ID   PNO1_KLULA              Reviewed;         274 AA.
AC   Q6CUA5;
DT   20-FEB-2007, integrated into UniProtKB/Swiss-Prot.
DT   16-AUG-2004, sequence version 1.
DT   25-MAY-2022, entry version 95.
DE   RecName: Full=Pre-rRNA-processing protein PNO1;
GN   Name=PNO1; OrderedLocusNames=KLLA0C06446g;
OS   Kluyveromyces lactis (strain ATCC 8585 / CBS 2359 / DSM 70799 / NBRC 1267 /
OS   NRRL Y-1140 / WM37) (Yeast) (Candida sphaerica).
OC   Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes;
OC   Saccharomycetales; Saccharomycetaceae; Kluyveromyces.
OX   NCBI_TaxID=284590;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=ATCC 8585 / CBS 2359 / DSM 70799 / NBRC 1267 / NRRL Y-1140 / WM37;
RX   PubMed=15229592; DOI=10.1038/nature02579;
RA   Dujon B., Sherman D., Fischer G., Durrens P., Casaregola S., Lafontaine I.,
RA   de Montigny J., Marck C., Neuveglise C., Talla E., Goffard N., Frangeul L.,
RA   Aigle M., Anthouard V., Babour A., Barbe V., Barnay S., Blanchin S.,
RA   Beckerich J.-M., Beyne E., Bleykasten C., Boisrame A., Boyer J.,
RA   Cattolico L., Confanioleri F., de Daruvar A., Despons L., Fabre E.,
RA   Fairhead C., Ferry-Dumazet H., Groppi A., Hantraye F., Hennequin C.,
RA   Jauniaux N., Joyet P., Kachouri R., Kerrest A., Koszul R., Lemaire M.,
RA   Lesur I., Ma L., Muller H., Nicaud J.-M., Nikolski M., Oztas S.,
RA   Ozier-Kalogeropoulos O., Pellenz S., Potier S., Richard G.-F.,
RA   Straub M.-L., Suleau A., Swennen D., Tekaia F., Wesolowski-Louvel M.,
RA   Westhof E., Wirth B., Zeniou-Meyer M., Zivanovic Y., Bolotin-Fukuhara M.,
RA   Thierry A., Bouchier C., Caudron B., Scarpelli C., Gaillardin C.,
RA   Weissenbach J., Wincker P., Souciet J.-L.;
RT   "Genome evolution in yeasts.";
RL   Nature 430:35-44(2004).
CC   -!- FUNCTION: Required for small ribosomal subunit (SSU) synthesis. Has a
CC       role in the processing of early nucleolar and late cytoplasmic pre-RNA
CC       species (By similarity). {ECO:0000250}.
CC   -!- SUBUNIT: Component of the small ribosomal subunit, ribosomal RNA
CC       processing complex (SSU RRP complex). {ECO:0000250}.
CC   -!- SUBCELLULAR LOCATION: Cytoplasm {ECO:0000250|UniProtKB:Q99216}.
CC       Nucleus, nucleolus {ECO:0000250|UniProtKB:Q99216}.
CC   -!- SIMILARITY: Belongs to the PNO1 family. {ECO:0000305}.
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DR   EMBL; CR382123; CAH01335.1; -; Genomic_DNA.
DR   RefSeq; XP_452484.1; XM_452484.1.
DR   AlphaFoldDB; Q6CUA5; -.
DR   SMR; Q6CUA5; -.
DR   STRING; 28985.XP_452484.1; -.
DR   EnsemblFungi; CAH01335; CAH01335; KLLA0_C06446g.
DR   GeneID; 2892624; -.
DR   KEGG; kla:KLLA0_C06446g; -.
DR   eggNOG; KOG3273; Eukaryota.
DR   HOGENOM; CLU_064992_0_2_1; -.
DR   InParanoid; Q6CUA5; -.
DR   OMA; IHIMGSF; -.
DR   Proteomes; UP000000598; Chromosome C.
DR   GO; GO:0005737; C:cytoplasm; IEA:UniProtKB-SubCell.
DR   GO; GO:0005730; C:nucleolus; IEA:UniProtKB-SubCell.
DR   GO; GO:0003723; F:RNA binding; IEA:UniProtKB-KW.
DR   GO; GO:0042254; P:ribosome biogenesis; IEA:UniProtKB-KW.
DR   Gene3D; 3.30.1370.10; -; 1.
DR   InterPro; IPR036612; KH_dom_type_1_sf.
DR   InterPro; IPR039912; PNO1-like.
DR   PANTHER; PTHR12826:SF13; PTHR12826:SF13; 1.
DR   SUPFAM; SSF54791; SSF54791; 1.
PE   3: Inferred from homology;
KW   Cytoplasm; Nucleus; Reference proteome; Ribosome biogenesis; RNA-binding.
FT   CHAIN           1..274
FT                   /note="Pre-rRNA-processing protein PNO1"
FT                   /id="PRO_0000278372"
FT   DOMAIN          195..247
FT                   /note="KH"
FT   REGION          1..39
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        14..28
FT                   /note="Polar residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ   SEQUENCE   274 AA;  30241 MW;  CF83756CBCCE7691 CRC64;
     MVAPTALKKS DVSEGTVPVT TTSRIVGVDN TEKIDEDDDD ADVLIDQDGD AMLVDEENNE
     ESNKKKEDAG VVLDAEGKPR FTSAASSAQT KVKLESRKVS VPPHRMTPLK NNWSKIYPPL
     VDHLKLQVRM NLKTKSVELR THPKHTTDPG ALQKGADFIK AFTLGFDLDD SIALLRLDDL
     YIETFEIKDV KTLQGDHLSR AIGRIAGKDG KTKFAIENAT RTRIVLADSK IHILGGFTHI
     RMARESVVSL ILGSPPGKVY GNLRTVASRL KERY