PNMA3_MOUSE
ID PNMA3_MOUSE Reviewed; 466 AA.
AC Q8JZW8; Q3URF3;
DT 20-MAR-2007, integrated into UniProtKB/Swiss-Prot.
DT 01-OCT-2002, sequence version 1.
DT 03-AUG-2022, entry version 124.
DE RecName: Full=Paraneoplastic antigen Ma3 homolog;
GN Name=Pnma3;
OS Mus musculus (Mouse).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae;
OC Murinae; Mus; Mus.
OX NCBI_TaxID=10090;
RN [1]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=C57BL/6J;
RX PubMed=19468303; DOI=10.1371/journal.pbio.1000112;
RA Church D.M., Goodstadt L., Hillier L.W., Zody M.C., Goldstein S., She X.,
RA Bult C.J., Agarwala R., Cherry J.L., DiCuccio M., Hlavina W., Kapustin Y.,
RA Meric P., Maglott D., Birtle Z., Marques A.C., Graves T., Zhou S.,
RA Teague B., Potamousis K., Churas C., Place M., Herschleb J., Runnheim R.,
RA Forrest D., Amos-Landgraf J., Schwartz D.C., Cheng Z., Lindblad-Toh K.,
RA Eichler E.E., Ponting C.P.;
RT "Lineage-specific biology revealed by a finished genome assembly of the
RT mouse.";
RL PLoS Biol. 7:E1000112-E1000112(2009).
RN [2]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
RC TISSUE=Eye;
RX PubMed=15489334; DOI=10.1101/gr.2596504;
RG The MGC Project Team;
RT "The status, quality, and expansion of the NIH full-length cDNA project:
RT the Mammalian Gene Collection (MGC).";
RL Genome Res. 14:2121-2127(2004).
RN [3]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] OF 167-466.
RC STRAIN=C57BL/6J; TISSUE=Hippocampus;
RX PubMed=16141072; DOI=10.1126/science.1112014;
RA Carninci P., Kasukawa T., Katayama S., Gough J., Frith M.C., Maeda N.,
RA Oyama R., Ravasi T., Lenhard B., Wells C., Kodzius R., Shimokawa K.,
RA Bajic V.B., Brenner S.E., Batalov S., Forrest A.R., Zavolan M., Davis M.J.,
RA Wilming L.G., Aidinis V., Allen J.E., Ambesi-Impiombato A., Apweiler R.,
RA Aturaliya R.N., Bailey T.L., Bansal M., Baxter L., Beisel K.W., Bersano T.,
RA Bono H., Chalk A.M., Chiu K.P., Choudhary V., Christoffels A.,
RA Clutterbuck D.R., Crowe M.L., Dalla E., Dalrymple B.P., de Bono B.,
RA Della Gatta G., di Bernardo D., Down T., Engstrom P., Fagiolini M.,
RA Faulkner G., Fletcher C.F., Fukushima T., Furuno M., Futaki S.,
RA Gariboldi M., Georgii-Hemming P., Gingeras T.R., Gojobori T., Green R.E.,
RA Gustincich S., Harbers M., Hayashi Y., Hensch T.K., Hirokawa N., Hill D.,
RA Huminiecki L., Iacono M., Ikeo K., Iwama A., Ishikawa T., Jakt M.,
RA Kanapin A., Katoh M., Kawasawa Y., Kelso J., Kitamura H., Kitano H.,
RA Kollias G., Krishnan S.P., Kruger A., Kummerfeld S.K., Kurochkin I.V.,
RA Lareau L.F., Lazarevic D., Lipovich L., Liu J., Liuni S., McWilliam S.,
RA Madan Babu M., Madera M., Marchionni L., Matsuda H., Matsuzawa S., Miki H.,
RA Mignone F., Miyake S., Morris K., Mottagui-Tabar S., Mulder N., Nakano N.,
RA Nakauchi H., Ng P., Nilsson R., Nishiguchi S., Nishikawa S., Nori F.,
RA Ohara O., Okazaki Y., Orlando V., Pang K.C., Pavan W.J., Pavesi G.,
RA Pesole G., Petrovsky N., Piazza S., Reed J., Reid J.F., Ring B.Z.,
RA Ringwald M., Rost B., Ruan Y., Salzberg S.L., Sandelin A., Schneider C.,
RA Schoenbach C., Sekiguchi K., Semple C.A., Seno S., Sessa L., Sheng Y.,
RA Shibata Y., Shimada H., Shimada K., Silva D., Sinclair B., Sperling S.,
RA Stupka E., Sugiura K., Sultana R., Takenaka Y., Taki K., Tammoja K.,
RA Tan S.L., Tang S., Taylor M.S., Tegner J., Teichmann S.A., Ueda H.R.,
RA van Nimwegen E., Verardo R., Wei C.L., Yagi K., Yamanishi H.,
RA Zabarovsky E., Zhu S., Zimmer A., Hide W., Bult C., Grimmond S.M.,
RA Teasdale R.D., Liu E.T., Brusic V., Quackenbush J., Wahlestedt C.,
RA Mattick J.S., Hume D.A., Kai C., Sasaki D., Tomaru Y., Fukuda S.,
RA Kanamori-Katayama M., Suzuki M., Aoki J., Arakawa T., Iida J., Imamura K.,
RA Itoh M., Kato T., Kawaji H., Kawagashira N., Kawashima T., Kojima M.,
RA Kondo S., Konno H., Nakano K., Ninomiya N., Nishio T., Okada M., Plessy C.,
RA Shibata K., Shiraki T., Suzuki S., Tagami M., Waki K., Watahiki A.,
RA Okamura-Oho Y., Suzuki H., Kawai J., Hayashizaki Y.;
RT "The transcriptional landscape of the mammalian genome.";
RL Science 309:1559-1563(2005).
RN [4]
RP TISSUE SPECIFICITY.
RX PubMed=19366867; DOI=10.1093/cercor/bhp062;
RA Takaji M., Komatsu Y., Watakabe A., Hashikawa T., Yamamori T.;
RT "Paraneoplastic antigen-like 5 gene (PNMA5) is preferentially expressed in
RT the association areas in a primate specific manner.";
RL Cereb. Cortex 19:2865-2879(2009).
CC -!- SUBCELLULAR LOCATION: Nucleus, nucleolus {ECO:0000250}.
CC -!- TISSUE SPECIFICITY: Expressed in the cerebrum and cerebellum.
CC {ECO:0000269|PubMed:19366867}.
CC -!- SIMILARITY: Belongs to the PNMA family. {ECO:0000305}.
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DR EMBL; BX813330; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR EMBL; BC036726; AAH36726.1; -; mRNA.
DR EMBL; AK141560; BAE24735.1; -; mRNA.
DR CCDS; CCDS30192.1; -.
DR RefSeq; NP_694809.1; NM_153169.2.
DR AlphaFoldDB; Q8JZW8; -.
DR SMR; Q8JZW8; -.
DR STRING; 10090.ENSMUSP00000054177; -.
DR iPTMnet; Q8JZW8; -.
DR PhosphoSitePlus; Q8JZW8; -.
DR PaxDb; Q8JZW8; -.
DR PRIDE; Q8JZW8; -.
DR ProteomicsDB; 289352; -.
DR Antibodypedia; 45169; 201 antibodies from 14 providers.
DR DNASU; 245468; -.
DR Ensembl; ENSMUST00000060418; ENSMUSP00000054177; ENSMUSG00000046287.
DR GeneID; 245468; -.
DR KEGG; mmu:245468; -.
DR UCSC; uc009tla.1; mouse.
DR CTD; 29944; -.
DR MGI; MGI:2180565; Pnma3.
DR VEuPathDB; HostDB:ENSMUSG00000046287; -.
DR eggNOG; ENOG502SKT0; Eukaryota.
DR GeneTree; ENSGT01030000234522; -.
DR HOGENOM; CLU_014694_0_1_1; -.
DR InParanoid; Q8JZW8; -.
DR OMA; NCPAPRV; -.
DR OrthoDB; 820525at2759; -.
DR PhylomeDB; Q8JZW8; -.
DR TreeFam; TF335054; -.
DR BioGRID-ORCS; 245468; 0 hits in 71 CRISPR screens.
DR ChiTaRS; Pnma3; mouse.
DR PRO; PR:Q8JZW8; -.
DR Proteomes; UP000000589; Chromosome X.
DR RNAct; Q8JZW8; protein.
DR Bgee; ENSMUSG00000046287; Expressed in lumbar subsegment of spinal cord and 43 other tissues.
DR Genevisible; Q8JZW8; MM.
DR GO; GO:0005730; C:nucleolus; IEA:UniProtKB-SubCell.
DR GO; GO:0003676; F:nucleic acid binding; IEA:InterPro.
DR GO; GO:0008270; F:zinc ion binding; IEA:InterPro.
DR InterPro; IPR026523; PNMA.
DR InterPro; IPR026529; PNMA3.
DR InterPro; IPR001878; Znf_CCHC.
DR PANTHER; PTHR23095; PTHR23095; 1.
DR PANTHER; PTHR23095:SF22; PTHR23095:SF22; 1.
DR Pfam; PF14893; PNMA; 1.
DR PROSITE; PS50158; ZF_CCHC; 1.
PE 2: Evidence at transcript level;
KW Metal-binding; Nucleus; Reference proteome; Zinc; Zinc-finger.
FT CHAIN 1..466
FT /note="Paraneoplastic antigen Ma3 homolog"
FT /id="PRO_0000280216"
FT ZN_FING 415..432
FT /note="CCHC-type"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00047"
FT REGION 379..408
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 441..466
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 442..466
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 466 AA; 54041 MW; 113787E37B0B3AAD CRC64;
MPLNLLQDWC RGEHLNTQRS MLILGIPEDC SEDEFEETLH EALKHLGRYR IIGRMFRREE
NAQAFLVELA RDFDYALVPR EIEGKGGPWE VVVKPPHSDD EFLNRLNHFL EEERRTVSDM
NRVLGTHSNH SPTKTTISAD FWVWAQTLGA VMQPLLEQML YRELRVFSGN TISIPGLLAF
DSWLEHTTEM LQMWQVPEVE KRRRLMECLR GPALQVVNVL RANNAAITVK ECLEALRQVF
GSVDNRKIAQ LKFCKAYQEP GEKVSSFVVR LETLLQKALE KNAISRKNVN QTRLKRILGG
AILSAKLREK LKMLKQRRRP PGFLALVKLF REEEEEWEAT RGSERSCYEG LELGPSPSNI
GSEERELFVP AFGSVLEERP YQGSRRRRHR RRGQHRKGGV PRDDSQGTRK QNYDTFCYSC
GEDGHIRVHC FNPSNRTLVK QKRQAAMEKG NRSWAWEKSH PKPKTK
