ID   PNOC_PIG                Reviewed;          17 AA.
AC   P55791;
DT   01-NOV-1997, integrated into UniProtKB/Swiss-Prot.
DT   01-NOV-1997, sequence version 1.
DT   25-MAY-2022, entry version 56.
DE   RecName: Full=Nociceptin;
DE   AltName: Full=Orphanin FQ {ECO:0000303|PubMed:7481766};
GN   Name=PNOC;
OS   Sus scrofa (Pig).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC   Eutheria; Laurasiatheria; Artiodactyla; Suina; Suidae; Sus.
OX   NCBI_TaxID=9823;
RN   [1]
RP   PROTEIN SEQUENCE, AND FUNCTION.
RC   TISSUE=Hypothalamus;
RX   PubMed=7481766; DOI=10.1126/science.270.5237.792;
RA   Reinscheid R.K., Nothacker H.-P., Bourson A., Ardati A., Henningsen R.A.,
RA   Bunzow J.R., Grandy D.K., Langen H., Monsma F.J. Jr., Civelli O.;
RT   "Orphanin FQ: a neuropeptide that activates an opioidlike G protein-coupled
RT   receptor.";
RL   Science 270:792-794(1995).
CC   -!- FUNCTION: Ligand of the opioid receptor-like receptor OPRL1. It may act
CC       as a transmitter in the brain by modulating nociceptive and locomotor
CC       behavior. May be involved in neuronal differentiation and development.
CC       When administered intracerebroventricularly into mice, this peptide
CC       induces hyperalgesia and decreases locomotor activity.
CC       {ECO:0000269|PubMed:7481766}.
CC   -!- SUBCELLULAR LOCATION: Secreted.
CC   -!- SIMILARITY: Belongs to the opioid neuropeptide precursor family.
CC       {ECO:0000305}.
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DR   AlphaFoldDB; P55791; -.
DR   eggNOG; ENOG502S0DD; Eukaryota.
DR   Proteomes; UP000008227; Unplaced.
DR   Proteomes; UP000314985; Unplaced.
DR   GO; GO:0005576; C:extracellular region; IEA:UniProtKB-SubCell.
DR   GO; GO:0045202; C:synapse; IEA:GOC.
DR   GO; GO:0001515; F:opioid peptide activity; IEA:UniProtKB-KW.
DR   GO; GO:0007268; P:chemical synaptic transmission; IEA:UniProtKB-KW.
DR   GO; GO:0007218; P:neuropeptide signaling pathway; IEA:UniProtKB-KW.
PE   1: Evidence at protein level;
KW   Direct protein sequencing; Neuropeptide; Neurotransmitter; Opioid peptide;
KW   Reference proteome; Secreted.
FT   PEPTIDE         1..17
FT                   /note="Nociceptin"
FT                   /evidence="ECO:0000269|PubMed:7481766"
FT                   /id="PRO_0000043646"
SQ   SEQUENCE   17 AA;  1809 MW;  3F63A785F8768409 CRC64;
     FGGFTGARKS ARKLANQ