ID   PNO1_XENLA              Reviewed;         236 AA.
AC   Q8AVH4;
DT   09-JAN-2007, integrated into UniProtKB/Swiss-Prot.
DT   01-MAR-2003, sequence version 1.
DT   03-AUG-2022, entry version 78.
DE   RecName: Full=RNA-binding protein PNO1;
GN   Name=pno1;
OS   Xenopus laevis (African clawed frog).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Amphibia;
OC   Batrachia; Anura; Pipoidea; Pipidae; Xenopodinae; Xenopus; Xenopus.
OX   NCBI_TaxID=8355;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [MRNA].
RX   PubMed=15497447; DOI=10.1080/10425170410001702159;
RA   Zhou G.-J., Zhang Y., Wang J., Guo J.H., Ni J., Zhong Z.-M., Wang L.-Q.,
RA   Dang Y.-J., Dai J.F., Yu L.;
RT   "Cloning and characterization of a novel human RNA binding protein gene
RT   PNO1.";
RL   DNA Seq. 15:219-224(2004).
RN   [2]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
RC   TISSUE=Embryo;
RG   NIH - Xenopus Gene Collection (XGC) project;
RL   Submitted (JAN-2003) to the EMBL/GenBank/DDBJ databases.
CC   -!- FUNCTION: Positively regulates dimethylation of two adjacent adenosines
CC       in the loop of a conserved hairpin near the 3'-end of 18S rRNA.
CC       {ECO:0000250|UniProtKB:Q9NRX1}.
CC   -!- SUBCELLULAR LOCATION: Nucleus, nucleolus
CC       {ECO:0000250|UniProtKB:Q9NRX1}.
CC   -!- SIMILARITY: Belongs to the PNO1 family. {ECO:0000305}.
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DR   EMBL; BC042279; AAH42279.1; -; mRNA.
DR   EMBL; AY341885; AAQ24169.1; -; mRNA.
DR   RefSeq; NP_001079442.1; NM_001085973.2.
DR   AlphaFoldDB; Q8AVH4; -.
DR   SMR; Q8AVH4; -.
DR   DNASU; 379129; -.
DR   GeneID; 379129; -.
DR   KEGG; xla:379129; -.
DR   CTD; 379129; -.
DR   Xenbase; XB-GENE-866051; pno1.L.
DR   OMA; IHIMGSF; -.
DR   OrthoDB; 1269649at2759; -.
DR   Proteomes; UP000186698; Chromosome 5L.
DR   Bgee; 379129; Expressed in pancreas and 19 other tissues.
DR   GO; GO:0005730; C:nucleolus; ISS:UniProtKB.
DR   GO; GO:0003723; F:RNA binding; IEA:UniProtKB-KW.
DR   Gene3D; 3.30.1370.10; -; 2.
DR   InterPro; IPR041174; KH_8.
DR   InterPro; IPR004087; KH_dom.
DR   InterPro; IPR004088; KH_dom_type_1.
DR   InterPro; IPR036612; KH_dom_type_1_sf.
DR   InterPro; IPR039912; PNO1-like.
DR   PANTHER; PTHR12826:SF13; PTHR12826:SF13; 1.
DR   Pfam; PF00013; KH_1; 1.
DR   Pfam; PF17903; KH_8; 1.
DR   SMART; SM00322; KH; 1.
DR   SUPFAM; SSF54791; SSF54791; 1.
PE   2: Evidence at transcript level;
KW   Nucleus; Reference proteome; RNA-binding.
FT   CHAIN           1..236
FT                   /note="RNA-binding protein PNO1"
FT                   /id="PRO_0000270546"
FT   DOMAIN          152..209
FT                   /note="KH"
FT   REGION          1..65
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        17..37
FT                   /note="Basic and acidic residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        50..64
FT                   /note="Basic and acidic residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ   SEQUENCE   236 AA;  26366 MW;  30F5EC6677C12143 CRC64;
     MEIESAATSG ESFTSVTSKK SRKRRAAEER PMDMGEQPSK RPDFPPISGD KLMGDKDEMR
     KIPVPSHRYT PLKENWMKIF TPIVEHLQLQ VRFNLKSRNV EIKTCKETTD VGALTKAADF
     VRAFILGFQV EDALALVRLD DLFLESFEVT DVKPLKGDHL SRAIGRIAGK GGKTKFTIEN
     VTKTRIVLAD SKIHIMGSFQ NIKMARTAIC NLILGSPPSK VYGNIRAVAS RAADRF