ID   PNMA1_MOUSE             Reviewed;         353 AA.
AC   Q8C1C8; Q3UVU2; Q9CYP2;
DT   24-OCT-2003, integrated into UniProtKB/Swiss-Prot.
DT   27-JUL-2011, sequence version 2.
DT   03-AUG-2022, entry version 104.
DE   RecName: Full=Paraneoplastic antigen Ma1 homolog;
GN   Name=Pnma1; Synonyms=Ma1;
OS   Mus musculus (Mouse).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC   Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae;
OC   Murinae; Mus; Mus.
OX   NCBI_TaxID=10090;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
RC   STRAIN=C57BL/6J; TISSUE=Brain, Diencephalon, and Embryo;
RX   PubMed=16141072; DOI=10.1126/science.1112014;
RA   Carninci P., Kasukawa T., Katayama S., Gough J., Frith M.C., Maeda N.,
RA   Oyama R., Ravasi T., Lenhard B., Wells C., Kodzius R., Shimokawa K.,
RA   Bajic V.B., Brenner S.E., Batalov S., Forrest A.R., Zavolan M., Davis M.J.,
RA   Wilming L.G., Aidinis V., Allen J.E., Ambesi-Impiombato A., Apweiler R.,
RA   Aturaliya R.N., Bailey T.L., Bansal M., Baxter L., Beisel K.W., Bersano T.,
RA   Bono H., Chalk A.M., Chiu K.P., Choudhary V., Christoffels A.,
RA   Clutterbuck D.R., Crowe M.L., Dalla E., Dalrymple B.P., de Bono B.,
RA   Della Gatta G., di Bernardo D., Down T., Engstrom P., Fagiolini M.,
RA   Faulkner G., Fletcher C.F., Fukushima T., Furuno M., Futaki S.,
RA   Gariboldi M., Georgii-Hemming P., Gingeras T.R., Gojobori T., Green R.E.,
RA   Gustincich S., Harbers M., Hayashi Y., Hensch T.K., Hirokawa N., Hill D.,
RA   Huminiecki L., Iacono M., Ikeo K., Iwama A., Ishikawa T., Jakt M.,
RA   Kanapin A., Katoh M., Kawasawa Y., Kelso J., Kitamura H., Kitano H.,
RA   Kollias G., Krishnan S.P., Kruger A., Kummerfeld S.K., Kurochkin I.V.,
RA   Lareau L.F., Lazarevic D., Lipovich L., Liu J., Liuni S., McWilliam S.,
RA   Madan Babu M., Madera M., Marchionni L., Matsuda H., Matsuzawa S., Miki H.,
RA   Mignone F., Miyake S., Morris K., Mottagui-Tabar S., Mulder N., Nakano N.,
RA   Nakauchi H., Ng P., Nilsson R., Nishiguchi S., Nishikawa S., Nori F.,
RA   Ohara O., Okazaki Y., Orlando V., Pang K.C., Pavan W.J., Pavesi G.,
RA   Pesole G., Petrovsky N., Piazza S., Reed J., Reid J.F., Ring B.Z.,
RA   Ringwald M., Rost B., Ruan Y., Salzberg S.L., Sandelin A., Schneider C.,
RA   Schoenbach C., Sekiguchi K., Semple C.A., Seno S., Sessa L., Sheng Y.,
RA   Shibata Y., Shimada H., Shimada K., Silva D., Sinclair B., Sperling S.,
RA   Stupka E., Sugiura K., Sultana R., Takenaka Y., Taki K., Tammoja K.,
RA   Tan S.L., Tang S., Taylor M.S., Tegner J., Teichmann S.A., Ueda H.R.,
RA   van Nimwegen E., Verardo R., Wei C.L., Yagi K., Yamanishi H.,
RA   Zabarovsky E., Zhu S., Zimmer A., Hide W., Bult C., Grimmond S.M.,
RA   Teasdale R.D., Liu E.T., Brusic V., Quackenbush J., Wahlestedt C.,
RA   Mattick J.S., Hume D.A., Kai C., Sasaki D., Tomaru Y., Fukuda S.,
RA   Kanamori-Katayama M., Suzuki M., Aoki J., Arakawa T., Iida J., Imamura K.,
RA   Itoh M., Kato T., Kawaji H., Kawagashira N., Kawashima T., Kojima M.,
RA   Kondo S., Konno H., Nakano K., Ninomiya N., Nishio T., Okada M., Plessy C.,
RA   Shibata K., Shiraki T., Suzuki S., Tagami M., Waki K., Watahiki A.,
RA   Okamura-Oho Y., Suzuki H., Kawai J., Hayashizaki Y.;
RT   "The transcriptional landscape of the mammalian genome.";
RL   Science 309:1559-1563(2005).
RN   [2]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RA   Mural R.J., Adams M.D., Myers E.W., Smith H.O., Venter J.C.;
RL   Submitted (JUL-2005) to the EMBL/GenBank/DDBJ databases.
RN   [3]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
RX   PubMed=15489334; DOI=10.1101/gr.2596504;
RG   The MGC Project Team;
RT   "The status, quality, and expansion of the NIH full-length cDNA project:
RT   the Mammalian Gene Collection (MGC).";
RL   Genome Res. 14:2121-2127(2004).
RN   [4]
RP   TISSUE SPECIFICITY.
RX   PubMed=19366867; DOI=10.1093/cercor/bhp062;
RA   Takaji M., Komatsu Y., Watakabe A., Hashikawa T., Yamamori T.;
RT   "Paraneoplastic antigen-like 5 gene (PNMA5) is preferentially expressed in
RT   the association areas in a primate specific manner.";
RL   Cereb. Cortex 19:2865-2879(2009).
RN   [5]
RP   IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
RC   TISSUE=Testis;
RX   PubMed=21183079; DOI=10.1016/j.cell.2010.12.001;
RA   Huttlin E.L., Jedrychowski M.P., Elias J.E., Goswami T., Rad R.,
RA   Beausoleil S.A., Villen J., Haas W., Sowa M.E., Gygi S.P.;
RT   "A tissue-specific atlas of mouse protein phosphorylation and expression.";
RL   Cell 143:1174-1189(2010).
CC   -!- SUBCELLULAR LOCATION: Nucleus, nucleolus {ECO:0000250}.
CC   -!- TISSUE SPECIFICITY: Predominantly expressed in testis. Very low levels
CC       in the brain, including in the piriform cortex, hippocampus and some
CC       subcortical nuclei. {ECO:0000269|PubMed:19366867}.
CC   -!- SIMILARITY: Belongs to the PNMA family. {ECO:0000305}.
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DR   EMBL; AK017476; BAB30762.1; -; mRNA.
DR   EMBL; AK028331; BAC25885.1; -; mRNA.
DR   EMBL; AK136933; BAE23177.1; -; mRNA.
DR   EMBL; CH466590; EDL02765.1; -; Genomic_DNA.
DR   EMBL; BC116687; AAI16688.1; -; mRNA.
DR   EMBL; BC116688; AAI16689.1; -; mRNA.
DR   CCDS; CCDS26040.1; -.
DR   RefSeq; NP_081714.2; NM_027438.3.
DR   AlphaFoldDB; Q8C1C8; -.
DR   SMR; Q8C1C8; -.
DR   BioGRID; 214084; 1.
DR   STRING; 10090.ENSMUSP00000060783; -.
DR   PhosphoSitePlus; Q8C1C8; -.
DR   PaxDb; Q8C1C8; -.
DR   PRIDE; Q8C1C8; -.
DR   ProteomicsDB; 289637; -.
DR   Antibodypedia; 26; 199 antibodies from 26 providers.
DR   DNASU; 70481; -.
DR   Ensembl; ENSMUST00000061425; ENSMUSP00000060783; ENSMUSG00000054383.
DR   GeneID; 70481; -.
DR   KEGG; mmu:70481; -.
DR   UCSC; uc007oel.1; mouse.
DR   CTD; 9240; -.
DR   MGI; MGI:2180564; Pnma1.
DR   VEuPathDB; HostDB:ENSMUSG00000054383; -.
DR   eggNOG; ENOG502SPHT; Eukaryota.
DR   GeneTree; ENSGT01030000234522; -.
DR   HOGENOM; CLU_014694_0_0_1; -.
DR   InParanoid; Q8C1C8; -.
DR   OMA; EHTNEVM; -.
DR   OrthoDB; 820525at2759; -.
DR   PhylomeDB; Q8C1C8; -.
DR   TreeFam; TF335054; -.
DR   BioGRID-ORCS; 70481; 1 hit in 71 CRISPR screens.
DR   PRO; PR:Q8C1C8; -.
DR   Proteomes; UP000000589; Chromosome 12.
DR   RNAct; Q8C1C8; protein.
DR   Bgee; ENSMUSG00000054383; Expressed in spermatocyte and 49 other tissues.
DR   Genevisible; Q8C1C8; MM.
DR   GO; GO:0005737; C:cytoplasm; ISS:UniProtKB.
DR   GO; GO:0005829; C:cytosol; ISO:MGI.
DR   GO; GO:0005730; C:nucleolus; ISS:UniProtKB.
DR   GO; GO:0005654; C:nucleoplasm; ISO:MGI.
DR   GO; GO:0002437; P:inflammatory response to antigenic stimulus; ISS:UniProtKB.
DR   InterPro; IPR026523; PNMA.
DR   InterPro; IPR026528; PNMA1.
DR   PANTHER; PTHR23095; PTHR23095; 1.
DR   PANTHER; PTHR23095:SF17; PTHR23095:SF17; 1.
DR   Pfam; PF14893; PNMA; 1.
PE   1: Evidence at protein level;
KW   Nucleus; Reference proteome.
FT   CHAIN           1..353
FT                   /note="Paraneoplastic antigen Ma1 homolog"
FT                   /id="PRO_0000155200"
FT   CONFLICT        136
FT                   /note="M -> T (in Ref. 1; BAC25885)"
FT                   /evidence="ECO:0000305"
SQ   SEQUENCE   353 AA;  39718 MW;  F7B27378B8469675 CRC64;
     MAMTLLEDWC RGMDVNSQRA LLVWGIPVNC DETEIEETLQ AAMPQVSYRV LGRMFWREEN
     AKAALLELTG AVDYSLIPRE MPGKGGLWKV VFKPPTSDAV FLERLHLFLA REGWTVQDVA
     RVLGFQNPAP APGPEMPAEM LNYILDNVIQ PLVESIWYKK LTLFSGKDIP GPGEETFDSW
     LEHSNEIIEE WQVSDIEKRR RLMESLRGPA ADVIRILKTN NAAITTAECL KALEQVFGSV
     ESSRDAQVRF LNTYQNPGEK LSSYVIRLEP LLQKVVDKGV IDKDNVNQAR LEQVIAGANH
     SGALRRQLWL AGAEEGPAPN LFQLLVQIRE EEAKKEEEEA EAALLQLGLE GHF