ID   AT1B4_BOVIN             Reviewed;         355 AA.
AC   A7MB71;
DT   18-MAY-2010, integrated into UniProtKB/Swiss-Prot.
DT   02-OCT-2007, sequence version 1.
DT   03-AUG-2022, entry version 76.
DE   RecName: Full=Protein ATP1B4;
DE   AltName: Full=X,K-ATPase subunit beta-m;
DE   AltName: Full=X/potassium-transporting ATPase subunit beta-m;
GN   Name=ATP1B4;
OS   Bos taurus (Bovine).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC   Eutheria; Laurasiatheria; Artiodactyla; Ruminantia; Pecora; Bovidae;
OC   Bovinae; Bos.
OX   NCBI_TaxID=9913;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
RC   STRAIN=Hereford; TISSUE=Fetal muscle;
RG   NIH - Mammalian Gene Collection (MGC) project;
RL   Submitted (JUL-2007) to the EMBL/GenBank/DDBJ databases.
CC   -!- FUNCTION: May act as a transcriptional coregulator during muscle
CC       development through its interaction with SNW1. Has lost its ancestral
CC       function as a Na,K-ATPase beta-subunit (By similarity). {ECO:0000250}.
CC   -!- SUBUNIT: Associates with a SMAD7-transcriptional complex. Interacts
CC       with SNW1 and TOR1AIP1. Does not associate with known Na,K-ATPase
CC       alpha-subunits (By similarity). {ECO:0000250}.
CC   -!- SUBCELLULAR LOCATION: Nucleus inner membrane {ECO:0000250}; Single-pass
CC       type II membrane protein {ECO:0000250}. Note=Detected in nuclear
CC       envelops. {ECO:0000250}.
CC   -!- SIMILARITY: Belongs to the X(+)/potassium ATPases subunit beta family.
CC       {ECO:0000305}.
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DR   EMBL; BC151371; AAI51372.1; -; mRNA.
DR   RefSeq; NP_001095389.1; NM_001101919.1.
DR   AlphaFoldDB; A7MB71; -.
DR   SMR; A7MB71; -.
DR   STRING; 9913.ENSBTAP00000011741; -.
DR   PaxDb; A7MB71; -.
DR   Ensembl; ENSBTAT00000011740; ENSBTAP00000011741; ENSBTAG00000008920.
DR   GeneID; 510026; -.
DR   KEGG; bta:510026; -.
DR   CTD; 23439; -.
DR   VEuPathDB; HostDB:ENSBTAG00000008920; -.
DR   VGNC; VGNC:26288; ATP1B4.
DR   eggNOG; KOG3927; Eukaryota.
DR   GeneTree; ENSGT01030000234579; -.
DR   HOGENOM; CLU_057702_1_0_1; -.
DR   InParanoid; A7MB71; -.
DR   OMA; GVQYDTH; -.
DR   OrthoDB; 998086at2759; -.
DR   TreeFam; TF314618; -.
DR   Reactome; R-BTA-2173795; Downregulation of SMAD2/3:SMAD4 transcriptional activity.
DR   Proteomes; UP000009136; Chromosome X.
DR   Bgee; ENSBTAG00000008920; Expressed in supraspinatus muscle and 26 other tissues.
DR   GO; GO:0005637; C:nuclear inner membrane; ISS:UniProtKB.
DR   GO; GO:0005890; C:sodium:potassium-exchanging ATPase complex; IEA:InterPro.
DR   GO; GO:0006813; P:potassium ion transport; IEA:InterPro.
DR   GO; GO:0006355; P:regulation of transcription, DNA-templated; ISS:UniProtKB.
DR   GO; GO:0006814; P:sodium ion transport; IEA:InterPro.
DR   Gene3D; 2.60.40.1660; -; 1.
DR   InterPro; IPR000402; Na/K_ATPase_sub_beta.
DR   InterPro; IPR038702; Na/K_ATPase_sub_beta_sf.
DR   PANTHER; PTHR11523; PTHR11523; 1.
DR   Pfam; PF00287; Na_K-ATPase; 1.
DR   TIGRFAMs; TIGR01107; Na_K_ATPase_bet; 1.
DR   PROSITE; PS00390; ATPASE_NA_K_BETA_1; 1.
DR   PROSITE; PS00391; ATPASE_NA_K_BETA_2; 1.
PE   2: Evidence at transcript level;
KW   Membrane; Nucleus; Reference proteome; Signal-anchor; Transcription;
KW   Transcription regulation; Transmembrane; Transmembrane helix.
FT   CHAIN           1..355
FT                   /note="Protein ATP1B4"
FT                   /id="PRO_0000393963"
FT   TOPO_DOM        1..108
FT                   /note="Nuclear"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        109..129
FT                   /note="Helical; Signal-anchor for type II membrane protein"
FT                   /evidence="ECO:0000255"
FT   TOPO_DOM        130..355
FT                   /note="Perinuclear space"
FT                   /evidence="ECO:0000255"
FT   REGION          33..77
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        33..71
FT                   /note="Acidic residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ   SEQUENCE   355 AA;  41473 MW;  DC6A9541CBAD915B CRC64;
     MRRQLRSRRA PALPYGYRYR LDDQDEVNQN YLADEEEEAE EEARVMVVPD LEEEEEEEEE
     KEEEEKEEED SHSQETDSAW WRKLQIVNEY LWDPEKRTSL ARTGQSWSLI LVIYFFFYAS
     LAAVITLCMY TLFLTISPYM PTFTERVKPP GVMIRPFAHS LNFNFNVSEP DTWQHYVISL
     NGFLQGYNDS LQEEMNVDCP PGQYFIQDGD EDEDKKACQF KRSFLKNCSG LEDPTFGYST
     GQPCILLKMN RIVGFRPERG DPVKVSCKVQ RGDENDIRSI NYYPESASFD LRYYPYYGKL
     THVNYTSPLV AMHFTDVVKN QAVPVQCQLK GKGIINDVIN DRFVGRVIFT LNIET