AT1B4_MOUSE
ID AT1B4_MOUSE Reviewed; 356 AA.
AC Q99ME6; Q543D0; Q99ME5;
DT 16-NOV-2001, integrated into UniProtKB/Swiss-Prot.
DT 01-JUN-2001, sequence version 1.
DT 03-AUG-2022, entry version 142.
DE RecName: Full=Protein ATP1B4;
DE AltName: Full=X,K-ATPase subunit beta-m;
DE AltName: Full=X/potassium-transporting ATPase subunit beta-m;
GN Name=Atp1b4;
OS Mus musculus (Mouse).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae;
OC Murinae; Mus; Mus.
OX NCBI_TaxID=10090;
RN [1]
RP NUCLEOTIDE SEQUENCE [MRNA] (ISOFORMS A AND B).
RC STRAIN=ICR;
RA Pestov N.B., Shakhparonov M.I., Modyanov N.N.;
RL Submitted (FEB-2001) to the EMBL/GenBank/DDBJ databases.
RN [2]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
RC STRAIN=C57BL/6J; TISSUE=Eye;
RX PubMed=16141072; DOI=10.1126/science.1112014;
RA Carninci P., Kasukawa T., Katayama S., Gough J., Frith M.C., Maeda N.,
RA Oyama R., Ravasi T., Lenhard B., Wells C., Kodzius R., Shimokawa K.,
RA Bajic V.B., Brenner S.E., Batalov S., Forrest A.R., Zavolan M., Davis M.J.,
RA Wilming L.G., Aidinis V., Allen J.E., Ambesi-Impiombato A., Apweiler R.,
RA Aturaliya R.N., Bailey T.L., Bansal M., Baxter L., Beisel K.W., Bersano T.,
RA Bono H., Chalk A.M., Chiu K.P., Choudhary V., Christoffels A.,
RA Clutterbuck D.R., Crowe M.L., Dalla E., Dalrymple B.P., de Bono B.,
RA Della Gatta G., di Bernardo D., Down T., Engstrom P., Fagiolini M.,
RA Faulkner G., Fletcher C.F., Fukushima T., Furuno M., Futaki S.,
RA Gariboldi M., Georgii-Hemming P., Gingeras T.R., Gojobori T., Green R.E.,
RA Gustincich S., Harbers M., Hayashi Y., Hensch T.K., Hirokawa N., Hill D.,
RA Huminiecki L., Iacono M., Ikeo K., Iwama A., Ishikawa T., Jakt M.,
RA Kanapin A., Katoh M., Kawasawa Y., Kelso J., Kitamura H., Kitano H.,
RA Kollias G., Krishnan S.P., Kruger A., Kummerfeld S.K., Kurochkin I.V.,
RA Lareau L.F., Lazarevic D., Lipovich L., Liu J., Liuni S., McWilliam S.,
RA Madan Babu M., Madera M., Marchionni L., Matsuda H., Matsuzawa S., Miki H.,
RA Mignone F., Miyake S., Morris K., Mottagui-Tabar S., Mulder N., Nakano N.,
RA Nakauchi H., Ng P., Nilsson R., Nishiguchi S., Nishikawa S., Nori F.,
RA Ohara O., Okazaki Y., Orlando V., Pang K.C., Pavan W.J., Pavesi G.,
RA Pesole G., Petrovsky N., Piazza S., Reed J., Reid J.F., Ring B.Z.,
RA Ringwald M., Rost B., Ruan Y., Salzberg S.L., Sandelin A., Schneider C.,
RA Schoenbach C., Sekiguchi K., Semple C.A., Seno S., Sessa L., Sheng Y.,
RA Shibata Y., Shimada H., Shimada K., Silva D., Sinclair B., Sperling S.,
RA Stupka E., Sugiura K., Sultana R., Takenaka Y., Taki K., Tammoja K.,
RA Tan S.L., Tang S., Taylor M.S., Tegner J., Teichmann S.A., Ueda H.R.,
RA van Nimwegen E., Verardo R., Wei C.L., Yagi K., Yamanishi H.,
RA Zabarovsky E., Zhu S., Zimmer A., Hide W., Bult C., Grimmond S.M.,
RA Teasdale R.D., Liu E.T., Brusic V., Quackenbush J., Wahlestedt C.,
RA Mattick J.S., Hume D.A., Kai C., Sasaki D., Tomaru Y., Fukuda S.,
RA Kanamori-Katayama M., Suzuki M., Aoki J., Arakawa T., Iida J., Imamura K.,
RA Itoh M., Kato T., Kawaji H., Kawagashira N., Kawashima T., Kojima M.,
RA Kondo S., Konno H., Nakano K., Ninomiya N., Nishio T., Okada M., Plessy C.,
RA Shibata K., Shiraki T., Suzuki S., Tagami M., Waki K., Watahiki A.,
RA Okamura-Oho Y., Suzuki H., Kawai J., Hayashizaki Y.;
RT "The transcriptional landscape of the mammalian genome.";
RL Science 309:1559-1563(2005).
RN [3]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=C57BL/6J;
RX PubMed=19468303; DOI=10.1371/journal.pbio.1000112;
RA Church D.M., Goodstadt L., Hillier L.W., Zody M.C., Goldstein S., She X.,
RA Bult C.J., Agarwala R., Cherry J.L., DiCuccio M., Hlavina W., Kapustin Y.,
RA Meric P., Maglott D., Birtle Z., Marques A.C., Graves T., Zhou S.,
RA Teague B., Potamousis K., Churas C., Place M., Herschleb J., Runnheim R.,
RA Forrest D., Amos-Landgraf J., Schwartz D.C., Cheng Z., Lindblad-Toh K.,
RA Eichler E.E., Ponting C.P.;
RT "Lineage-specific biology revealed by a finished genome assembly of the
RT mouse.";
RL PLoS Biol. 7:E1000112-E1000112(2009).
RN [4]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RA Mural R.J., Adams M.D., Myers E.W., Smith H.O., Venter J.C.;
RL Submitted (JUL-2005) to the EMBL/GenBank/DDBJ databases.
RN [5]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
RC TISSUE=Brain;
RX PubMed=15489334; DOI=10.1101/gr.2596504;
RG The MGC Project Team;
RT "The status, quality, and expansion of the NIH full-length cDNA project:
RT the Mammalian Gene Collection (MGC).";
RL Genome Res. 14:2121-2127(2004).
RN [6]
RP TISSUE SPECIFICITY, AND DEVELOPMENTAL STAGE.
RX PubMed=14656723; DOI=10.1152/ajpcell.00358.2003;
RA Zhao H., Pestov N.B., Korneenko T.V., Shakhparonov M.I., Modyanov N.N.;
RT "Accumulation of beta (m), a structural member of X,K-ATPase beta-subunit
RT family, in nuclear envelopes of perinatal myocytes.";
RL Am. J. Physiol. 286:C757-C767(2004).
RN [7]
RP INTERACTION WITH SNW1.
RX PubMed=17592128; DOI=10.1073/pnas.0704809104;
RA Pestov N.B., Ahmad N., Korneenko T.V., Zhao H., Radkov R., Schaer D.,
RA Roy S., Bibert S., Geering K., Modyanov N.N.;
RT "Evolution of Na,K-ATPase betam-subunit into a coregulator of transcription
RT in placental mammals.";
RL Proc. Natl. Acad. Sci. U.S.A. 104:11215-11220(2007).
CC -!- FUNCTION: May act as a transcriptional coregulator during muscle
CC development through its interaction with SNW1. Has lost its ancestral
CC function as a Na,K-ATPase beta-subunit (By similarity). {ECO:0000250}.
CC -!- SUBUNIT: Associates with a SMAD7-transcriptional complex. Interacts
CC with TOR1AIP1. Does not associate with known Na,K-ATPase alpha-subunits
CC (By similarity). Interacts with SNW1. {ECO:0000250,
CC ECO:0000269|PubMed:17592128}.
CC -!- SUBCELLULAR LOCATION: Nucleus inner membrane {ECO:0000250}; Single-pass
CC type II membrane protein {ECO:0000250}. Note=Detected in nuclear
CC envelops. {ECO:0000250}.
CC -!- ALTERNATIVE PRODUCTS:
CC Event=Alternative splicing; Named isoforms=2;
CC Name=A;
CC IsoId=Q99ME6-1; Sequence=Displayed;
CC Name=B;
CC IsoId=Q99ME6-2; Sequence=VSP_000352;
CC -!- TISSUE SPECIFICITY: Expressed in skeletal muscle (at protein level).
CC Expressed during postnatal development in skeletal muscle and heart.
CC {ECO:0000269|PubMed:14656723}.
CC -!- DEVELOPMENTAL STAGE: Expressed in embryo 15.5 dpc, onward.
CC {ECO:0000269|PubMed:14656723}.
CC -!- SIMILARITY: Belongs to the X(+)/potassium ATPases subunit beta family.
CC {ECO:0000305}.
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DR EMBL; AF348324; AAK30148.1; -; mRNA.
DR EMBL; AF348325; AAK30149.1; -; mRNA.
DR EMBL; AK053500; BAC35406.1; -; mRNA.
DR EMBL; AL513347; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR EMBL; CH466570; EDL29013.1; -; Genomic_DNA.
DR EMBL; BC137924; AAI37925.1; -; mRNA.
DR CCDS; CCDS30090.1; -. [Q99ME6-1]
DR CCDS; CCDS72368.1; -. [Q99ME6-2]
DR RefSeq; NP_001277318.1; NM_001290389.1. [Q99ME6-2]
DR RefSeq; NP_598451.1; NM_133690.3. [Q99ME6-1]
DR AlphaFoldDB; Q99ME6; -.
DR SMR; Q99ME6; -.
DR DIP; DIP-60965N; -.
DR IntAct; Q99ME6; 3.
DR STRING; 10090.ENSMUSP00000016471; -.
DR PhosphoSitePlus; Q99ME6; -.
DR PaxDb; Q99ME6; -.
DR PRIDE; Q99ME6; -.
DR ProteomicsDB; 281817; -. [Q99ME6-1]
DR ProteomicsDB; 281818; -. [Q99ME6-2]
DR Antibodypedia; 44620; 48 antibodies from 13 providers.
DR DNASU; 67821; -.
DR Ensembl; ENSMUST00000016471; ENSMUSP00000016471; ENSMUSG00000016327. [Q99ME6-1]
DR Ensembl; ENSMUST00000115134; ENSMUSP00000110787; ENSMUSG00000016327. [Q99ME6-2]
DR GeneID; 67821; -.
DR KEGG; mmu:67821; -.
DR UCSC; uc009szt.2; mouse. [Q99ME6-1]
DR CTD; 23439; -.
DR MGI; MGI:1915071; Atp1b4.
DR VEuPathDB; HostDB:ENSMUSG00000016327; -.
DR eggNOG; KOG3927; Eukaryota.
DR GeneTree; ENSGT01030000234579; -.
DR HOGENOM; CLU_057702_1_0_1; -.
DR InParanoid; Q99ME6; -.
DR OMA; GVQYDTH; -.
DR OrthoDB; 998086at2759; -.
DR PhylomeDB; Q99ME6; -.
DR TreeFam; TF314618; -.
DR Reactome; R-MMU-2173795; Downregulation of SMAD2/3:SMAD4 transcriptional activity.
DR BioGRID-ORCS; 67821; 1 hit in 73 CRISPR screens.
DR ChiTaRS; Atp1b4; mouse.
DR PRO; PR:Q99ME6; -.
DR Proteomes; UP000000589; Chromosome X.
DR RNAct; Q99ME6; protein.
DR Bgee; ENSMUSG00000016327; Expressed in late embryo and 56 other tissues.
DR ExpressionAtlas; Q99ME6; baseline and differential.
DR Genevisible; Q99ME6; MM.
DR GO; GO:0000785; C:chromatin; ISO:MGI.
DR GO; GO:0005635; C:nuclear envelope; ISO:MGI.
DR GO; GO:0005637; C:nuclear inner membrane; ISS:UniProtKB.
DR GO; GO:0005634; C:nucleus; IDA:MGI.
DR GO; GO:0005890; C:sodium:potassium-exchanging ATPase complex; IEA:InterPro.
DR GO; GO:0006813; P:potassium ion transport; IEA:InterPro.
DR GO; GO:0006355; P:regulation of transcription, DNA-templated; ISS:UniProtKB.
DR GO; GO:0006814; P:sodium ion transport; IEA:InterPro.
DR Gene3D; 2.60.40.1660; -; 1.
DR InterPro; IPR000402; Na/K_ATPase_sub_beta.
DR InterPro; IPR038702; Na/K_ATPase_sub_beta_sf.
DR PANTHER; PTHR11523; PTHR11523; 1.
DR Pfam; PF00287; Na_K-ATPase; 1.
DR TIGRFAMs; TIGR01107; Na_K_ATPase_bet; 1.
DR PROSITE; PS00390; ATPASE_NA_K_BETA_1; 1.
DR PROSITE; PS00391; ATPASE_NA_K_BETA_2; 1.
PE 1: Evidence at protein level;
KW Alternative splicing; Membrane; Nucleus; Reference proteome; Signal-anchor;
KW Transcription; Transcription regulation; Transmembrane;
KW Transmembrane helix.
FT CHAIN 1..356
FT /note="Protein ATP1B4"
FT /id="PRO_0000219123"
FT TOPO_DOM 1..109
FT /note="Nuclear"
FT /evidence="ECO:0000255"
FT TRANSMEM 110..130
FT /note="Helical; Signal-anchor for type II membrane protein"
FT /evidence="ECO:0000255"
FT TOPO_DOM 131..356
FT /note="Perinuclear space"
FT /evidence="ECO:0000255"
FT REGION 26..78
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 29..71
FT /note="Acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT VAR_SEQ 106..109
FT /note="Missing (in isoform B)"
FT /evidence="ECO:0000303|Ref.1"
FT /id="VSP_000352"
SQ SEQUENCE 356 AA; 41401 MW; 1AD12A8D7AA720F2 CRC64;
MRRQLRSRRA PAFPYGYRYR LDDQDEANHN YLADEEEEAE EEAQVMMVPG LEEEEEEEEG
KEEEEEREEE EGQGQSTGSA WWRKLQIVNE YLWDPEKRMS LARTGQSRSL ILVIYFFFYA
SLAAVITLFI YMLFLAISPY MPTFTEQVKP PGVMIRPFAH SLNFNFNVSE PETWQRYVIS
LNGFLQGYND SLQEEMNIDC PPGRYFIQDG DEDEDKKACQ FKRSFLKNCS GLEDPTFGYS
TGQPCILLKM NRIVGFRPEF GDPVKVSCKV QKGDENDIRS INYYPESASF DLRYYPYYGK
LTHVNYTSPL VAMHFTDVVK NQAVPVQCQL KGKGIVNDVI NDRFVGRIIF TLNIET
