PNMA5_HUMAN
ID PNMA5_HUMAN Reviewed; 448 AA.
AC Q96PV4; B4DI72; B7Z9Y9; Q495L5; Q8NET3;
DT 13-NOV-2007, integrated into UniProtKB/Swiss-Prot.
DT 13-NOV-2007, sequence version 2.
DT 03-AUG-2022, entry version 126.
DE RecName: Full=Paraneoplastic antigen-like protein 5;
DE AltName: Full=Tumor antigen BJ-HCC-25;
GN Name=PNMA5; Synonyms=KIAA1934;
OS Homo sapiens (Human).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae;
OC Homo.
OX NCBI_TaxID=9606;
RN [1]
RP NUCLEOTIDE SEQUENCE [MRNA].
RA Dong X.-Y., Chen W.-F.;
RT "Cloning and identification of genes which are differentially expressed in
RT carcinoma.";
RL Submitted (JUN-2002) to the EMBL/GenBank/DDBJ databases.
RN [2]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
RC TISSUE=Brain;
RX PubMed=11572484; DOI=10.1093/dnares/8.4.179;
RA Nagase T., Kikuno R., Ohara O.;
RT "Prediction of the coding sequences of unidentified human genes. XXI. The
RT complete sequences of 60 new cDNA clones from brain which code for large
RT proteins.";
RL DNA Res. 8:179-187(2001).
RN [3]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
RC TISSUE=Hippocampus;
RX PubMed=14702039; DOI=10.1038/ng1285;
RA Ota T., Suzuki Y., Nishikawa T., Otsuki T., Sugiyama T., Irie R.,
RA Wakamatsu A., Hayashi K., Sato H., Nagai K., Kimura K., Makita H.,
RA Sekine M., Obayashi M., Nishi T., Shibahara T., Tanaka T., Ishii S.,
RA Yamamoto J., Saito K., Kawai Y., Isono Y., Nakamura Y., Nagahari K.,
RA Murakami K., Yasuda T., Iwayanagi T., Wagatsuma M., Shiratori A., Sudo H.,
RA Hosoiri T., Kaku Y., Kodaira H., Kondo H., Sugawara M., Takahashi M.,
RA Kanda K., Yokoi T., Furuya T., Kikkawa E., Omura Y., Abe K., Kamihara K.,
RA Katsuta N., Sato K., Tanikawa M., Yamazaki M., Ninomiya K., Ishibashi T.,
RA Yamashita H., Murakawa K., Fujimori K., Tanai H., Kimata M., Watanabe M.,
RA Hiraoka S., Chiba Y., Ishida S., Ono Y., Takiguchi S., Watanabe S.,
RA Yosida M., Hotuta T., Kusano J., Kanehori K., Takahashi-Fujii A., Hara H.,
RA Tanase T.-O., Nomura Y., Togiya S., Komai F., Hara R., Takeuchi K.,
RA Arita M., Imose N., Musashino K., Yuuki H., Oshima A., Sasaki N.,
RA Aotsuka S., Yoshikawa Y., Matsunawa H., Ichihara T., Shiohata N., Sano S.,
RA Moriya S., Momiyama H., Satoh N., Takami S., Terashima Y., Suzuki O.,
RA Nakagawa S., Senoh A., Mizoguchi H., Goto Y., Shimizu F., Wakebe H.,
RA Hishigaki H., Watanabe T., Sugiyama A., Takemoto M., Kawakami B.,
RA Yamazaki M., Watanabe K., Kumagai A., Itakura S., Fukuzumi Y., Fujimori Y.,
RA Komiyama M., Tashiro H., Tanigami A., Fujiwara T., Ono T., Yamada K.,
RA Fujii Y., Ozaki K., Hirao M., Ohmori Y., Kawabata A., Hikiji T.,
RA Kobatake N., Inagaki H., Ikema Y., Okamoto S., Okitani R., Kawakami T.,
RA Noguchi S., Itoh T., Shigeta K., Senba T., Matsumura K., Nakajima Y.,
RA Mizuno T., Morinaga M., Sasaki M., Togashi T., Oyama M., Hata H.,
RA Watanabe M., Komatsu T., Mizushima-Sugano J., Satoh T., Shirai Y.,
RA Takahashi Y., Nakagawa K., Okumura K., Nagase T., Nomura N., Kikuchi H.,
RA Masuho Y., Yamashita R., Nakai K., Yada T., Nakamura Y., Ohara O.,
RA Isogai T., Sugano S.;
RT "Complete sequencing and characterization of 21,243 full-length human
RT cDNAs.";
RL Nat. Genet. 36:40-45(2004).
RN [4]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RA Mural R.J., Istrail S., Sutton G.G., Florea L., Halpern A.L., Mobarry C.M.,
RA Lippert R., Walenz B., Shatkay H., Dew I., Miller J.R., Flanigan M.J.,
RA Edwards N.J., Bolanos R., Fasulo D., Halldorsson B.V., Hannenhalli S.,
RA Turner R., Yooseph S., Lu F., Nusskern D.R., Shue B.C., Zheng X.H.,
RA Zhong F., Delcher A.L., Huson D.H., Kravitz S.A., Mouchard L., Reinert K.,
RA Remington K.A., Clark A.G., Waterman M.S., Eichler E.E., Adams M.D.,
RA Hunkapiller M.W., Myers E.W., Venter J.C.;
RL Submitted (SEP-2005) to the EMBL/GenBank/DDBJ databases.
RN [5]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
RX PubMed=15489334; DOI=10.1101/gr.2596504;
RG The MGC Project Team;
RT "The status, quality, and expansion of the NIH full-length cDNA project:
RT the Mammalian Gene Collection (MGC).";
RL Genome Res. 14:2121-2127(2004).
RN [6]
RP TISSUE SPECIFICITY.
RX PubMed=19366867; DOI=10.1093/cercor/bhp062;
RA Takaji M., Komatsu Y., Watakabe A., Hashikawa T., Yamamori T.;
RT "Paraneoplastic antigen-like 5 gene (PNMA5) is preferentially expressed in
RT the association areas in a primate specific manner.";
RL Cereb. Cortex 19:2865-2879(2009).
CC -!- INTERACTION:
CC Q96PV4; P68133: ACTA1; NbExp=3; IntAct=EBI-10171633, EBI-367510;
CC Q96PV4; Q9BXS5: AP1M1; NbExp=3; IntAct=EBI-10171633, EBI-541426;
CC Q96PV4; Q9UKG1: APPL1; NbExp=3; IntAct=EBI-10171633, EBI-741243;
CC Q96PV4; P59998: ARPC4; NbExp=7; IntAct=EBI-10171633, EBI-351872;
CC Q96PV4; P13637: ATP1A3; NbExp=3; IntAct=EBI-10171633, EBI-948169;
CC Q96PV4; Q6PI77: BHLHB9; NbExp=3; IntAct=EBI-10171633, EBI-11519926;
CC Q96PV4; Q9H6J7: C11orf49; NbExp=3; IntAct=EBI-10171633, EBI-721300;
CC Q96PV4; Q9H6J7-2: C11orf49; NbExp=3; IntAct=EBI-10171633, EBI-13328871;
CC Q96PV4; A2RRN7: CADPS; NbExp=3; IntAct=EBI-10171633, EBI-10179719;
CC Q96PV4; Q9H257: CARD9; NbExp=3; IntAct=EBI-10171633, EBI-751319;
CC Q96PV4; Q68D86: CCDC102B; NbExp=8; IntAct=EBI-10171633, EBI-10171570;
CC Q96PV4; P24863: CCNC; NbExp=4; IntAct=EBI-10171633, EBI-395261;
CC Q96PV4; Q9UJX2: CDC23; NbExp=3; IntAct=EBI-10171633, EBI-396137;
CC Q96PV4; Q8IYX8: CEP57L1; NbExp=3; IntAct=EBI-10171633, EBI-1104570;
CC Q96PV4; Q8IYX8-2: CEP57L1; NbExp=5; IntAct=EBI-10171633, EBI-10181988;
CC Q96PV4; P41208: CETN2; NbExp=3; IntAct=EBI-10171633, EBI-1789926;
CC Q96PV4; Q9BSW2: CRACR2A; NbExp=3; IntAct=EBI-10171633, EBI-739773;
CC Q96PV4; Q9UI47-2: CTNNA3; NbExp=3; IntAct=EBI-10171633, EBI-11962928;
CC Q96PV4; P26196: DDX6; NbExp=3; IntAct=EBI-10171633, EBI-351257;
CC Q96PV4; Q8IYY4: DZIP1L; NbExp=3; IntAct=EBI-10171633, EBI-10264440;
CC Q96PV4; Q08426: EHHADH; NbExp=3; IntAct=EBI-10171633, EBI-2339219;
CC Q96PV4; O75593: FOXH1; NbExp=3; IntAct=EBI-10171633, EBI-1759806;
CC Q96PV4; A1L4K1: FSD2; NbExp=3; IntAct=EBI-10171633, EBI-5661036;
CC Q96PV4; O95995: GAS8; NbExp=3; IntAct=EBI-10171633, EBI-1052570;
CC Q96PV4; P14136: GFAP; NbExp=3; IntAct=EBI-10171633, EBI-744302;
CC Q96PV4; A6NEM1: GOLGA6L9; NbExp=3; IntAct=EBI-10171633, EBI-5916454;
CC Q96PV4; Q9H8Y8: GORASP2; NbExp=7; IntAct=EBI-10171633, EBI-739467;
CC Q96PV4; P62993: GRB2; NbExp=3; IntAct=EBI-10171633, EBI-401755;
CC Q96PV4; P13807: GYS1; NbExp=3; IntAct=EBI-10171633, EBI-740553;
CC Q96PV4; Q86VS8: HOOK3; NbExp=3; IntAct=EBI-10171633, EBI-1777078;
CC Q96PV4; O75031: HSF2BP; NbExp=3; IntAct=EBI-10171633, EBI-7116203;
CC Q96PV4; Q9HAQ2: KIF9; NbExp=3; IntAct=EBI-10171633, EBI-8472129;
CC Q96PV4; Q9BVG8-5: KIFC3; NbExp=3; IntAct=EBI-10171633, EBI-14069005;
CC Q96PV4; P52292: KPNA2; NbExp=3; IntAct=EBI-10171633, EBI-349938;
CC Q96PV4; Q9UBR4-2: LHX3; NbExp=3; IntAct=EBI-10171633, EBI-12039345;
CC Q96PV4; Q8TBB1: LNX1; NbExp=3; IntAct=EBI-10171633, EBI-739832;
CC Q96PV4; Q9Y5V3: MAGED1; NbExp=3; IntAct=EBI-10171633, EBI-716006;
CC Q96PV4; Q96BY2: MOAP1; NbExp=3; IntAct=EBI-10171633, EBI-739825;
CC Q96PV4; Q96HA8: NTAQ1; NbExp=7; IntAct=EBI-10171633, EBI-741158;
CC Q96PV4; Q02548: PAX5; NbExp=3; IntAct=EBI-10171633, EBI-296331;
CC Q96PV4; P16284: PECAM1; NbExp=3; IntAct=EBI-10171633, EBI-716404;
CC Q96PV4; Q96T60: PNKP; NbExp=3; IntAct=EBI-10171633, EBI-1045072;
CC Q96PV4; Q8ND90: PNMA1; NbExp=6; IntAct=EBI-10171633, EBI-302345;
CC Q96PV4; Q96PV4: PNMA5; NbExp=6; IntAct=EBI-10171633, EBI-10171633;
CC Q96PV4; Q9BUI4: POLR3C; NbExp=3; IntAct=EBI-10171633, EBI-5452779;
CC Q96PV4; Q13131: PRKAA1; NbExp=4; IntAct=EBI-10171633, EBI-1181405;
CC Q96PV4; P25786: PSMA1; NbExp=3; IntAct=EBI-10171633, EBI-359352;
CC Q96PV4; P20339: RAB5A; NbExp=3; IntAct=EBI-10171633, EBI-399437;
CC Q96PV4; P54727: RAD23B; NbExp=6; IntAct=EBI-10171633, EBI-954531;
CC Q96PV4; O60504: SORBS3; NbExp=3; IntAct=EBI-10171633, EBI-741237;
CC Q96PV4; Q9NZD8: SPG21; NbExp=3; IntAct=EBI-10171633, EBI-742688;
CC Q96PV4; Q9NU19: TBC1D22B; NbExp=4; IntAct=EBI-10171633, EBI-8787464;
CC Q96PV4; Q15560: TCEA2; NbExp=3; IntAct=EBI-10171633, EBI-710310;
CC Q96PV4; Q8N8B7-2: TCEANC; NbExp=3; IntAct=EBI-10171633, EBI-11955057;
CC Q96PV4; O14787: TNPO2; NbExp=3; IntAct=EBI-10171633, EBI-431907;
CC Q96PV4; Q5W5X9: TTC23; NbExp=3; IntAct=EBI-10171633, EBI-6447954;
CC Q96PV4; Q9NX01: TXNL4B; NbExp=3; IntAct=EBI-10171633, EBI-10309345;
CC Q96PV4; P57075-2: UBASH3A; NbExp=3; IntAct=EBI-10171633, EBI-7353612;
CC Q96PV4; P08670: VIM; NbExp=6; IntAct=EBI-10171633, EBI-353844;
CC Q96PV4; Q548N1: VPS28; NbExp=3; IntAct=EBI-10171633, EBI-10243107;
CC Q96PV4; P24278: ZBTB25; NbExp=4; IntAct=EBI-10171633, EBI-739899;
CC Q96PV4; Q68DK2-5: ZFYVE26; NbExp=3; IntAct=EBI-10171633, EBI-8656416;
CC Q96PV4; Q96E35: ZMYND19; NbExp=6; IntAct=EBI-10171633, EBI-746595;
CC Q96PV4; Q9UGI0: ZRANB1; NbExp=3; IntAct=EBI-10171633, EBI-527853;
CC Q96PV4; Q5JPT6; NbExp=3; IntAct=EBI-10171633, EBI-10244213;
CC Q96PV4; Q9H614; NbExp=3; IntAct=EBI-10171633, EBI-10249899;
CC -!- TISSUE SPECIFICITY: Expressed in the brain.
CC {ECO:0000269|PubMed:19366867}.
CC -!- SIMILARITY: Belongs to the PNMA family. {ECO:0000305}.
CC -!- SEQUENCE CAUTION:
CC Sequence=BAB67827.1; Type=Erroneous initiation; Note=Extended N-terminus.; Evidence={ECO:0000305};
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DR EMBL; AY121806; AAM82754.1; -; mRNA.
DR EMBL; AB067521; BAB67827.1; ALT_INIT; mRNA.
DR EMBL; AK295446; BAG58384.1; -; mRNA.
DR EMBL; AK316104; BAH14475.1; -; mRNA.
DR EMBL; CH471172; EAW72892.1; -; Genomic_DNA.
DR EMBL; BC101111; AAI01112.1; -; mRNA.
DR EMBL; BC101112; AAI01113.1; -; mRNA.
DR EMBL; BC101113; AAI01114.1; -; mRNA.
DR CCDS; CCDS14718.1; -.
DR RefSeq; NP_001096620.1; NM_001103150.1.
DR RefSeq; NP_001096621.1; NM_001103151.1.
DR RefSeq; NP_001171853.1; NM_001184924.1.
DR RefSeq; NP_443158.1; NM_052926.2.
DR RefSeq; XP_016884741.1; XM_017029252.1.
DR RefSeq; XP_016884742.1; XM_017029253.1.
DR AlphaFoldDB; Q96PV4; -.
DR BioGRID; 125374; 70.
DR IntAct; Q96PV4; 68.
DR STRING; 9606.ENSP00000388850; -.
DR GlyGen; Q96PV4; 1 site, 1 O-linked glycan (1 site).
DR iPTMnet; Q96PV4; -.
DR PhosphoSitePlus; Q96PV4; -.
DR BioMuta; PNMA5; -.
DR DMDM; 160419235; -.
DR MassIVE; Q96PV4; -.
DR PaxDb; Q96PV4; -.
DR PeptideAtlas; Q96PV4; -.
DR PRIDE; Q96PV4; -.
DR ProteomicsDB; 77773; -.
DR Antibodypedia; 63837; 108 antibodies from 16 providers.
DR DNASU; 114824; -.
DR Ensembl; ENST00000361887.5; ENSP00000354834.5; ENSG00000198883.12.
DR Ensembl; ENST00000439251.3; ENSP00000388850.1; ENSG00000198883.12.
DR Ensembl; ENST00000452693.5; ENSP00000392342.1; ENSG00000198883.12.
DR Ensembl; ENST00000535214.6; ENSP00000445775.1; ENSG00000198883.12.
DR GeneID; 114824; -.
DR KEGG; hsa:114824; -.
DR MANE-Select; ENST00000535214.6; ENSP00000445775.1; NM_001184924.2; NP_001171853.1.
DR UCSC; uc004fgy.5; human.
DR CTD; 114824; -.
DR GeneCards; PNMA5; -.
DR HGNC; HGNC:18743; PNMA5.
DR HPA; ENSG00000198883; Group enriched (brain, testis).
DR MIM; 300916; gene.
DR neXtProt; NX_Q96PV4; -.
DR OpenTargets; ENSG00000198883; -.
DR PharmGKB; PA38668; -.
DR VEuPathDB; HostDB:ENSG00000198883; -.
DR eggNOG; ENOG502SPHT; Eukaryota.
DR GeneTree; ENSGT01030000234522; -.
DR HOGENOM; CLU_014694_0_1_1; -.
DR InParanoid; Q96PV4; -.
DR OMA; EGPQTAG; -.
DR OrthoDB; 820525at2759; -.
DR PhylomeDB; Q96PV4; -.
DR TreeFam; TF335054; -.
DR PathwayCommons; Q96PV4; -.
DR SignaLink; Q96PV4; -.
DR BioGRID-ORCS; 114824; 8 hits in 691 CRISPR screens.
DR ChiTaRS; PNMA5; human.
DR GenomeRNAi; 114824; -.
DR Pharos; Q96PV4; Tdark.
DR PRO; PR:Q96PV4; -.
DR Proteomes; UP000005640; Chromosome X.
DR RNAct; Q96PV4; protein.
DR Bgee; ENSG00000198883; Expressed in hypothalamus and 38 other tissues.
DR GO; GO:0042802; F:identical protein binding; IPI:IntAct.
DR GO; GO:0043065; P:positive regulation of apoptotic process; ISS:UniProtKB.
DR InterPro; IPR026523; PNMA.
DR InterPro; IPR026527; PNMA5.
DR PANTHER; PTHR23095; PTHR23095; 1.
DR PANTHER; PTHR23095:SF4; PTHR23095:SF4; 1.
DR Pfam; PF14893; PNMA; 1.
PE 1: Evidence at protein level;
KW Reference proteome.
FT CHAIN 1..448
FT /note="Paraneoplastic antigen-like protein 5"
FT /id="PRO_0000311217"
FT REGION 335..448
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 359..384
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 395..409
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT VARIANT 107
FT /note="N -> H (in dbSNP:rs3810655)"
FT /id="VAR_037164"
FT VARIANT 349
FT /note="R -> W (in dbSNP:rs3810654)"
FT /id="VAR_037165"
FT CONFLICT 242
FT /note="R -> G (in Ref. 5; AAI01113)"
FT /evidence="ECO:0000305"
FT CONFLICT 325
FT /note="I -> T (in Ref. 3; BAH14475)"
FT /evidence="ECO:0000305"
FT CONFLICT 359
FT /note="E -> G (in Ref. 3; BAH14475)"
FT /evidence="ECO:0000305"
SQ SEQUENCE 448 AA; 49934 MW; 5F6BC8A15B457A89 CRC64;
MALTLLEDWC KGMDMDPRKA LLIVGIPMEC SEVEIQDTVK AGLQPLCAYR VLGRMFRRED
NAKAVFIELA DTVNYTTLPS HIPGKGGSWE VVVKPRNPDD EFLSRLNYFL KDEGRSMTDV
ARALGCCSLP AESLDAEVMP QVRSPPLEPP KESMWYRKLK VFSGTASPSP GEETFEDWLE
QVTEIMPIWQ VSEVEKRRRL LESLRGPALS IMRVLQANND SITVEQCLDA LKQIFGDKED
FRASQFRFLQ TSPKIGEKVS TFLLRLEPLL QKAVHKSPLS VRSTDMIRLK HLLARVAMTP
ALRGKLELLD QRGCPPNFLE LMKLIRDEEE WENTEAVMKN KEKPSGRGRG ASGRQARAEA
SVSAPQATVQ ARSFSDSSPQ TIQGGLPPLV KRRRLLGSES TRGEDHGQAT YPKAENQTPG
REGPQAAGEE LGNEAGAGAM SHPKPWET
