AT1B4_PIG
ID AT1B4_PIG Reviewed; 355 AA.
AC Q9BDK6; Q9BDK5;
DT 16-NOV-2001, integrated into UniProtKB/Swiss-Prot.
DT 01-JUN-2001, sequence version 1.
DT 03-AUG-2022, entry version 117.
DE RecName: Full=Protein ATP1B4;
DE AltName: Full=X,K-ATPase subunit beta-m;
DE AltName: Full=X/potassium-transporting ATPase subunit beta-m;
GN Name=ATP1B4;
OS Sus scrofa (Pig).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Laurasiatheria; Artiodactyla; Suina; Suidae; Sus.
OX NCBI_TaxID=9823;
RN [1]
RP NUCLEOTIDE SEQUENCE [MRNA] (ISOFORMS A AND B).
RC TISSUE=Skeletal muscle;
RA Pestov N.B., Shakhparonov M.I., Modyanov N.N.;
RL Submitted (FEB-2001) to the EMBL/GenBank/DDBJ databases.
RN [2]
RP SUBCELLULAR LOCATION, AND TISSUE SPECIFICITY.
RX PubMed=14656723; DOI=10.1152/ajpcell.00358.2003;
RA Zhao H., Pestov N.B., Korneenko T.V., Shakhparonov M.I., Modyanov N.N.;
RT "Accumulation of beta (m), a structural member of X,K-ATPase beta-subunit
RT family, in nuclear envelopes of perinatal myocytes.";
RL Am. J. Physiol. 286:C757-C767(2004).
CC -!- FUNCTION: May act as a transcriptional coregulator during muscle
CC development through its interaction with SNW1. Has lost its ancestral
CC function as a Na,K-ATPase beta-subunit (By similarity). {ECO:0000250}.
CC -!- SUBUNIT: Associates with a SMAD7-transcriptional complex. Interacts
CC with SNW1 and TOR1AIP1. Does not associate with known Na,K-ATPase
CC alpha-subunits (By similarity). {ECO:0000250}.
CC -!- SUBCELLULAR LOCATION: Nucleus inner membrane
CC {ECO:0000269|PubMed:14656723}; Single-pass type II membrane protein
CC {ECO:0000269|PubMed:14656723}. Note=Detected in nuclear envelops.
CC -!- ALTERNATIVE PRODUCTS:
CC Event=Alternative splicing; Named isoforms=2;
CC Name=A;
CC IsoId=Q9BDK6-1; Sequence=Displayed;
CC Name=B;
CC IsoId=Q9BDK6-2; Sequence=VSP_000353;
CC -!- TISSUE SPECIFICITY: Expressed in skeletal muscle (at protein level).
CC Expressed during postnatal development in skeletal muscle and heart.
CC {ECO:0000269|PubMed:14656723}.
CC -!- SIMILARITY: Belongs to the X(+)/potassium ATPases subunit beta family.
CC {ECO:0000305}.
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DR EMBL; AF348326; AAK30150.1; -; mRNA.
DR EMBL; AF348327; AAK30151.2; -; mRNA.
DR RefSeq; NP_999297.1; NM_214132.1. [Q9BDK6-1]
DR RefSeq; XP_005673910.1; XM_005673853.2. [Q9BDK6-2]
DR AlphaFoldDB; Q9BDK6; -.
DR SMR; Q9BDK6; -.
DR STRING; 9823.ENSSSCP00000029611; -.
DR PaxDb; Q9BDK6; -.
DR PeptideAtlas; Q9BDK6; -.
DR Ensembl; ENSSSCT00000013785; ENSSSCP00000013404; ENSSSCG00000012606. [Q9BDK6-2]
DR Ensembl; ENSSSCT00000032976; ENSSSCP00000029611; ENSSSCG00000012606. [Q9BDK6-1]
DR Ensembl; ENSSSCT00005004511; ENSSSCP00005002641; ENSSSCG00005002815. [Q9BDK6-1]
DR Ensembl; ENSSSCT00015086346; ENSSSCP00015035114; ENSSSCG00015064408. [Q9BDK6-1]
DR Ensembl; ENSSSCT00015086767; ENSSSCP00015035329; ENSSSCG00015064408. [Q9BDK6-2]
DR Ensembl; ENSSSCT00030071757; ENSSSCP00030032714; ENSSSCG00030051494. [Q9BDK6-1]
DR Ensembl; ENSSSCT00030071826; ENSSSCP00030032744; ENSSSCG00030051494. [Q9BDK6-2]
DR Ensembl; ENSSSCT00035097157; ENSSSCP00035040961; ENSSSCG00035071841. [Q9BDK6-1]
DR Ensembl; ENSSSCT00035097227; ENSSSCP00035040998; ENSSSCG00035071841. [Q9BDK6-2]
DR Ensembl; ENSSSCT00040068052; ENSSSCP00040028930; ENSSSCG00040050376. [Q9BDK6-1]
DR Ensembl; ENSSSCT00040068382; ENSSSCP00040029099; ENSSSCG00040050376. [Q9BDK6-2]
DR Ensembl; ENSSSCT00045024986; ENSSSCP00045017257; ENSSSCG00045014669. [Q9BDK6-1]
DR Ensembl; ENSSSCT00045025012; ENSSSCP00045017274; ENSSSCG00045014669. [Q9BDK6-2]
DR Ensembl; ENSSSCT00050091319; ENSSSCP00050039272; ENSSSCG00050067009. [Q9BDK6-1]
DR Ensembl; ENSSSCT00050091332; ENSSSCP00050039280; ENSSSCG00050067009. [Q9BDK6-2]
DR Ensembl; ENSSSCT00055010393; ENSSSCP00055008205; ENSSSCG00055005325. [Q9BDK6-1]
DR Ensembl; ENSSSCT00055010425; ENSSSCP00055008233; ENSSSCG00055005325. [Q9BDK6-2]
DR Ensembl; ENSSSCT00060044026; ENSSSCP00060018783; ENSSSCG00060032513. [Q9BDK6-1]
DR Ensembl; ENSSSCT00060044058; ENSSSCP00060018795; ENSSSCG00060032513. [Q9BDK6-2]
DR Ensembl; ENSSSCT00065008229; ENSSSCP00065003472; ENSSSCG00065006127. [Q9BDK6-1]
DR Ensembl; ENSSSCT00065008246; ENSSSCP00065003483; ENSSSCG00065006127. [Q9BDK6-2]
DR Ensembl; ENSSSCT00070058408; ENSSSCP00070049669; ENSSSCG00070029108. [Q9BDK6-1]
DR GeneID; 397245; -.
DR KEGG; ssc:397245; -.
DR CTD; 23439; -.
DR eggNOG; KOG3927; Eukaryota.
DR GeneTree; ENSGT01030000234579; -.
DR HOGENOM; CLU_057702_1_0_1; -.
DR InParanoid; Q9BDK6; -.
DR OMA; GVQYDTH; -.
DR OrthoDB; 998086at2759; -.
DR TreeFam; TF314618; -.
DR Reactome; R-SSC-2173795; Downregulation of SMAD2/3:SMAD4 transcriptional activity.
DR Proteomes; UP000008227; Chromosome X.
DR Proteomes; UP000314985; Unassembled WGS sequence.
DR Bgee; ENSSSCG00000012606; Expressed in skeletal muscle tissue and 7 other tissues.
DR ExpressionAtlas; Q9BDK6; baseline and differential.
DR Genevisible; Q9BDK6; SS.
DR GO; GO:0005635; C:nuclear envelope; IDA:MGI.
DR GO; GO:0005637; C:nuclear inner membrane; IDA:UniProtKB.
DR GO; GO:0005890; C:sodium:potassium-exchanging ATPase complex; IEA:InterPro.
DR GO; GO:0006813; P:potassium ion transport; IEA:InterPro.
DR GO; GO:0006355; P:regulation of transcription, DNA-templated; ISS:UniProtKB.
DR GO; GO:0006814; P:sodium ion transport; IEA:InterPro.
DR Gene3D; 2.60.40.1660; -; 1.
DR InterPro; IPR000402; Na/K_ATPase_sub_beta.
DR InterPro; IPR038702; Na/K_ATPase_sub_beta_sf.
DR PANTHER; PTHR11523; PTHR11523; 1.
DR Pfam; PF00287; Na_K-ATPase; 1.
DR TIGRFAMs; TIGR01107; Na_K_ATPase_bet; 1.
DR PROSITE; PS00390; ATPASE_NA_K_BETA_1; 1.
DR PROSITE; PS00391; ATPASE_NA_K_BETA_2; 1.
PE 1: Evidence at protein level;
KW Alternative splicing; Membrane; Nucleus; Reference proteome; Signal-anchor;
KW Transcription; Transcription regulation; Transmembrane;
KW Transmembrane helix.
FT CHAIN 1..355
FT /note="Protein ATP1B4"
FT /id="PRO_0000219124"
FT TOPO_DOM 1..108
FT /note="Nuclear"
FT /evidence="ECO:0000255"
FT TRANSMEM 109..129
FT /note="Helical; Signal-anchor for type II membrane protein"
FT /evidence="ECO:0000255"
FT TOPO_DOM 130..355
FT /note="Perinuclear space"
FT /evidence="ECO:0000255"
FT REGION 35..76
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 51..66
FT /note="Acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT VAR_SEQ 105..108
FT /note="Missing (in isoform B)"
FT /evidence="ECO:0000303|Ref.1"
FT /id="VSP_000353"
SQ SEQUENCE 355 AA; 41311 MW; B15842316E4EC177 CRC64;
MRRQLRSRRA PAFPYGYGYR LDDQDEVNQN YLADEEEEAE EARVMVVPDL EEEEKEEEEE
KEEDEKEEEE SHHQDTRSAW WQKLQIVNEY LWDPEKRMSL ARTGQSLSLL LVIYFFFYAS
LAAVITLCMY TLFLTISPYV PTFTERVKPP GVMIRPFAHS LNFNFNVSEP DTWQHYVISL
NGFLQGYNDS LQEEMNVDCP PGQYFIQDGD EDEDKKACQF KRSFLKNCSG LEDPTFGYST
GQPCILLKMN RIVGFRPELG DPVKVSCKVQ RGDENDIRSI SYYPESASFD LRYYPYYGKL
THVNYTSPLV AMHFTDVVKN QAVPVQCQLK GKGIINDVIN DRFVGRVIFT LNIET
