ID   PNO1_BOVIN              Reviewed;         252 AA.
AC   Q7YRD0; A6QLI9;
DT   09-JAN-2007, integrated into UniProtKB/Swiss-Prot.
DT   01-OCT-2003, sequence version 1.
DT   03-AUG-2022, entry version 100.
DE   RecName: Full=RNA-binding protein PNO1;
GN   Name=PNO1;
OS   Bos taurus (Bovine).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC   Eutheria; Laurasiatheria; Artiodactyla; Ruminantia; Pecora; Bovidae;
OC   Bovinae; Bos.
OX   NCBI_TaxID=9913;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [MRNA].
RX   PubMed=15497447; DOI=10.1080/10425170410001702159;
RA   Zhou G.-J., Zhang Y., Wang J., Guo J.H., Ni J., Zhong Z.-M., Wang L.-Q.,
RA   Dang Y.-J., Dai J.F., Yu L.;
RT   "Cloning and characterization of a novel human RNA binding protein gene
RT   PNO1.";
RL   DNA Seq. 15:219-224(2004).
RN   [2]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
RC   STRAIN=Hereford; TISSUE=Uterus;
RG   NIH - Mammalian Gene Collection (MGC) project;
RL   Submitted (JUN-2007) to the EMBL/GenBank/DDBJ databases.
CC   -!- FUNCTION: Positively regulates dimethylation of two adjacent adenosines
CC       in the loop of a conserved hairpin near the 3'-end of 18S rRNA.
CC       {ECO:0000250|UniProtKB:Q9NRX1}.
CC   -!- SUBCELLULAR LOCATION: Nucleus, nucleolus
CC       {ECO:0000250|UniProtKB:Q9NRX1}.
CC   -!- SIMILARITY: Belongs to the PNO1 family. {ECO:0000305}.
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DR   EMBL; AY336967; AAQ16143.1; -; mRNA.
DR   EMBL; BC147981; AAI47982.1; -; mRNA.
DR   RefSeq; NP_898908.1; NM_183085.1.
DR   AlphaFoldDB; Q7YRD0; -.
DR   SMR; Q7YRD0; -.
DR   STRING; 9913.ENSBTAP00000014019; -.
DR   PaxDb; Q7YRD0; -.
DR   PRIDE; Q7YRD0; -.
DR   Ensembl; ENSBTAT00000014019; ENSBTAP00000014019; ENSBTAG00000010604.
DR   GeneID; 360193; -.
DR   KEGG; bta:360193; -.
DR   CTD; 56902; -.
DR   VEuPathDB; HostDB:ENSBTAG00000010604; -.
DR   VGNC; VGNC:33088; PNO1.
DR   eggNOG; KOG3273; Eukaryota.
DR   GeneTree; ENSGT00390000018052; -.
DR   HOGENOM; CLU_064992_2_0_1; -.
DR   InParanoid; Q7YRD0; -.
DR   OMA; IHIMGSF; -.
DR   OrthoDB; 1269649at2759; -.
DR   TreeFam; TF300114; -.
DR   Proteomes; UP000009136; Chromosome 11.
DR   Bgee; ENSBTAG00000010604; Expressed in oocyte and 108 other tissues.
DR   GO; GO:0005730; C:nucleolus; IBA:GO_Central.
DR   GO; GO:0005654; C:nucleoplasm; IEA:Ensembl.
DR   GO; GO:0003723; F:RNA binding; IEA:UniProtKB-KW.
DR   Gene3D; 3.30.1370.10; -; 2.
DR   InterPro; IPR004087; KH_dom.
DR   InterPro; IPR036612; KH_dom_type_1_sf.
DR   InterPro; IPR039912; PNO1-like.
DR   PANTHER; PTHR12826:SF13; PTHR12826:SF13; 1.
DR   SMART; SM00322; KH; 1.
DR   SUPFAM; SSF54791; SSF54791; 1.
PE   2: Evidence at transcript level;
KW   Acetylation; Nucleus; Reference proteome; RNA-binding.
FT   CHAIN           1..252
FT                   /note="RNA-binding protein PNO1"
FT                   /id="PRO_0000270539"
FT   DOMAIN          173..225
FT                   /note="KH"
FT   REGION          1..66
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   MOD_RES         1
FT                   /note="N-acetylmethionine"
FT                   /evidence="ECO:0000250|UniProtKB:Q9NRX1"
SQ   SEQUENCE   252 AA;  27937 MW;  30D30ED509E6C5BC CRC64;
     MESVMEAQSP LAEDGFSQVT RKGGRRAKKR QAEQPSTQEE GGDATCMDTE EARPAKRPVF
     PPLSGDGFLS GKEETRKIPV PANRYTPLKE NWLKIFTPIV EHLGLQIRFN LKSRNVEIRT
     CKETKDVSAL TKAADFVKAF ILGFQVEDAL ALIRLDDLFL ESFEITDVKP LKGDHLSRAI
     GRIAGKGGKT KFTIENVTRT RIVLADVKVH ILGSFQNIKM ARTAICNLIL GNPPSKVYGN
     IRAVASRAAD RF