=EBI-302345, EBI-745958;
CC Q8ND90; Q15560: TCEA2; NbExp=3; IntAct=EBI-302345, EBI-710310;
CC Q8ND90; Q8N8B7: TCEANC; NbExp=3; IntAct=EBI-302345, EBI-954696;
CC Q8ND90; Q8N8B7-2: TCEANC; NbExp=3; IntAct=EBI-302345, EBI-11955057;
CC Q8ND90; O95988: TCL1B; NbExp=3; IntAct=EBI-302345, EBI-727338;
CC Q8ND90; A0A0S2Z4F2: TEAD4; NbExp=3; IntAct=EBI-302345, EBI-16429215;
CC Q8ND90; D3DUQ6: TEAD4; NbExp=3; IntAct=EBI-302345, EBI-10176734;
CC Q8ND90; Q15561: TEAD4; NbExp=3; IntAct=EBI-302345, EBI-747736;
CC Q8ND90; Q0P5Q0: TMSB4X; NbExp=3; IntAct=EBI-302345, EBI-10226570;
CC Q8ND90; P19237: TNNI1; NbExp=6; IntAct=EBI-302345, EBI-746692;
CC Q8ND90; Q8IWZ5: TRIM42; NbExp=3; IntAct=EBI-302345, EBI-5235829;
CC Q8ND90; Q86UV6-2: TRIM74; NbExp=3; IntAct=EBI-302345, EBI-10259086;
CC Q8ND90; Q9Y260: TRPV6; NbExp=3; IntAct=EBI-302345, EBI-750052;
CC Q8ND90; Q9NRE2: TSHZ2; NbExp=3; IntAct=EBI-302345, EBI-10687282;
CC Q8ND90; Q9UJ04: TSPYL4; NbExp=3; IntAct=EBI-302345, EBI-308511;
CC Q8ND90; Q5W5X9-3: TTC23; NbExp=3; IntAct=EBI-302345, EBI-9090990;
CC Q8ND90; Q8N5M4: TTC9C; NbExp=3; IntAct=EBI-302345, EBI-2851213;
CC Q8ND90; O14530: TXNDC9; NbExp=3; IntAct=EBI-302345, EBI-707554;
CC Q8ND90; Q9UMX0: UBQLN1; NbExp=4; IntAct=EBI-302345, EBI-741480;
CC Q8ND90; Q9UMX0-2: UBQLN1; NbExp=3; IntAct=EBI-302345, EBI-10173939;
CC Q8ND90; Q96HZ7: URB1-AS1; NbExp=3; IntAct=EBI-302345, EBI-10288943;
CC Q8ND90; O75604: USP2; NbExp=3; IntAct=EBI-302345, EBI-743272;
CC Q8ND90; P61758: VBP1; NbExp=3; IntAct=EBI-302345, EBI-357430;
CC Q8ND90; Q9Y2B5: VPS9D1; NbExp=3; IntAct=EBI-302345, EBI-9031083;
CC Q8ND90; Q64LD2: WDR25; NbExp=3; IntAct=EBI-302345, EBI-744560;
CC Q8ND90; Q06250: WT1-AS; NbExp=3; IntAct=EBI-302345, EBI-10223946;
CC Q8ND90; Q53FD0: ZC2HC1C; NbExp=4; IntAct=EBI-302345, EBI-740767;
CC Q8ND90; Q6PEW1: ZCCHC12; NbExp=10; IntAct=EBI-302345, EBI-748373;
CC Q8ND90; Q68DK2-5: ZFYVE26; NbExp=3; IntAct=EBI-302345, EBI-8656416;
CC Q8ND90; Q9UQR1-2: ZNF148; NbExp=3; IntAct=EBI-302345, EBI-11742222;
CC Q8ND90; P13682: ZNF35; NbExp=3; IntAct=EBI-302345, EBI-11041653;
CC Q8ND90; Q7Z4V0: ZNF438; NbExp=3; IntAct=EBI-302345, EBI-11962468;
CC Q8ND90; Q8TBZ8: ZNF564; NbExp=3; IntAct=EBI-302345, EBI-10273713;
CC Q8ND90; Q9P0T4: ZNF581; NbExp=8; IntAct=EBI-302345, EBI-745520;
CC Q8ND90; A0A0S2Z5X4: ZNF688; NbExp=3; IntAct=EBI-302345, EBI-16429014;
CC Q8ND90; Q6ZN96; NbExp=6; IntAct=EBI-302345, EBI-10255097;
CC Q8ND90; PRO_0000449633 [P0DTD1]: rep; Xeno; NbExp=3; IntAct=EBI-302345, EBI-25492395;
CC -!- SUBCELLULAR LOCATION: Nucleus, nucleolus {ECO:0000269|PubMed:10050892}.
CC Note=In tumor cells, it is cytoplasmic.
CC -!- TISSUE SPECIFICITY: Testis- and brain-specific. In some cancer
CC patients, specifically expressed by paraneoplastic tumor cells.
CC {ECO:0000269|PubMed:10050892, ECO:0000269|PubMed:19366867}.
CC -!- MISCELLANEOUS: Antibodies against PNMA1 are present in sera from
CC patients suffering of paraneoplastic neurological disorders.
CC -!- SIMILARITY: Belongs to the PNMA family. {ECO:0000305}.
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DR EMBL; AF037364; AAD13810.3; -; mRNA.
DR EMBL; AF320308; AAN05100.1; -; mRNA.
DR EMBL; AK290980; BAF83669.1; -; mRNA.
DR EMBL; CH471061; EAW81126.1; -; Genomic_DNA.
DR EMBL; BC039577; AAH39577.1; -; mRNA.
DR EMBL; AL834327; CAD38995.1; -; mRNA.
DR CCDS; CCDS9818.1; -.
DR RefSeq; NP_006020.4; NM_006029.4.
DR AlphaFoldDB; Q8ND90; -.
DR SMR; Q8ND90; -.
DR BioGRID; 114667; 184.
DR IntAct; Q8ND90; 189.
DR MINT; Q8ND90; -.
DR STRING; 9606.ENSP00000318914; -.
DR iPTMnet; Q8ND90; -.
DR PhosphoSitePlus; Q8ND90; -.
DR BioMuta; PNMA1; -.
DR DMDM; 37999715; -.
DR EPD; Q8ND90; -.
DR jPOST; Q8ND90; -.
DR MassIVE; Q8ND90; -.
DR MaxQB; Q8ND90; -.
DR PaxDb; Q8ND90; -.
DR PeptideAtlas; Q8ND90; -.
DR PRIDE; Q8ND90; -.
DR ProteomicsDB; 72992; -.
DR Antibodypedia; 26; 199 antibodies from 26 providers.
DR DNASU; 9240; -.
DR Ensembl; ENST00000316836.5; ENSP00000318914.3; ENSG00000176903.5.
DR GeneID; 9240; -.
DR KEGG; hsa:9240; -.
DR MANE-Select; ENST00000316836.5; ENSP00000318914.3; NM_006029.5; NP_006020.4.
DR UCSC; uc001xor.2; human.
DR CTD; 9240; -.
DR DisGeNET; 9240; -.
DR GeneCards; PNMA1; -.
DR HGNC; HGNC:9158; PNMA1.
DR HPA; ENSG00000176903; Low tissue specificity.
DR MIM; 604010; gene.
DR neXtProt; NX_Q8ND90; -.
DR OpenTargets; ENSG00000176903; -.
DR PharmGKB; PA33481; -.
DR VEuPathDB; HostDB:ENSG00000176903; -.
DR eggNOG; ENOG502SPHT; Eukaryota.
DR GeneTree; ENSGT01030000234522; -.
DR HOGENOM; CLU_014694_0_0_1; -.
DR InParanoid; Q8ND90; -.
DR OMA; EHTNEVM; -.
DR OrthoDB; 820525at2759; -.
DR PhylomeDB; Q8ND90; -.
DR TreeFam; TF335054; -.
DR PathwayCommons; Q8ND90; -.
DR SignaLink; Q8ND90; -.
DR BioGRID-ORCS; 9240; 18 hits in 1070 CRISPR screens.
DR ChiTaRS; PNMA1; human.
DR GenomeRNAi; 9240; -.
DR Pharos; Q8ND90; Tbio.
DR PRO; PR:Q8ND90; -.
DR Proteomes; UP000005640; Chromosome 14.
DR RNAct; Q8ND90; protein.
DR Bgee; ENSG00000176903; Expressed in cortical plate and 98 other tissues.
DR Genevisible; Q8ND90; HS.
DR GO; GO:0005737; C:cytoplasm; IDA:UniProtKB.
DR GO; GO:0005829; C:cytosol; IDA:HPA.
DR GO; GO:0005730; C:nucleolus; IDA:UniProtKB.
DR GO; GO:0005654; C:nucleoplasm; IDA:HPA.
DR GO; GO:0002437; P:inflammatory response to antigenic stimulus; ISS:UniProtKB.
DR GO; GO:0043065; P:positive regulation of apoptotic process; ISS:UniProtKB.
DR InterPro; IPR026523; PNMA.
DR InterPro; IPR026528; PNMA1.
DR PANTHER; PTHR23095; PTHR23095; 1.
DR PANTHER; PTHR23095:SF17; PTHR23095:SF17; 1.
DR Pfam; PF14893; PNMA; 1.
PE 1: Evidence at protein level;
KW Nucleus; Reference proteome; Tumor antigen.
FT CHAIN 1..353
FT /note="Paraneoplastic antigen Ma1"
FT /id="PRO_0000155199"
FT VARIANT 54
FT /note="M -> V (in dbSNP:rs35129712)"
FT /id="VAR_053595"
FT VARIANT 215
FT /note="R -> P (in dbSNP:rs34413931)"
FT /id="VAR_053596"
SQ SEQUENCE 353 AA; 39761 MW; EB7F5B6AEDA25961 CRC64;
MAMTLLEDWC RGMDVNSQRA LLVWGIPVNC DEAEIEETLQ AAMPQVSYRM LGRMFWREEN
AKAALLELTG AVDYAAIPRE MPGKGGVWKV LFKPPTSDAE FLERLHLFLA REGWTVQDVA
RVLGFQNPTP TPGPEMPAEM LNYILDNVIQ PLVESIWYKR LTLFSGRDIP GPGEETFDPW
LEHTNEVLEE WQVSDVEKRR RLMESLRGPA ADVIRILKSN NPAITTAECL KALEQVFGSV
ESSRDAQIKF LNTYQNPGEK LSAYVIRLEP LLQKVVEKGA IDKDNVNQAR LEQVIAGANH
SGAIRRQLWL TGAGEGPAPN LFQLLVQIRE EEAKEEEEEA EATLLQLGLE GHF
