ID   PNO1_XENTR              Reviewed;         236 AA.
AC   Q6DDB9;
DT   09-JAN-2007, integrated into UniProtKB/Swiss-Prot.
DT   16-AUG-2004, sequence version 1.
DT   03-AUG-2022, entry version 87.
DE   RecName: Full=RNA-binding protein PNO1;
GN   Name=pno1; ORFNames=TTpA007f20.1;
OS   Xenopus tropicalis (Western clawed frog) (Silurana tropicalis).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Amphibia;
OC   Batrachia; Anura; Pipoidea; Pipidae; Xenopodinae; Xenopus; Silurana.
OX   NCBI_TaxID=8364;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
RC   TISSUE=Tadpole;
RG   Sanger Xenopus tropicalis EST/cDNA project;
RL   Submitted (OCT-2006) to the EMBL/GenBank/DDBJ databases.
RN   [2]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
RC   TISSUE=Embryo;
RG   NIH - Xenopus Gene Collection (XGC) project;
RL   Submitted (JUL-2004) to the EMBL/GenBank/DDBJ databases.
CC   -!- FUNCTION: Positively regulates dimethylation of two adjacent adenosines
CC       in the loop of a conserved hairpin near the 3'-end of 18S rRNA.
CC       {ECO:0000250|UniProtKB:Q9NRX1}.
CC   -!- SUBCELLULAR LOCATION: Nucleus, nucleolus
CC       {ECO:0000250|UniProtKB:Q9NRX1}.
CC   -!- SIMILARITY: Belongs to the PNO1 family. {ECO:0000305}.
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DR   EMBL; CR848253; CAJ83155.1; -; mRNA.
DR   EMBL; BC077670; AAH77670.1; -; mRNA.
DR   RefSeq; NP_001005132.1; NM_001005132.2.
DR   AlphaFoldDB; Q6DDB9; -.
DR   SMR; Q6DDB9; -.
DR   PaxDb; Q6DDB9; -.
DR   DNASU; 448715; -.
DR   GeneID; 448715; -.
DR   KEGG; xtr:448715; -.
DR   CTD; 56902; -.
DR   Xenbase; XB-GENE-491293; pno1.
DR   eggNOG; KOG3273; Eukaryota.
DR   HOGENOM; CLU_064992_2_0_1; -.
DR   InParanoid; Q6DDB9; -.
DR   OrthoDB; 1269649at2759; -.
DR   PhylomeDB; Q6DDB9; -.
DR   Proteomes; UP000008143; Chromosome 5.
DR   Proteomes; UP000790000; Unplaced.
DR   Bgee; ENSXETG00000017349; Expressed in heart and 21 other tissues.
DR   GO; GO:0005730; C:nucleolus; ISS:UniProtKB.
DR   GO; GO:0003723; F:RNA binding; IEA:UniProtKB-KW.
DR   Gene3D; 3.30.1370.10; -; 2.
DR   InterPro; IPR041174; KH_8.
DR   InterPro; IPR004087; KH_dom.
DR   InterPro; IPR036612; KH_dom_type_1_sf.
DR   InterPro; IPR039912; PNO1-like.
DR   PANTHER; PTHR12826:SF13; PTHR12826:SF13; 1.
DR   Pfam; PF17903; KH_8; 1.
DR   SMART; SM00322; KH; 1.
DR   SUPFAM; SSF54791; SSF54791; 1.
PE   2: Evidence at transcript level;
KW   Nucleus; Reference proteome; RNA-binding.
FT   CHAIN           1..236
FT                   /note="RNA-binding protein PNO1"
FT                   /id="PRO_0000270547"
FT   DOMAIN          152..209
FT                   /note="KH"
FT   REGION          1..59
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        1..16
FT                   /note="Polar residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        17..37
FT                   /note="Basic and acidic residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ   SEQUENCE   236 AA;  26347 MW;  99C9A521A01D5DE7 CRC64;
     METESAAASG ESFTSVTSKK TRKRRAAEER PMDTGEQPSK RPDFPPISGD KLMGDKDEMR
     KVPVPSHRYT PLKENWMKIF TPIVEHLQLQ VRFNLKTRNV EIKTCKETTD VGALTKATDF
     VRAFILGFQV EDALALVRLD DLFLESFEVT DVKPLKGDHL SRAIGRIAGK GGKTKFTIEN
     VTRTRIVLAD SKIHILGSFQ NIKMARTAIC NLILGSPPSK VYGNIRAVAS RAADRF