ID   AT1B3_CAEBR             Reviewed;         326 AA.
AC   A8X4W9;
DT   15-JUN-2010, integrated into UniProtKB/Swiss-Prot.
DT   15-JUN-2010, sequence version 3.
DT   25-MAY-2022, entry version 59.
DE   RecName: Full=Probable sodium/potassium-transporting ATPase subunit beta-3 {ECO:0000250|UniProtKB:Q9XUY5};
DE   AltName: Full=Sodium/potassium-dependent ATPase subunit beta-3 {ECO:0000250|UniProtKB:Q9XUY5};
GN   Name=nkb-3; ORFNames=CBG07375;
OS   Caenorhabditis briggsae.
OC   Eukaryota; Metazoa; Ecdysozoa; Nematoda; Chromadorea; Rhabditida;
OC   Rhabditina; Rhabditomorpha; Rhabditoidea; Rhabditidae; Peloderinae;
OC   Caenorhabditis.
OX   NCBI_TaxID=6238;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=AF16;
RX   PubMed=14624247; DOI=10.1371/journal.pbio.0000045;
RA   Stein L.D., Bao Z., Blasiar D., Blumenthal T., Brent M.R., Chen N.,
RA   Chinwalla A., Clarke L., Clee C., Coghlan A., Coulson A., D'Eustachio P.,
RA   Fitch D.H.A., Fulton L.A., Fulton R.E., Griffiths-Jones S., Harris T.W.,
RA   Hillier L.W., Kamath R., Kuwabara P.E., Mardis E.R., Marra M.A.,
RA   Miner T.L., Minx P., Mullikin J.C., Plumb R.W., Rogers J., Schein J.E.,
RA   Sohrmann M., Spieth J., Stajich J.E., Wei C., Willey D., Wilson R.K.,
RA   Durbin R.M., Waterston R.H.;
RT   "The genome sequence of Caenorhabditis briggsae: a platform for comparative
RT   genomics.";
RL   PLoS Biol. 1:166-192(2003).
CC   -!- FUNCTION: This is the non-catalytic component of the active enzyme,
CC       which catalyzes the hydrolysis of ATP coupled with the exchange of
CC       Na(+) and K(+) ions across the plasma membrane. The beta subunit
CC       regulates, through assembly of alpha/beta heterodimers, the number of
CC       sodium pumps transported to the plasma membrane. Implicated in genomic
CC       response to various soil bacteria that affects fitness, lifespan and
CC       brood size (By similarity). {ECO:0000250|UniProtKB:P25169,
CC       ECO:0000250|UniProtKB:Q9XUY5}.
CC   -!- SUBUNIT: The sodium/potassium-transporting ATPase is composed of a
CC       catalytic alpha subunit, an auxiliary non-catalytic beta subunit and an
CC       additional regulatory subunit. {ECO:0000305}.
CC   -!- SUBCELLULAR LOCATION: Cell membrane {ECO:0000305}; Single-pass type II
CC       membrane protein {ECO:0000305}.
CC   -!- SIMILARITY: Belongs to the X(+)/potassium ATPases subunit beta family.
CC       {ECO:0000255}.
CC   -!- SEQUENCE CAUTION:
CC       Sequence=CAP27679.2; Type=Erroneous initiation; Note=Truncated N-terminus.; Evidence={ECO:0000305};
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DR   EMBL; HE601041; CAP27679.2; ALT_INIT; Genomic_DNA.
DR   AlphaFoldDB; A8X4W9; -.
DR   SMR; A8X4W9; -.
DR   STRING; 6238.CBG07375; -.
DR   WormBase; CBG07375; CBP07601; WBGene00029440; Cbr-nkb-3.
DR   eggNOG; KOG3927; Eukaryota.
DR   HOGENOM; CLU_057702_0_0_1; -.
DR   InParanoid; A8X4W9; -.
DR   OrthoDB; 998086at2759; -.
DR   Proteomes; UP000008549; Chromosome X.
DR   GO; GO:0005890; C:sodium:potassium-exchanging ATPase complex; IBA:GO_Central.
DR   GO; GO:0001671; F:ATPase activator activity; IBA:GO_Central.
DR   GO; GO:0030007; P:cellular potassium ion homeostasis; IBA:GO_Central.
DR   GO; GO:0006883; P:cellular sodium ion homeostasis; IBA:GO_Central.
DR   GO; GO:1990573; P:potassium ion import across plasma membrane; IBA:GO_Central.
DR   GO; GO:0036376; P:sodium ion export across plasma membrane; IBA:GO_Central.
DR   Gene3D; 2.60.40.1660; -; 1.
DR   InterPro; IPR000402; Na/K_ATPase_sub_beta.
DR   InterPro; IPR038702; Na/K_ATPase_sub_beta_sf.
DR   PANTHER; PTHR11523; PTHR11523; 1.
DR   Pfam; PF00287; Na_K-ATPase; 1.
DR   PROSITE; PS00390; ATPASE_NA_K_BETA_1; 1.
PE   3: Inferred from homology;
KW   Cell membrane; Disulfide bond; Glycoprotein; Ion transport; Membrane;
KW   Potassium; Potassium transport; Reference proteome; Signal-anchor; Sodium;
KW   Sodium transport; Sodium/potassium transport; Transmembrane;
KW   Transmembrane helix; Transport.
FT   CHAIN           1..326
FT                   /note="Probable sodium/potassium-transporting ATPase
FT                   subunit beta-3"
FT                   /id="PRO_0000394763"
FT   TOPO_DOM        1..59
FT                   /note="Cytoplasmic"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        60..80
FT                   /note="Helical; Signal-anchor for type II membrane protein"
FT                   /evidence="ECO:0000255"
FT   TOPO_DOM        81..326
FT                   /note="Lumenal"
FT                   /evidence="ECO:0000255"
FT   CARBOHYD        144
FT                   /note="N-linked (GlcNAc...) asparagine"
FT                   /evidence="ECO:0000255"
FT   CARBOHYD        147
FT                   /note="N-linked (GlcNAc...) asparagine"
FT                   /evidence="ECO:0000255"
FT   DISULFID        234..291
FT                   /evidence="ECO:0000250|UniProtKB:P06583"
SQ   SEQUENCE   326 AA;  37050 MW;  AB780E6973702D41 CRC64;
     MMSSRTRKIY LFVFMFISTS LQLMNGEAKA EPETFRQFLY NKQKGTVLGR TGTSWCQITV
     FYIIFYIFLS AFFIGCLAIF LKTLDPKVPR FYGKGTIIGV NPGVGYQPWL KENPDSTLIK
     FNLQDSKSWE PYVKQLDGYF SRYNNTNDTR ECGAEDSNEA LQTDPDSLPC RFDLGLFEKA
     NCGAKDQYGF KSGKPCVVVS LNRLIGWRPV DYDGNSVPEE IKSRYKSGSI TINCEGATPF
     DKEHLGKVKY IPEAGIDGRY YPYVFLPSYQ QPIAMVKFDT IPRNKLVIVE CRAYASNIEH
     DVSTRIGMVY FELFVEDKKP VAAPAA