AT1B3_CAEEL
ID AT1B3_CAEEL Reviewed; 317 AA.
AC Q9XUY5;
DT 03-OCT-2006, integrated into UniProtKB/Swiss-Prot.
DT 01-NOV-1999, sequence version 1.
DT 03-AUG-2022, entry version 142.
DE RecName: Full=Probable sodium/potassium-transporting ATPase subunit beta-3;
DE AltName: Full=Sodium/potassium-dependent ATPase subunit beta-3;
GN Name=nkb-3; ORFNames=F55F3.3;
OS Caenorhabditis elegans.
OC Eukaryota; Metazoa; Ecdysozoa; Nematoda; Chromadorea; Rhabditida;
OC Rhabditina; Rhabditomorpha; Rhabditoidea; Rhabditidae; Peloderinae;
OC Caenorhabditis.
OX NCBI_TaxID=6239;
RN [1]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=Bristol N2;
RX PubMed=9851916; DOI=10.1126/science.282.5396.2012;
RG The C. elegans sequencing consortium;
RT "Genome sequence of the nematode C. elegans: a platform for investigating
RT biology.";
RL Science 282:2012-2018(1998).
RN [2]
RP FUNCTION.
RX PubMed=19503598; DOI=10.1371/journal.pgen.1000503;
RA Coolon J.D., Jones K.L., Todd T.C., Carr B.C., Herman M.A.;
RT "Caenorhabditis elegans genomic response to soil bacteria predicts
RT environment-specific genetic effects on life history traits.";
RL PLoS Genet. 5:E1000503-E1000503(2009).
CC -!- FUNCTION: This is the non-catalytic component of the active enzyme,
CC which catalyzes the hydrolysis of ATP coupled with the exchange of
CC Na(+) and K(+) ions across the plasma membrane. The beta subunit
CC regulates, through assembly of alpha/beta heterodimers, the number of
CC sodium pumps transported to the plasma membrane (By similarity).
CC Implicated in genomic response to various soil bacteria that affects
CC fitness, lifespan and brood size. {ECO:0000250,
CC ECO:0000269|PubMed:19503598}.
CC -!- SUBUNIT: The sodium/potassium-transporting ATPase is composed of a
CC catalytic alpha subunit, an auxiliary non-catalytic beta subunit and an
CC additional regulatory subunit. {ECO:0000305}.
CC -!- SUBCELLULAR LOCATION: Cell membrane {ECO:0000305}; Single-pass type II
CC membrane protein {ECO:0000250}.
CC -!- SIMILARITY: Belongs to the X(+)/potassium ATPases subunit beta family.
CC {ECO:0000305}.
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DR EMBL; Z81550; CAB04477.1; -; Genomic_DNA.
DR PIR; T22736; T22736.
DR RefSeq; NP_510300.1; NM_077899.4.
DR AlphaFoldDB; Q9XUY5; -.
DR SMR; Q9XUY5; -.
DR BioGRID; 46395; 5.
DR DIP; DIP-25820N; -.
DR STRING; 6239.F55F3.3; -.
DR EPD; Q9XUY5; -.
DR PaxDb; Q9XUY5; -.
DR PeptideAtlas; Q9XUY5; -.
DR EnsemblMetazoa; F55F3.3a.1; F55F3.3a.1; WBGene00010117.
DR GeneID; 181494; -.
DR KEGG; cel:CELE_F55F3.3; -.
DR UCSC; F55F3.3.1; c. elegans.
DR CTD; 181494; -.
DR WormBase; F55F3.3a; CE18746; WBGene00010117; nkb-3.
DR eggNOG; KOG3927; Eukaryota.
DR InParanoid; Q9XUY5; -.
DR OMA; PKLGKWE; -.
DR OrthoDB; 998086at2759; -.
DR PhylomeDB; Q9XUY5; -.
DR Reactome; R-CEL-210991; Basigin interactions.
DR Reactome; R-CEL-2173795; Downregulation of SMAD2/3:SMAD4 transcriptional activity.
DR Reactome; R-CEL-936837; Ion transport by P-type ATPases.
DR PRO; PR:Q9XUY5; -.
DR Proteomes; UP000001940; Chromosome X.
DR Bgee; WBGene00010117; Expressed in larva and 4 other tissues.
DR ExpressionAtlas; Q9XUY5; baseline and differential.
DR GO; GO:0005890; C:sodium:potassium-exchanging ATPase complex; IBA:GO_Central.
DR GO; GO:0001671; F:ATPase activator activity; IBA:GO_Central.
DR GO; GO:0030007; P:cellular potassium ion homeostasis; IBA:GO_Central.
DR GO; GO:0006883; P:cellular sodium ion homeostasis; IBA:GO_Central.
DR GO; GO:1990573; P:potassium ion import across plasma membrane; IBA:GO_Central.
DR GO; GO:0036376; P:sodium ion export across plasma membrane; IBA:GO_Central.
DR Gene3D; 2.60.40.1660; -; 1.
DR InterPro; IPR000402; Na/K_ATPase_sub_beta.
DR InterPro; IPR038702; Na/K_ATPase_sub_beta_sf.
DR PANTHER; PTHR11523; PTHR11523; 1.
DR Pfam; PF00287; Na_K-ATPase; 1.
DR PROSITE; PS00390; ATPASE_NA_K_BETA_1; 1.
PE 3: Inferred from homology;
KW Cell membrane; Disulfide bond; Glycoprotein; Ion transport; Membrane;
KW Potassium; Potassium transport; Reference proteome; Signal-anchor; Sodium;
KW Sodium transport; Sodium/potassium transport; Transmembrane;
KW Transmembrane helix; Transport.
FT CHAIN 1..317
FT /note="Probable sodium/potassium-transporting ATPase
FT subunit beta-3"
FT /id="PRO_0000250559"
FT TOPO_DOM 1..50
FT /note="Cytoplasmic"
FT /evidence="ECO:0000255"
FT TRANSMEM 51..71
FT /note="Helical; Signal-anchor for type II membrane protein"
FT /evidence="ECO:0000255"
FT TOPO_DOM 72..317
FT /note="Lumenal"
FT /evidence="ECO:0000255"
FT CARBOHYD 138
FT /note="N-linked (GlcNAc...) asparagine"
FT /evidence="ECO:0000255"
FT DISULFID 173..187
FT /evidence="ECO:0000250"
FT DISULFID 225..282
FT /evidence="ECO:0000250"
SQ SEQUENCE 317 AA; 35750 MW; 71189FBE7CA785C2 CRC64;
MTNGGRNGEE NKNLMNGEAK AEPETFAQFL YNKDKGTVLG RTGTSWCQIT VFYIIFYIFL
SAFFIGCLSI FLRTLDPKVP RFYGKGTIIG VNPGVGYQPW LKENPDSTLI KFNLQDSKSW
EPYVKQLDNY LSKYKNTNET RDCGASDNND ALETDTDTFP CRFDLGLFEK ANCGAKDQYG
YKSGKPCVAV SLNRLIGWRP VNYDDGSVPE EIKGRYKPGS ITINCEGATS FDKEHLGKVK
YIPETGIDGR YYPYVFVPSY QQPIAMVKFD TIPRNKLVIV ECRAYASNIE HDISTRLGMV
YFELFVEDKK PVAAPAA
