ID   PNO1_RAT                Reviewed;         248 AA.
AC   Q6VBQ8;
DT   09-JAN-2007, integrated into UniProtKB/Swiss-Prot.
DT   05-JUL-2004, sequence version 1.
DT   25-MAY-2022, entry version 98.
DE   RecName: Full=RNA-binding protein PNO1;
GN   Name=Pno1;
OS   Rattus norvegicus (Rat).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC   Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae;
OC   Murinae; Rattus.
OX   NCBI_TaxID=10116;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [MRNA].
RC   STRAIN=Sprague-Dawley;
RX   PubMed=15497447; DOI=10.1080/10425170410001702159;
RA   Zhou G.-J., Zhang Y., Wang J., Guo J.H., Ni J., Zhong Z.-M., Wang L.-Q.,
RA   Dang Y.-J., Dai J.F., Yu L.;
RT   "Cloning and characterization of a novel human RNA binding protein gene
RT   PNO1.";
RL   DNA Seq. 15:219-224(2004).
RN   [2]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
RC   TISSUE=Liver;
RX   PubMed=15489334; DOI=10.1101/gr.2596504;
RG   The MGC Project Team;
RT   "The status, quality, and expansion of the NIH full-length cDNA project:
RT   the Mammalian Gene Collection (MGC).";
RL   Genome Res. 14:2121-2127(2004).
CC   -!- FUNCTION: Positively regulates dimethylation of two adjacent adenosines
CC       in the loop of a conserved hairpin near the 3'-end of 18S rRNA.
CC       {ECO:0000250|UniProtKB:Q9NRX1}.
CC   -!- SUBCELLULAR LOCATION: Nucleus, nucleolus
CC       {ECO:0000250|UniProtKB:Q9NRX1}.
CC   -!- SIMILARITY: Belongs to the PNO1 family. {ECO:0000305}.
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DR   EMBL; AY344057; AAQ24834.1; -; mRNA.
DR   EMBL; BC088091; AAH88091.1; -; mRNA.
DR   RefSeq; NP_954514.2; NM_199083.2.
DR   AlphaFoldDB; Q6VBQ8; -.
DR   SMR; Q6VBQ8; -.
DR   STRING; 10116.ENSRNOP00000007824; -.
DR   jPOST; Q6VBQ8; -.
DR   PaxDb; Q6VBQ8; -.
DR   PRIDE; Q6VBQ8; -.
DR   GeneID; 289809; -.
DR   KEGG; rno:289809; -.
DR   UCSC; RGD:727882; rat.
DR   CTD; 56902; -.
DR   RGD; 727882; Pno1.
DR   eggNOG; KOG3273; Eukaryota.
DR   InParanoid; Q6VBQ8; -.
DR   OrthoDB; 1269649at2759; -.
DR   PhylomeDB; Q6VBQ8; -.
DR   TreeFam; TF300114; -.
DR   Reactome; R-RNO-6791226; Major pathway of rRNA processing in the nucleolus and cytosol.
DR   PRO; PR:Q6VBQ8; -.
DR   Proteomes; UP000002494; Unplaced.
DR   GO; GO:0005730; C:nucleolus; ISS:UniProtKB.
DR   GO; GO:0003723; F:RNA binding; IEA:UniProtKB-KW.
DR   Gene3D; 3.30.1370.10; -; 2.
DR   InterPro; IPR004087; KH_dom.
DR   InterPro; IPR036612; KH_dom_type_1_sf.
DR   InterPro; IPR039912; PNO1-like.
DR   PANTHER; PTHR12826:SF13; PTHR12826:SF13; 1.
DR   SMART; SM00322; KH; 1.
DR   SUPFAM; SSF54791; SSF54791; 1.
PE   2: Evidence at transcript level;
KW   Nucleus; Reference proteome; RNA-binding.
FT   CHAIN           1..248
FT                   /note="RNA-binding protein PNO1"
FT                   /id="PRO_0000270542"
FT   DOMAIN          169..221
FT                   /note="KH"
FT   REGION          1..63
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ   SEQUENCE   248 AA;  27472 MW;  1F215F98C0580C31 CRC64;
     METQNTGTED GFTPVTHRGG RRAKKRQAEQ SSAAGQDGDA GRMDTEEARP AKRPVFPPLS
     GDQLLTGKEE TRKIPVPANR YTPLKENWMK IFTPIVEHLG LQIRFNLKSR NVEIRTCKDT
     KDVSALTKAA DFVKAFVLGF QVEDALALIR LDDLFLESFE ITDVKPLKGD HLSRAIGRIA
     GKGGKTKFTI ENVTRTRIVL ADVKVHILGS FQNIKMARTA ICNLILGNPP SKVYGNIRAV
     ASRSADRF