PNOC_BOVIN
ID PNOC_BOVIN Reviewed; 176 AA.
AC O62647;
DT 15-DEC-1998, integrated into UniProtKB/Swiss-Prot.
DT 01-AUG-1998, sequence version 1.
DT 03-AUG-2022, entry version 112.
DE RecName: Full=Prepronociceptin;
DE Contains:
DE RecName: Full=Nocistatin;
DE Contains:
DE RecName: Full=Nociceptin;
DE AltName: Full=Orphanin FQ;
DE AltName: Full=PPNOC;
DE Contains:
DE RecName: Full=Orphanin FQ2;
DE Flags: Precursor;
GN Name=PNOC;
OS Bos taurus (Bovine).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Laurasiatheria; Artiodactyla; Ruminantia; Pecora; Bovidae;
OC Bovinae; Bos.
OX NCBI_TaxID=9913;
RN [1]
RP NUCLEOTIDE SEQUENCE [MRNA], AND FUNCTION OF NOCISTATIN.
RX PubMed=9521323; DOI=10.1038/32660;
RA Okuda-Ashitaka E., Minami T., Tachibana S., Yoshihara Y., Nishiuchi Y.,
RA Kimura T., Ito S.;
RT "Nocistatin, a peptide that blocks nociceptin action in pain
RT transmission.";
RL Nature 392:286-289(1998).
CC -!- FUNCTION: [Nociceptin]: Ligand of the opioid receptor-like receptor
CC OPRL1. It may act as a transmitter in the brain by modulating
CC nociceptive and locomotor behavior. May be involved in neuronal
CC differentiation and development. {ECO:0000250|UniProtKB:P55791}.
CC -!- FUNCTION: [Nocistatin]: Blocks nociceptin action in pain transmission
CC by inhibiting nociceptin-induced hyperalgesia and allodynia.
CC {ECO:0000269|PubMed:9521323}.
CC -!- FUNCTION: [Orphanin FQ2]: Has potent analgesic activity.
CC {ECO:0000250|UniProtKB:Q64387}.
CC -!- SUBCELLULAR LOCATION: Secreted.
CC -!- PTM: Specific enzymatic cleavages at paired basic residues probably
CC yield other active peptides besides nociceptin.
CC -!- PTM: The N-terminal domain contains 6 conserved cysteines thought to be
CC involved in disulfide bonding and/or processing.
CC -!- SIMILARITY: Belongs to the opioid neuropeptide precursor family.
CC {ECO:0000305}.
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DR EMBL; AB005251; BAA25419.1; -; mRNA.
DR RefSeq; NP_776575.1; NM_174150.2.
DR RefSeq; XP_015327885.1; XM_015472399.1.
DR AlphaFoldDB; O62647; -.
DR STRING; 9913.ENSBTAP00000000695; -.
DR PaxDb; O62647; -.
DR PRIDE; O62647; -.
DR Ensembl; ENSBTAT00000000695; ENSBTAP00000000695; ENSBTAG00000000534.
DR GeneID; 281414; -.
DR KEGG; bta:281414; -.
DR CTD; 5368; -.
DR VEuPathDB; HostDB:ENSBTAG00000000534; -.
DR VGNC; VGNC:33089; PNOC.
DR eggNOG; ENOG502S0DD; Eukaryota.
DR GeneTree; ENSGT00950000183149; -.
DR HOGENOM; CLU_143892_0_0_1; -.
DR InParanoid; O62647; -.
DR OMA; WTPCTKI; -.
DR OrthoDB; 1486887at2759; -.
DR TreeFam; TF332620; -.
DR Reactome; R-BTA-375276; Peptide ligand-binding receptors.
DR Reactome; R-BTA-418594; G alpha (i) signalling events.
DR Proteomes; UP000009136; Chromosome 8.
DR Bgee; ENSBTAG00000000534; Expressed in oocyte and 23 other tissues.
DR GO; GO:0043679; C:axon terminus; IBA:GO_Central.
DR GO; GO:0030425; C:dendrite; IBA:GO_Central.
DR GO; GO:0005576; C:extracellular region; IEA:UniProtKB-SubCell.
DR GO; GO:0043025; C:neuronal cell body; IBA:GO_Central.
DR GO; GO:0005886; C:plasma membrane; IBA:GO_Central.
DR GO; GO:0001515; F:opioid peptide activity; IEA:UniProtKB-KW.
DR GO; GO:0031628; F:opioid receptor binding; IBA:GO_Central.
DR GO; GO:0007268; P:chemical synaptic transmission; IBA:GO_Central.
DR GO; GO:0007218; P:neuropeptide signaling pathway; IBA:GO_Central.
DR GO; GO:0007600; P:sensory perception; IBA:GO_Central.
DR InterPro; IPR002367; Nociceptin.
DR InterPro; IPR006024; Opioid_neupept.
DR PANTHER; PTHR11438; PTHR11438; 1.
DR Pfam; PF01160; Opiods_neuropep; 1.
DR PRINTS; PR01028; OPIOIDPRCRSR.
DR PRINTS; PR01031; ORPHNNPRCRSR.
DR PROSITE; PS01252; OPIOIDS_PRECURSOR; 1.
PE 2: Evidence at transcript level;
KW Cleavage on pair of basic residues; Disulfide bond; Neuropeptide;
KW Neurotransmitter; Opioid peptide; Reference proteome; Secreted; Signal.
FT SIGNAL 1..19
FT /evidence="ECO:0000255"
FT PROPEP 20..95
FT /id="PRO_0000008320"
FT PEPTIDE 98..127
FT /note="Nocistatin"
FT /evidence="ECO:0000305"
FT /id="PRO_0000008321"
FT PEPTIDE 130..146
FT /note="Nociceptin"
FT /evidence="ECO:0000250|UniProtKB:P55791"
FT /id="PRO_0000008322"
FT PEPTIDE 149..165
FT /note="Orphanin FQ2"
FT /evidence="ECO:0000305"
FT /id="PRO_0000008323"
FT PROPEP 169..176
FT /id="PRO_0000008324"
SQ SEQUENCE 176 AA; 20256 MW; 0245B61BD81ECA26 CRC64;
MKILFCDLLL LSLFSSVSSS CQKDCLVCRE KLRPTLDSFS LEMCILECEE KAFTSPLWTP
CTKVMARGSW QLSPADPDHV AAALDQPRAS EMQHLKRMPR VRSLFQRQKR TEPGLEEVGE
IEQKQLQKRF GGFTGARKSA RKLANQKRFS EFMRQYLVLS MQSSQRRRTL HQNGNA