ID   PNMA2_MOUSE             Reviewed;         365 AA.
AC   Q8BHK0;
DT   24-OCT-2003, integrated into UniProtKB/Swiss-Prot.
DT   01-MAR-2003, sequence version 1.
DT   03-AUG-2022, entry version 117.
DE   RecName: Full=Paraneoplastic antigen Ma2 homolog;
GN   Name=Pnma2;
OS   Mus musculus (Mouse).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC   Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae;
OC   Murinae; Mus; Mus.
OX   NCBI_TaxID=10090;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
RC   STRAIN=C57BL/6J; TISSUE=Brain cortex;
RX   PubMed=16141072; DOI=10.1126/science.1112014;
RA   Carninci P., Kasukawa T., Katayama S., Gough J., Frith M.C., Maeda N.,
RA   Oyama R., Ravasi T., Lenhard B., Wells C., Kodzius R., Shimokawa K.,
RA   Bajic V.B., Brenner S.E., Batalov S., Forrest A.R., Zavolan M., Davis M.J.,
RA   Wilming L.G., Aidinis V., Allen J.E., Ambesi-Impiombato A., Apweiler R.,
RA   Aturaliya R.N., Bailey T.L., Bansal M., Baxter L., Beisel K.W., Bersano T.,
RA   Bono H., Chalk A.M., Chiu K.P., Choudhary V., Christoffels A.,
RA   Clutterbuck D.R., Crowe M.L., Dalla E., Dalrymple B.P., de Bono B.,
RA   Della Gatta G., di Bernardo D., Down T., Engstrom P., Fagiolini M.,
RA   Faulkner G., Fletcher C.F., Fukushima T., Furuno M., Futaki S.,
RA   Gariboldi M., Georgii-Hemming P., Gingeras T.R., Gojobori T., Green R.E.,
RA   Gustincich S., Harbers M., Hayashi Y., Hensch T.K., Hirokawa N., Hill D.,
RA   Huminiecki L., Iacono M., Ikeo K., Iwama A., Ishikawa T., Jakt M.,
RA   Kanapin A., Katoh M., Kawasawa Y., Kelso J., Kitamura H., Kitano H.,
RA   Kollias G., Krishnan S.P., Kruger A., Kummerfeld S.K., Kurochkin I.V.,
RA   Lareau L.F., Lazarevic D., Lipovich L., Liu J., Liuni S., McWilliam S.,
RA   Madan Babu M., Madera M., Marchionni L., Matsuda H., Matsuzawa S., Miki H.,
RA   Mignone F., Miyake S., Morris K., Mottagui-Tabar S., Mulder N., Nakano N.,
RA   Nakauchi H., Ng P., Nilsson R., Nishiguchi S., Nishikawa S., Nori F.,
RA   Ohara O., Okazaki Y., Orlando V., Pang K.C., Pavan W.J., Pavesi G.,
RA   Pesole G., Petrovsky N., Piazza S., Reed J., Reid J.F., Ring B.Z.,
RA   Ringwald M., Rost B., Ruan Y., Salzberg S.L., Sandelin A., Schneider C.,
RA   Schoenbach C., Sekiguchi K., Semple C.A., Seno S., Sessa L., Sheng Y.,
RA   Shibata Y., Shimada H., Shimada K., Silva D., Sinclair B., Sperling S.,
RA   Stupka E., Sugiura K., Sultana R., Takenaka Y., Taki K., Tammoja K.,
RA   Tan S.L., Tang S., Taylor M.S., Tegner J., Teichmann S.A., Ueda H.R.,
RA   van Nimwegen E., Verardo R., Wei C.L., Yagi K., Yamanishi H.,
RA   Zabarovsky E., Zhu S., Zimmer A., Hide W., Bult C., Grimmond S.M.,
RA   Teasdale R.D., Liu E.T., Brusic V., Quackenbush J., Wahlestedt C.,
RA   Mattick J.S., Hume D.A., Kai C., Sasaki D., Tomaru Y., Fukuda S.,
RA   Kanamori-Katayama M., Suzuki M., Aoki J., Arakawa T., Iida J., Imamura K.,
RA   Itoh M., Kato T., Kawaji H., Kawagashira N., Kawashima T., Kojima M.,
RA   Kondo S., Konno H., Nakano K., Ninomiya N., Nishio T., Okada M., Plessy C.,
RA   Shibata K., Shiraki T., Suzuki S., Tagami M., Waki K., Watahiki A.,
RA   Okamura-Oho Y., Suzuki H., Kawai J., Hayashizaki Y.;
RT   "The transcriptional landscape of the mammalian genome.";
RL   Science 309:1559-1563(2005).
RN   [2]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
RC   STRAIN=C57BL/6J; TISSUE=Brain;
RX   PubMed=15489334; DOI=10.1101/gr.2596504;
RG   The MGC Project Team;
RT   "The status, quality, and expansion of the NIH full-length cDNA project:
RT   the Mammalian Gene Collection (MGC).";
RL   Genome Res. 14:2121-2127(2004).
RN   [3]
RP   TISSUE SPECIFICITY.
RX   PubMed=19366867; DOI=10.1093/cercor/bhp062;
RA   Takaji M., Komatsu Y., Watakabe A., Hashikawa T., Yamamori T.;
RT   "Paraneoplastic antigen-like 5 gene (PNMA5) is preferentially expressed in
RT   the association areas in a primate specific manner.";
RL   Cereb. Cortex 19:2865-2879(2009).
CC   -!- SUBCELLULAR LOCATION: Nucleus, nucleolus {ECO:0000250}.
CC   -!- TISSUE SPECIFICITY: Expressed in the cerebrum, cerebellum and testis.
CC       {ECO:0000269|PubMed:19366867}.
CC   -!- SIMILARITY: Belongs to the PNMA family. {ECO:0000305}.
CC   ---------------------------------------------------------------------------
CC   Copyrighted by the UniProt Consortium, see https://www.uniprot.org/terms
CC   Distributed under the Creative Commons Attribution (CC BY 4.0) License
CC   ---------------------------------------------------------------------------
DR   EMBL; AK043718; BAC31626.1; -; mRNA.
DR   EMBL; AK043910; BAC31700.1; -; mRNA.
DR   EMBL; BC065116; AAH65116.1; -; mRNA.
DR   CCDS; CCDS27226.1; -.
DR   RefSeq; NP_780707.1; NM_175498.4.
DR   RefSeq; XP_006519052.1; XM_006518989.3.
DR   RefSeq; XP_006519053.1; XM_006518990.3.
DR   AlphaFoldDB; Q8BHK0; -.
DR   SMR; Q8BHK0; -.
DR   IntAct; Q8BHK0; 1.
DR   MINT; Q8BHK0; -.
DR   STRING; 10090.ENSMUSP00000086646; -.
DR   PhosphoSitePlus; Q8BHK0; -.
DR   PaxDb; Q8BHK0; -.
DR   PRIDE; Q8BHK0; -.
DR   ProteomicsDB; 289351; -.
DR   Antibodypedia; 35067; 184 antibodies from 24 providers.
DR   DNASU; 239157; -.
DR   Ensembl; ENSMUST00000089236; ENSMUSP00000086646; ENSMUSG00000046204.
DR   Ensembl; ENSMUST00000122431; ENSMUSP00000112629; ENSMUSG00000046204.
DR   GeneID; 239157; -.
DR   KEGG; mmu:239157; -.
DR   UCSC; uc007ukq.2; mouse.
DR   CTD; 10687; -.
DR   MGI; MGI:2444129; Pnma2.
DR   VEuPathDB; HostDB:ENSMUSG00000046204; -.
DR   eggNOG; ENOG502RWTN; Eukaryota.
DR   GeneTree; ENSGT01030000234522; -.
DR   HOGENOM; CLU_014694_0_0_1; -.
DR   InParanoid; Q8BHK0; -.
DR   OMA; DWCRIMS; -.
DR   OrthoDB; 820525at2759; -.
DR   PhylomeDB; Q8BHK0; -.
DR   TreeFam; TF335054; -.
DR   BioGRID-ORCS; 239157; 0 hits in 71 CRISPR screens.
DR   ChiTaRS; Pnma2; mouse.
DR   PRO; PR:Q8BHK0; -.
DR   Proteomes; UP000000589; Chromosome 14.
DR   RNAct; Q8BHK0; protein.
DR   Bgee; ENSMUSG00000046204; Expressed in ventromedial nucleus of hypothalamus and 117 other tissues.
DR   Genevisible; Q8BHK0; MM.
DR   GO; GO:0005730; C:nucleolus; IEA:UniProtKB-SubCell.
DR   InterPro; IPR026523; PNMA.
DR   InterPro; IPR026525; PNMA2.
DR   PANTHER; PTHR23095; PTHR23095; 1.
DR   PANTHER; PTHR23095:SF16; PTHR23095:SF16; 1.
DR   Pfam; PF14893; PNMA; 1.
PE   2: Evidence at transcript level;
KW   Acetylation; Nucleus; Reference proteome.
FT   INIT_MET        1
FT                   /note="Removed"
FT                   /evidence="ECO:0000250|UniProtKB:Q9UL42"
FT   CHAIN           2..365
FT                   /note="Paraneoplastic antigen Ma2 homolog"
FT                   /id="PRO_0000155204"
FT   REGION          336..365
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   MOD_RES         2
FT                   /note="N-acetylalanine"
FT                   /evidence="ECO:0000250|UniProtKB:Q9UL42"
SQ   SEQUENCE   365 AA;  41201 MW;  0F90C940B9D843D9 CRC64;
     MAVALLEEWC KIMGVDVQKS LLVVDIPVDC GEPEIQTVLQ EALKCVGSYR LLGKIFQKQD
     NTSVVLVELM EDTDMSVVPS EVQGKGGVWK VIFKTPNQDT EFLQRLNLFL EKEGQTVAGM
     FRALKHEGVS PATPPCTSPE LLAHLTGQAM VHGQRPLLPV KYCKMRIFSG STAAAPEEEP
     FEVWLEQATE IAKEWPIPEA EKKRWVAESL RGPALDLMHI VQADNPSISV GECLEAFKQV
     FGSTESRRTS QVKYLRTYQQ EGEKISAYVL RLETLLRRAV EKRAIPRNIA DQVRLEQVMA
     GANLGNVLWC RLQELKDQGP LPTFLQLMKV IREEEEEEDA YFEQESREEP GEREGSGCWN
     NSRNN