AT1B3_CHICK
ID AT1B3_CHICK Reviewed; 280 AA.
AC P33879;
DT 01-FEB-1994, integrated into UniProtKB/Swiss-Prot.
DT 01-FEB-1994, sequence version 1.
DT 03-AUG-2022, entry version 146.
DE RecName: Full=Sodium/potassium-transporting ATPase subunit beta-3;
DE AltName: Full=Sodium/potassium-dependent ATPase subunit beta-3;
GN Name=ATP1B3;
OS Gallus gallus (Chicken).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC Archelosauria; Archosauria; Dinosauria; Saurischia; Theropoda;
OC Coelurosauria; Aves; Neognathae; Galloanserae; Galliformes; Phasianidae;
OC Phasianinae; Gallus.
OX NCBI_TaxID=9031;
RN [1]
RP NUCLEOTIDE SEQUENCE [MRNA].
RC STRAIN=White leghorn; TISSUE=Brain;
RX PubMed=8391844; DOI=10.1016/0005-2736(93)90219-p;
RA Lemas M., Fambrough D.M.;
RT "Sequence analysis of DNA encoding an avian Na+,K(+)-ATPase beta 2-
RT subunit.";
RL Biochim. Biophys. Acta 1149:339-342(1993).
CC -!- FUNCTION: This is the non-catalytic component of the active enzyme,
CC which catalyzes the hydrolysis of ATP coupled with the exchange of
CC Na(+) and K(+) ions across the plasma membrane. The exact function of
CC the beta-3 subunit is not known.
CC -!- SUBUNIT: The sodium/potassium-transporting ATPase is composed of a
CC catalytic alpha subunit, an auxiliary non-catalytic beta subunit and an
CC additional regulatory subunit. {ECO:0000305}.
CC -!- SUBCELLULAR LOCATION: Cell membrane {ECO:0000250|UniProtKB:P54709};
CC Single-pass type II membrane protein.
CC -!- TISSUE SPECIFICITY: Predominantly expressed in brain.
CC -!- SIMILARITY: Belongs to the X(+)/potassium ATPases subunit beta family.
CC {ECO:0000305}.
CC -!- CAUTION: Was originally thought to be the beta-2 subunit.
CC {ECO:0000305|PubMed:8391844}.
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DR EMBL; L13208; AAA02625.1; -; mRNA.
DR PIR; I50396; I50396.
DR RefSeq; NP_990866.1; NM_205535.1.
DR AlphaFoldDB; P33879; -.
DR SMR; P33879; -.
DR STRING; 9031.ENSGALP00000004355; -.
DR PaxDb; P33879; -.
DR Ensembl; ENSGALT00000056315; ENSGALP00000054148; ENSGALG00000002764.
DR GeneID; 396549; -.
DR KEGG; gga:396549; -.
DR CTD; 483; -.
DR VEuPathDB; HostDB:geneid_396549; -.
DR eggNOG; KOG3927; Eukaryota.
DR GeneTree; ENSGT01030000234579; -.
DR HOGENOM; CLU_057702_1_1_1; -.
DR InParanoid; P33879; -.
DR OrthoDB; 998086at2759; -.
DR PhylomeDB; P33879; -.
DR TreeFam; TF314618; -.
DR Reactome; R-GGA-210991; Basigin interactions.
DR Reactome; R-GGA-5578775; Ion homeostasis.
DR Reactome; R-GGA-936837; Ion transport by P-type ATPases.
DR PRO; PR:P33879; -.
DR Proteomes; UP000000539; Chromosome 9.
DR Bgee; ENSGALG00000002764; Expressed in cerebellum and 13 other tissues.
DR ExpressionAtlas; P33879; baseline and differential.
DR GO; GO:0005890; C:sodium:potassium-exchanging ATPase complex; IBA:GO_Central.
DR GO; GO:0001671; F:ATPase activator activity; IBA:GO_Central.
DR GO; GO:0030007; P:cellular potassium ion homeostasis; IBA:GO_Central.
DR GO; GO:0006883; P:cellular sodium ion homeostasis; IBA:GO_Central.
DR GO; GO:1990573; P:potassium ion import across plasma membrane; IBA:GO_Central.
DR GO; GO:0036376; P:sodium ion export across plasma membrane; IBA:GO_Central.
DR Gene3D; 2.60.40.1660; -; 1.
DR InterPro; IPR000402; Na/K_ATPase_sub_beta.
DR InterPro; IPR038702; Na/K_ATPase_sub_beta_sf.
DR PANTHER; PTHR11523; PTHR11523; 1.
DR Pfam; PF00287; Na_K-ATPase; 1.
DR TIGRFAMs; TIGR01107; Na_K_ATPase_bet; 1.
DR PROSITE; PS00390; ATPASE_NA_K_BETA_1; 1.
DR PROSITE; PS00391; ATPASE_NA_K_BETA_2; 1.
PE 2: Evidence at transcript level;
KW Cell membrane; Disulfide bond; Glycoprotein; Ion transport; Membrane;
KW Potassium; Potassium transport; Reference proteome; Signal-anchor; Sodium;
KW Sodium transport; Sodium/potassium transport; Transmembrane;
KW Transmembrane helix; Transport.
FT CHAIN 1..280
FT /note="Sodium/potassium-transporting ATPase subunit beta-3"
FT /id="PRO_0000219111"
FT TOPO_DOM 1..37
FT /note="Cytoplasmic"
FT /evidence="ECO:0000255"
FT TRANSMEM 38..62
FT /note="Helical; Signal-anchor for type II membrane protein"
FT /evidence="ECO:0000255"
FT TOPO_DOM 63..280
FT /note="Extracellular"
FT /evidence="ECO:0000255"
FT CARBOHYD 96
FT /note="N-linked (GlcNAc...) asparagine"
FT /evidence="ECO:0000255"
FT CARBOHYD 148
FT /note="N-linked (GlcNAc...) asparagine"
FT /evidence="ECO:0000255"
FT CARBOHYD 241
FT /note="N-linked (GlcNAc...) asparagine"
FT /evidence="ECO:0000255"
FT DISULFID 128..145
FT /evidence="ECO:0000250"
FT DISULFID 155..171
FT /evidence="ECO:0000250"
FT DISULFID 192..251
FT /evidence="ECO:0000250"
SQ SEQUENCE 280 AA; 31859 MW; 48928F19CA4B701B CRC64;
MSKETKKPFR QSVAEWRQFV YNPNSGEFLG RTAKSWGLIL LFYLVFYGFL AALFTFTMWV
MLQTLSNDIP KYRDRISSPG LMISPKPDTA LEFYFNKSDA QSYAEYVSTL RKFLETYDDS
KQSQNINCTP GKVFDQNDVA VKKACRFNLS ELGQCSGKED KTFGYSKGTP CVLVKMNRII
GLKPEGEPYI QCTSKEPGAV EINYFPSGGL IDLMYFPYYG KTLHAHYLQP LVAVQLAINS
NSTNEEIAIE CKILGSPNLK NEDDRDKFLG RIAFKVEMTE
