ID   PNO1_ASPFU              Reviewed;         252 AA.
AC   Q4WNG7;
DT   20-FEB-2007, integrated into UniProtKB/Swiss-Prot.
DT   05-JUL-2005, sequence version 1.
DT   25-MAY-2022, entry version 102.
DE   RecName: Full=Pre-rRNA-processing protein pno1;
GN   Name=pno1; ORFNames=AFUA_6G06430;
OS   Neosartorya fumigata (strain ATCC MYA-4609 / Af293 / CBS 101355 / FGSC
OS   A1100) (Aspergillus fumigatus).
OC   Eukaryota; Fungi; Dikarya; Ascomycota; Pezizomycotina; Eurotiomycetes;
OC   Eurotiomycetidae; Eurotiales; Aspergillaceae; Aspergillus;
OC   Aspergillus subgen. Fumigati.
OX   NCBI_TaxID=330879;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=ATCC MYA-4609 / Af293 / CBS 101355 / FGSC A1100;
RX   PubMed=16372009; DOI=10.1038/nature04332;
RA   Nierman W.C., Pain A., Anderson M.J., Wortman J.R., Kim H.S., Arroyo J.,
RA   Berriman M., Abe K., Archer D.B., Bermejo C., Bennett J.W., Bowyer P.,
RA   Chen D., Collins M., Coulsen R., Davies R., Dyer P.S., Farman M.L.,
RA   Fedorova N., Fedorova N.D., Feldblyum T.V., Fischer R., Fosker N.,
RA   Fraser A., Garcia J.L., Garcia M.J., Goble A., Goldman G.H., Gomi K.,
RA   Griffith-Jones S., Gwilliam R., Haas B.J., Haas H., Harris D.E.,
RA   Horiuchi H., Huang J., Humphray S., Jimenez J., Keller N., Khouri H.,
RA   Kitamoto K., Kobayashi T., Konzack S., Kulkarni R., Kumagai T., Lafton A.,
RA   Latge J.-P., Li W., Lord A., Lu C., Majoros W.H., May G.S., Miller B.L.,
RA   Mohamoud Y., Molina M., Monod M., Mouyna I., Mulligan S., Murphy L.D.,
RA   O'Neil S., Paulsen I., Penalva M.A., Pertea M., Price C., Pritchard B.L.,
RA   Quail M.A., Rabbinowitsch E., Rawlins N., Rajandream M.A., Reichard U.,
RA   Renauld H., Robson G.D., Rodriguez de Cordoba S., Rodriguez-Pena J.M.,
RA   Ronning C.M., Rutter S., Salzberg S.L., Sanchez M., Sanchez-Ferrero J.C.,
RA   Saunders D., Seeger K., Squares R., Squares S., Takeuchi M., Tekaia F.,
RA   Turner G., Vazquez de Aldana C.R., Weidman J., White O., Woodward J.R.,
RA   Yu J.-H., Fraser C.M., Galagan J.E., Asai K., Machida M., Hall N.,
RA   Barrell B.G., Denning D.W.;
RT   "Genomic sequence of the pathogenic and allergenic filamentous fungus
RT   Aspergillus fumigatus.";
RL   Nature 438:1151-1156(2005).
CC   -!- FUNCTION: Required for small ribosomal subunit (SSU) synthesis. Has a
CC       role in the processing of early nucleolar and late cytoplasmic pre-RNA
CC       species (By similarity). {ECO:0000250}.
CC   -!- SUBUNIT: Component of the small ribosomal subunit, ribosomal RNA
CC       processing complex (SSU RRP complex). {ECO:0000250}.
CC   -!- SUBCELLULAR LOCATION: Cytoplasm {ECO:0000250|UniProtKB:Q99216}.
CC       Nucleus, nucleolus {ECO:0000250|UniProtKB:Q99216}.
CC   -!- SIMILARITY: Belongs to the PNO1 family. {ECO:0000305}.
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DR   EMBL; AAHF01000006; EAL88497.1; -; Genomic_DNA.
DR   RefSeq; XP_750535.1; XM_745442.1.
DR   AlphaFoldDB; Q4WNG7; -.
DR   SMR; Q4WNG7; -.
DR   STRING; 746128.CADAFUBP00007043; -.
DR   EnsemblFungi; EAL88497; EAL88497; AFUA_6G06430.
DR   GeneID; 3508140; -.
DR   KEGG; afm:AFUA_6G06430; -.
DR   eggNOG; KOG3273; Eukaryota.
DR   HOGENOM; CLU_064992_0_2_1; -.
DR   InParanoid; Q4WNG7; -.
DR   OMA; IHIMGSF; -.
DR   OrthoDB; 1269649at2759; -.
DR   Proteomes; UP000002530; Chromosome 6.
DR   GO; GO:0005737; C:cytoplasm; IEA:UniProtKB-SubCell.
DR   GO; GO:0005730; C:nucleolus; IBA:GO_Central.
DR   GO; GO:0003723; F:RNA binding; IEA:UniProtKB-KW.
DR   GO; GO:0051082; F:unfolded protein binding; IEA:EnsemblFungi.
DR   GO; GO:0000447; P:endonucleolytic cleavage in ITS1 to separate SSU-rRNA from 5.8S rRNA and LSU-rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA); IEA:EnsemblFungi.
DR   GO; GO:0000472; P:endonucleolytic cleavage to generate mature 5'-end of SSU-rRNA from (SSU-rRNA, 5.8S rRNA, LSU-rRNA); IEA:EnsemblFungi.
DR   GO; GO:0043248; P:proteasome assembly; IEA:EnsemblFungi.
DR   Gene3D; 3.30.1370.10; -; 1.
DR   InterPro; IPR036612; KH_dom_type_1_sf.
DR   InterPro; IPR039912; PNO1-like.
DR   PANTHER; PTHR12826:SF13; PTHR12826:SF13; 1.
DR   SUPFAM; SSF54791; SSF54791; 1.
PE   3: Inferred from homology;
KW   Cytoplasm; Nucleus; Reference proteome; Ribosome biogenesis; RNA-binding.
FT   CHAIN           1..252
FT                   /note="Pre-rRNA-processing protein pno1"
FT                   /id="PRO_0000278363"
FT   DOMAIN          173..225
FT                   /note="KH"
FT   REGION          1..57
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        18..45
FT                   /note="Polar residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ   SEQUENCE   252 AA;  27812 MW;  AE9CF27588B37AA8 CRC64;
     MPAPTALLRK SDEPLSAEEP SLTFSSDAQA SGQGEAPSPI PTESAQHSDM RIDEESRPVF
     TPITDAGTVL RVETRKVPVP PHRMTPLKAN WPKIYPPLVE HLKLQVRMNI KNRAVELRTS
     KFTTDTGALQ KGEDFVKAFT LGFDVDDAIA LLRLDDLYIR SFEIRDVKAS LNGEHLSRAI
     GRIAGKDGKT KFAIENASRT RVVLQGTKVT ILGRFRDLGI AQEAIVSLIL GSPPGKVYGN
     LRKVASRMKE RF