PNMA5_MOUSE
ID PNMA5_MOUSE Reviewed; 618 AA.
AC Q5DTT8; A2BI36;
DT 13-NOV-2007, integrated into UniProtKB/Swiss-Prot.
DT 13-NOV-2007, sequence version 2.
DT 03-AUG-2022, entry version 94.
DE RecName: Full=Paraneoplastic antigen-like protein 5;
GN Name=Pnma5; Synonyms=Kiaa1934;
OS Mus musculus (Mouse).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae;
OC Murinae; Mus; Mus.
OX NCBI_TaxID=10090;
RN [1]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=C57BL/6J;
RX PubMed=19468303; DOI=10.1371/journal.pbio.1000112;
RA Church D.M., Goodstadt L., Hillier L.W., Zody M.C., Goldstein S., She X.,
RA Bult C.J., Agarwala R., Cherry J.L., DiCuccio M., Hlavina W., Kapustin Y.,
RA Meric P., Maglott D., Birtle Z., Marques A.C., Graves T., Zhou S.,
RA Teague B., Potamousis K., Churas C., Place M., Herschleb J., Runnheim R.,
RA Forrest D., Amos-Landgraf J., Schwartz D.C., Cheng Z., Lindblad-Toh K.,
RA Eichler E.E., Ponting C.P.;
RT "Lineage-specific biology revealed by a finished genome assembly of the
RT mouse.";
RL PLoS Biol. 7:E1000112-E1000112(2009).
RN [2]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] OF 1-447.
RC TISSUE=Brain;
RA Okazaki N., Kikuno R.F., Ohara R., Inamoto S., Nagase T., Ohara O.,
RA Koga H.;
RT "Prediction of the coding sequences of mouse homologues of KIAA gene. The
RT complete nucleotide sequences of mouse KIAA-homologous cDNAs identified by
RT screening of terminal sequences of cDNA clones randomly sampled from size-
RT fractionated libraries.";
RL Submitted (FEB-2005) to the EMBL/GenBank/DDBJ databases.
RN [3]
RP TISSUE SPECIFICITY.
RX PubMed=19366867; DOI=10.1093/cercor/bhp062;
RA Takaji M., Komatsu Y., Watakabe A., Hashikawa T., Yamamori T.;
RT "Paraneoplastic antigen-like 5 gene (PNMA5) is preferentially expressed in
RT the association areas in a primate specific manner.";
RL Cereb. Cortex 19:2865-2879(2009).
RN [4]
RP IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
RC TISSUE=Testis;
RX PubMed=21183079; DOI=10.1016/j.cell.2010.12.001;
RA Huttlin E.L., Jedrychowski M.P., Elias J.E., Goswami T., Rad R.,
RA Beausoleil S.A., Villen J., Haas W., Sowa M.E., Gygi S.P.;
RT "A tissue-specific atlas of mouse protein phosphorylation and expression.";
RL Cell 143:1174-1189(2010).
CC -!- TISSUE SPECIFICITY: Restricted to testis, where expression is low. Not
CC detected in the brain. {ECO:0000269|PubMed:19366867}.
CC -!- SIMILARITY: Belongs to the PNMA family. {ECO:0000305}.
CC -!- SEQUENCE CAUTION:
CC Sequence=BAD90475.1; Type=Erroneous initiation; Note=Extended N-terminus.; Evidence={ECO:0000305};
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DR EMBL; BX813330; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR EMBL; AK220432; BAD90475.1; ALT_INIT; mRNA.
DR CCDS; CCDS41004.1; -.
DR RefSeq; NP_001093931.1; NM_001100461.3.
DR RefSeq; XP_011245927.1; XM_011247625.2.
DR RefSeq; XP_011245928.1; XM_011247626.2.
DR AlphaFoldDB; Q5DTT8; -.
DR SMR; Q5DTT8; -.
DR STRING; 10090.ENSMUSP00000063061; -.
DR iPTMnet; Q5DTT8; -.
DR PhosphoSitePlus; Q5DTT8; -.
DR MaxQB; Q5DTT8; -.
DR PaxDb; Q5DTT8; -.
DR PRIDE; Q5DTT8; -.
DR ProteomicsDB; 289711; -.
DR Antibodypedia; 63837; 108 antibodies from 16 providers.
DR DNASU; 385377; -.
DR Ensembl; ENSMUST00000051569; ENSMUSP00000063061; ENSMUSG00000050424.
DR Ensembl; ENSMUST00000114540; ENSMUSP00000110187; ENSMUSG00000050424.
DR GeneID; 385377; -.
DR KEGG; mmu:385377; -.
DR UCSC; uc012hjz.1; mouse.
DR CTD; 114824; -.
DR MGI; MGI:2180566; Pnma5.
DR VEuPathDB; HostDB:ENSMUSG00000050424; -.
DR eggNOG; ENOG502SPHT; Eukaryota.
DR GeneTree; ENSGT01030000234522; -.
DR HOGENOM; CLU_014694_0_1_1; -.
DR InParanoid; Q5DTT8; -.
DR OMA; TKESTHQ; -.
DR OrthoDB; 820525at2759; -.
DR PhylomeDB; Q5DTT8; -.
DR TreeFam; TF335054; -.
DR BioGRID-ORCS; 385377; 2 hits in 70 CRISPR screens.
DR PRO; PR:Q5DTT8; -.
DR Proteomes; UP000000589; Chromosome X.
DR RNAct; Q5DTT8; protein.
DR Bgee; ENSMUSG00000050424; Expressed in cleaving embryo and 22 other tissues.
DR ExpressionAtlas; Q5DTT8; baseline and differential.
DR Genevisible; Q5DTT8; MM.
DR GO; GO:0042802; F:identical protein binding; ISO:MGI.
DR InterPro; IPR026523; PNMA.
DR InterPro; IPR026527; PNMA5.
DR PANTHER; PTHR23095; PTHR23095; 1.
DR PANTHER; PTHR23095:SF4; PTHR23095:SF4; 1.
DR Pfam; PF14893; PNMA; 1.
PE 1: Evidence at protein level;
KW Reference proteome.
FT CHAIN 1..618
FT /note="Paraneoplastic antigen-like protein 5"
FT /id="PRO_0000311218"
FT REGION 390..409
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 451..475
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 519..549
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 524..541
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 618 AA; 69137 MW; AAD4E983ADA29A35 CRC64;
MAVALLDDWC KGMDLDPKKA VLIVGIPVQY TEAAINDALK EGLPPLCAYK VIGRMFRRED
EAKAVLIELP EVVDYTMMPT HIPAEGGAWE VVVKPRSPDD EFMNKLIYFL RDEGRRIVDV
AKALGFSTVP TGKIELKNLD QDKPKGLKSL CNNSTCYKKL KVFSGSPFPG PGEESFETWL
EEVTELMQLW QVSEREKKQC LLESLRGSAL SIMQALWTSN DSLTVEQCLK ALKHIFGNKE
DSKVLQFRFL QSSQKPAEKV SDYLLRLEPL LQKAVQQSPL SAHSADSIRL KHVLSQVSMT
TGLRGKLSLL DQQGCPPTFL ELMKLTRDEE EWESTVVVEE QEQVRRDSSA CEAANEVVTQ
AEDSREVSTQ TTGEEMTSVK RRRLLWRHSA GEEGQRKESG FWAESEPDEQ KPYVRAQESG
NERGAWAVSH PNPKEIEAQD SQEFLPVAGN RDTLTKSWGS PDKGTGDMSV AEGQQGQGKA
PNFLLARNDP NKQEQIPHSS VTTKWQDRGE CQRLKWGASM ITRPQGNPDR SWDTSGSQDG
EDGCSELRMP TGTEAAQGVE EPATGLSWAE DTSAWEQARL GRETVPRRGG RRIQPVFRII
YTALGEPHEG STLESFRE
