AT1B2_RABIT
ID AT1B2_RABIT Reviewed; 290 AA.
AC Q8WMG3;
DT 12-DEC-2006, integrated into UniProtKB/Swiss-Prot.
DT 01-MAR-2002, sequence version 1.
DT 03-AUG-2022, entry version 99.
DE RecName: Full=Sodium/potassium-transporting ATPase subunit beta-2;
DE AltName: Full=Sodium/potassium-dependent ATPase subunit beta-2;
GN Name=ATP1B2;
OS Oryctolagus cuniculus (Rabbit).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Euarchontoglires; Glires; Lagomorpha; Leporidae; Oryctolagus.
OX NCBI_TaxID=9986;
RN [1]
RP NUCLEOTIDE SEQUENCE [MRNA].
RC TISSUE=Renal medulla;
RA Gumz M.L., Cain B.D.;
RT "Identification of the rabbit Na+K+ ATPase beta 2 subunit.";
RL Submitted (DEC-2001) to the EMBL/GenBank/DDBJ databases.
CC -!- FUNCTION: This is the non-catalytic component of the active enzyme,
CC which catalyzes the hydrolysis of ATP coupled with the exchange of
CC Na(+) and K(+) ions across the plasma membrane. The exact function of
CC the beta-2 subunit is not known (By similarity). {ECO:0000250}.
CC -!- FUNCTION: Mediates cell adhesion of neurons and astrocytes, and
CC promotes neurite outgrowth. {ECO:0000250}.
CC -!- SUBUNIT: The sodium/potassium-transporting ATPase is composed of a
CC catalytic alpha subunit, an auxiliary non-catalytic beta subunit and an
CC additional regulatory subunit. Interacts with BSG (By similarity).
CC {ECO:0000250|UniProtKB:P14231, ECO:0000305}.
CC -!- SUBCELLULAR LOCATION: Cell membrane {ECO:0000250}; Single-pass type II
CC membrane protein {ECO:0000250}.
CC -!- DOMAIN: The C-terminal lobe folds into an immunoglobulin-like domain
CC and mediates cell adhesion properties. {ECO:0000250}.
CC -!- SIMILARITY: Belongs to the X(+)/potassium ATPases subunit beta family.
CC {ECO:0000305}.
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DR EMBL; AY069937; AAL55426.1; -; mRNA.
DR RefSeq; NP_001076249.1; NM_001082780.1.
DR AlphaFoldDB; Q8WMG3; -.
DR SMR; Q8WMG3; -.
DR STRING; 9986.ENSOCUP00000002598; -.
DR Ensembl; ENSOCUT00000002988; ENSOCUP00000002598; ENSOCUG00000002988.
DR GeneID; 100009577; -.
DR KEGG; ocu:100009577; -.
DR CTD; 482; -.
DR eggNOG; KOG3927; Eukaryota.
DR GeneTree; ENSGT01030000234579; -.
DR HOGENOM; CLU_057702_1_1_1; -.
DR InParanoid; Q8WMG3; -.
DR OMA; VCRPGHY; -.
DR OrthoDB; 998086at2759; -.
DR TreeFam; TF314618; -.
DR Proteomes; UP000001811; Chromosome 19.
DR Bgee; ENSOCUG00000002988; Expressed in frontal cortex and 17 other tissues.
DR GO; GO:0016324; C:apical plasma membrane; IEA:Ensembl.
DR GO; GO:0097450; C:astrocyte end-foot; IEA:Ensembl.
DR GO; GO:0044298; C:cell body membrane; IEA:Ensembl.
DR GO; GO:0031253; C:cell projection membrane; IEA:Ensembl.
DR GO; GO:0005737; C:cytoplasm; IEA:Ensembl.
DR GO; GO:0009897; C:external side of plasma membrane; IEA:Ensembl.
DR GO; GO:0016328; C:lateral plasma membrane; IEA:Ensembl.
DR GO; GO:0098984; C:neuron to neuron synapse; IEA:Ensembl.
DR GO; GO:0001917; C:photoreceptor inner segment; IEA:Ensembl.
DR GO; GO:0005890; C:sodium:potassium-exchanging ATPase complex; IEA:Ensembl.
DR GO; GO:0001671; F:ATPase activator activity; IEA:Ensembl.
DR GO; GO:0051117; F:ATPase binding; IEA:Ensembl.
DR GO; GO:0030674; F:protein-macromolecule adaptor activity; IEA:Ensembl.
DR GO; GO:0031589; P:cell-substrate adhesion; IEA:Ensembl.
DR GO; GO:0030007; P:cellular potassium ion homeostasis; IEA:Ensembl.
DR GO; GO:0006883; P:cellular sodium ion homeostasis; IEA:Ensembl.
DR GO; GO:0021670; P:lateral ventricle development; IEA:Ensembl.
DR GO; GO:0086009; P:membrane repolarization; IEA:Ensembl.
DR GO; GO:0061744; P:motor behavior; IEA:Ensembl.
DR GO; GO:1903976; P:negative regulation of glial cell migration; IEA:Ensembl.
DR GO; GO:0021944; P:neuronal-glial interaction involved in hindbrain glial-mediated radial cell migration; IEA:Ensembl.
DR GO; GO:0045494; P:photoreceptor cell maintenance; IEA:Ensembl.
DR GO; GO:0120036; P:plasma membrane bounded cell projection organization; IEA:Ensembl.
DR GO; GO:0032781; P:positive regulation of ATP-dependent activity; IEA:Ensembl.
DR GO; GO:0010976; P:positive regulation of neuron projection development; IEA:Ensembl.
DR GO; GO:1903288; P:positive regulation of potassium ion import across plasma membrane; IEA:Ensembl.
DR GO; GO:1901018; P:positive regulation of potassium ion transmembrane transporter activity; IEA:Ensembl.
DR GO; GO:1903278; P:positive regulation of sodium ion export across plasma membrane; IEA:Ensembl.
DR GO; GO:1990573; P:potassium ion import across plasma membrane; IEA:Ensembl.
DR GO; GO:0050821; P:protein stabilization; IEA:Ensembl.
DR GO; GO:0036376; P:sodium ion export across plasma membrane; IEA:Ensembl.
DR GO; GO:0021678; P:third ventricle development; IEA:Ensembl.
DR Gene3D; 2.60.40.1660; -; 1.
DR InterPro; IPR000402; Na/K_ATPase_sub_beta.
DR InterPro; IPR038702; Na/K_ATPase_sub_beta_sf.
DR PANTHER; PTHR11523; PTHR11523; 1.
DR Pfam; PF00287; Na_K-ATPase; 1.
DR TIGRFAMs; TIGR01107; Na_K_ATPase_bet; 1.
DR PROSITE; PS00390; ATPASE_NA_K_BETA_1; 1.
DR PROSITE; PS00391; ATPASE_NA_K_BETA_2; 1.
PE 2: Evidence at transcript level;
KW Cell adhesion; Cell membrane; Disulfide bond; Glycoprotein; Ion transport;
KW Membrane; Potassium; Potassium transport; Reference proteome;
KW Signal-anchor; Sodium; Sodium transport; Sodium/potassium transport;
KW Transmembrane; Transmembrane helix; Transport.
FT CHAIN 1..290
FT /note="Sodium/potassium-transporting ATPase subunit beta-2"
FT /id="PRO_0000265960"
FT TOPO_DOM 1..39
FT /note="Cytoplasmic"
FT /evidence="ECO:0000255"
FT TRANSMEM 40..67
FT /note="Helical; Signal-anchor for type II membrane protein"
FT /evidence="ECO:0000255"
FT TOPO_DOM 68..290
FT /note="Extracellular"
FT /evidence="ECO:0000255"
FT REGION 193..290
FT /note="immunoglobulin-like"
FT /evidence="ECO:0000250"
FT CARBOHYD 96
FT /note="N-linked (GlcNAc...) asparagine"
FT /evidence="ECO:0000255"
FT CARBOHYD 118
FT /note="N-linked (GlcNAc...) asparagine"
FT /evidence="ECO:0000255"
FT CARBOHYD 153
FT /note="N-linked (GlcNAc...) asparagine"
FT /evidence="ECO:0000255"
FT CARBOHYD 159
FT /note="N-linked (GlcNAc...) asparagine"
FT /evidence="ECO:0000255"
FT CARBOHYD 193
FT /note="N-linked (GlcNAc...) asparagine"
FT /evidence="ECO:0000255"
FT CARBOHYD 197
FT /note="N-linked (GlcNAc...) asparagine"
FT /evidence="ECO:0000255"
FT CARBOHYD 238
FT /note="N-linked (GlcNAc...) asparagine"
FT /evidence="ECO:0000255"
FT DISULFID 129..150
FT /evidence="ECO:0000250"
FT DISULFID 160..177
FT /evidence="ECO:0000250"
FT DISULFID 200..261
FT /evidence="ECO:0000250"
SQ SEQUENCE 290 AA; 33391 MW; 2D1F477D307D5F51 CRC64;
MVIQKEKKSC GQVVEEWKEF VWNPRTHQFM GRTGTSWAFI LLFYLVFYGF LTAMFTLTMW
VMLQTVSEHT PKYQDRLATP GLMIRPKTEN LDVIVNVSDT ESWDQHVQKL NKFLEPYNDS
IQAQKNDVCR PGRYYEQPDN GVLNYPKRAC QFNRTQLGNC SGIGDPTHYG YSTGQPCVFI
KMNRVINFYA GANQSMNVTC AGKRDEDAEN LGNFVMFPAN GNIDLMYFPY YGKKFHVNYT
QPLVAVKFLN VTPNVEVNVE CRINAANIAT DDERDKFAGR VAFKLRINKT
