ID   PNO1_CHATD              Reviewed;         259 AA.
AC   G0S3T2;
DT   16-MAR-2016, integrated into UniProtKB/Swiss-Prot.
DT   16-MAR-2016, sequence version 2.
DT   25-MAY-2022, entry version 37.
DE   RecName: Full=Pre-rRNA-processing protein PNO1;
GN   Name=PNO1; Synonyms=DIM2; ORFNames=CTHT_0030540;
OS   Chaetomium thermophilum (strain DSM 1495 / CBS 144.50 / IMI 039719).
OC   Eukaryota; Fungi; Dikarya; Ascomycota; Pezizomycotina; Sordariomycetes;
OC   Sordariomycetidae; Sordariales; Chaetomiaceae; Chaetomium.
OX   NCBI_TaxID=759272;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=DSM 1495 / CBS 144.50 / IMI 039719;
RX   PubMed=21784248; DOI=10.1016/j.cell.2011.06.039;
RA   Amlacher S., Sarges P., Flemming D., van Noort V., Kunze R., Devos D.P.,
RA   Arumugam M., Bork P., Hurt E.;
RT   "Insight into structure and assembly of the nuclear pore complex by
RT   utilizing the genome of a eukaryotic thermophile.";
RL   Cell 146:277-289(2011).
CC   -!- FUNCTION: Required for small ribosomal subunit (SSU) synthesis. Has a
CC       role in the processing of early nucleolar and late cytoplasmic pre-RNA
CC       species. {ECO:0000250|UniProtKB:Q99216}.
CC   -!- SUBUNIT: Component of the small ribosomal subunit, ribosomal RNA
CC       processing complex (SSU RRP complex). {ECO:0000250|UniProtKB:Q99216}.
CC   -!- SUBCELLULAR LOCATION: Cytoplasm {ECO:0000250|UniProtKB:Q99216}.
CC       Nucleus, nucleolus {ECO:0000250|UniProtKB:Q99216}.
CC   -!- SIMILARITY: Belongs to the PNO1 family. {ECO:0000305}.
CC   -!- SEQUENCE CAUTION:
CC       Sequence=EGS21208.1; Type=Erroneous gene model prediction; Evidence={ECO:0000305};
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DR   EMBL; GL988041; EGS21208.1; ALT_SEQ; Genomic_DNA.
DR   RefSeq; XP_006693504.1; XM_006693441.1.
DR   PDB; 5OQL; EM; 3.20 A; h=1-259.
DR   PDB; 6RXT; EM; 7.00 A; CQ=1-259.
DR   PDB; 6RXU; EM; 3.50 A; CQ=1-259.
DR   PDB; 6RXV; EM; 4.00 A; CQ=1-259.
DR   PDB; 6RXX; EM; 7.10 A; CQ=1-259.
DR   PDB; 6RXY; EM; 4.70 A; CQ=1-259.
DR   PDB; 6RXZ; EM; 4.40 A; CQ=1-259.
DR   PDBsum; 5OQL; -.
DR   PDBsum; 6RXT; -.
DR   PDBsum; 6RXU; -.
DR   PDBsum; 6RXV; -.
DR   PDBsum; 6RXX; -.
DR   PDBsum; 6RXY; -.
DR   PDBsum; 6RXZ; -.
DR   AlphaFoldDB; G0S3T2; -.
DR   SMR; G0S3T2; -.
DR   IntAct; G0S3T2; 1.
DR   STRING; 759272.G0S3T2; -.
DR   EnsemblFungi; EGS21208; EGS21208; CTHT_0030540.
DR   GeneID; 18257092; -.
DR   KEGG; cthr:CTHT_0030540; -.
DR   eggNOG; KOG3273; Eukaryota.
DR   HOGENOM; CLU_064992_0_2_1; -.
DR   OrthoDB; 1269649at2759; -.
DR   Proteomes; UP000008066; Unassembled WGS sequence.
DR   GO; GO:0005737; C:cytoplasm; IEA:UniProtKB-SubCell.
DR   GO; GO:0005730; C:nucleolus; IEA:UniProtKB-SubCell.
DR   GO; GO:0003723; F:RNA binding; IEA:UniProtKB-KW.
DR   GO; GO:0042254; P:ribosome biogenesis; IEA:UniProtKB-KW.
DR   Gene3D; 3.30.1370.10; -; 1.
DR   InterPro; IPR004087; KH_dom.
DR   InterPro; IPR036612; KH_dom_type_1_sf.
DR   InterPro; IPR039912; PNO1-like.
DR   PANTHER; PTHR12826:SF13; PTHR12826:SF13; 1.
DR   SMART; SM00322; KH; 1.
DR   SUPFAM; SSF54791; SSF54791; 1.
PE   1: Evidence at protein level;
KW   3D-structure; Cytoplasm; Nucleus; Reference proteome; Ribosome biogenesis;
KW   RNA-binding.
FT   CHAIN           1..259
FT                   /note="Pre-rRNA-processing protein PNO1"
FT                   /id="PRO_0000435810"
FT   DOMAIN          180..232
FT                   /note="KH"
FT                   /evidence="ECO:0000305"
FT   REGION          1..25
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   REGION          37..74
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        1..17
FT                   /note="Pro residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        59..74
FT                   /note="Basic and acidic residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ   SEQUENCE   259 AA;  28677 MW;  C3D904A45E65A076 CRC64;
     MPAPTALKQP PPAPEQQAAP AITNENEDEL LIDIQQAAAT LTDPNAAEPP EETMENEMAV
     DEEGRPRFAP GKNIDPIRRI ETRKIPIPPH RMSALKANWT KYPPLVDHCK LQVRMNIKEK
     RVELRSSKYT VSNEALQMGA DFVSAFAMGF DIDDAIALLR LDSLYIQSFD IKDVRQTLGP
     DALSRAIGRI AGKDGKTKFA IENATKTRIV LAGSKVHILG AFENIGMARE SIVSLVLGAQ
     PGKVYNNLRI IASRMKERW