AT21C_ARATH
ID AT21C_ARATH Reviewed; 366 AA.
AC P0CH03; F4IJ52; Q3EBF2;
DT 10-AUG-2010, integrated into UniProtKB/Swiss-Prot.
DT 10-AUG-2010, sequence version 1.
DT 25-MAY-2022, entry version 59.
DE RecName: Full=Putative RING-H2 finger protein ATL21C;
DE EC=2.3.2.27 {ECO:0000305};
DE AltName: Full=RING-type E3 ubiquitin transferase ATL21C {ECO:0000305};
DE Flags: Precursor;
GN Name=ATL21C; OrderedLocusNames=At2g46493; ORFNames=F11C10, F13A10;
OS Arabidopsis thaliana (Mouse-ear cress).
OC Eukaryota; Viridiplantae; Streptophyta; Embryophyta; Tracheophyta;
OC Spermatophyta; Magnoliopsida; eudicotyledons; Gunneridae; Pentapetalae;
OC rosids; malvids; Brassicales; Brassicaceae; Camelineae; Arabidopsis.
OX NCBI_TaxID=3702;
RN [1]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=cv. Columbia;
RX PubMed=10617197; DOI=10.1038/45471;
RA Lin X., Kaul S., Rounsley S.D., Shea T.P., Benito M.-I., Town C.D.,
RA Fujii C.Y., Mason T.M., Bowman C.L., Barnstead M.E., Feldblyum T.V.,
RA Buell C.R., Ketchum K.A., Lee J.J., Ronning C.M., Koo H.L., Moffat K.S.,
RA Cronin L.A., Shen M., Pai G., Van Aken S., Umayam L., Tallon L.J.,
RA Gill J.E., Adams M.D., Carrera A.J., Creasy T.H., Goodman H.M.,
RA Somerville C.R., Copenhaver G.P., Preuss D., Nierman W.C., White O.,
RA Eisen J.A., Salzberg S.L., Fraser C.M., Venter J.C.;
RT "Sequence and analysis of chromosome 2 of the plant Arabidopsis thaliana.";
RL Nature 402:761-768(1999).
RN [2]
RP GENOME REANNOTATION.
RC STRAIN=cv. Columbia;
RX PubMed=27862469; DOI=10.1111/tpj.13415;
RA Cheng C.Y., Krishnakumar V., Chan A.P., Thibaud-Nissen F., Schobel S.,
RA Town C.D.;
RT "Araport11: a complete reannotation of the Arabidopsis thaliana reference
RT genome.";
RL Plant J. 89:789-804(2017).
RN [3]
RP GENE FAMILY ORGANIZATION.
RX PubMed=11983057; DOI=10.1186/gb-2002-3-4-research0016;
RA Kosarev P., Mayer K.F.X., Hardtke C.S.;
RT "Evaluation and classification of RING-finger domains encoded by the
RT Arabidopsis genome.";
RL Genome Biol. 3:RESEARCH0016.1-RESEARCH0016.12(2002).
RN [4]
RP NOMENCLATURE, AND GENE FAMILY ORGANIZATION.
RX PubMed=16557337; DOI=10.1007/s00239-005-0038-y;
RA Serrano M., Parra S., Alcaraz L.D., Guzman P.;
RT "The ATL gene family from Arabidopsis thaliana and Oryza sativa comprises a
RT large number of putative ubiquitin ligases of the RING-H2 type.";
RL J. Mol. Evol. 62:434-445(2006).
CC -!- CATALYTIC ACTIVITY:
CC Reaction=S-ubiquitinyl-[E2 ubiquitin-conjugating enzyme]-L-cysteine +
CC [acceptor protein]-L-lysine = [E2 ubiquitin-conjugating enzyme]-L-
CC cysteine + N(6)-ubiquitinyl-[acceptor protein]-L-lysine.;
CC EC=2.3.2.27; Evidence={ECO:0000305};
CC -!- PATHWAY: Protein modification; protein ubiquitination.
CC -!- SUBCELLULAR LOCATION: Membrane {ECO:0000305}; Single-pass membrane
CC protein {ECO:0000305}.
CC -!- DOMAIN: The RING-type zinc finger domain mediates binding to an E2
CC ubiquitin-conjugating enzyme. {ECO:0000250}.
CC -!- SIMILARITY: Belongs to the RING-type zinc finger family. ATL subfamily.
CC {ECO:0000305}.
CC -!- SEQUENCE CAUTION:
CC Sequence=AEC10705.1; Type=Erroneous gene model prediction; Evidence={ECO:0000305};
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DR EMBL; AC006418; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR EMBL; AC006526; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR EMBL; CP002685; AEC10705.1; ALT_SEQ; Genomic_DNA.
DR RefSeq; NP_001189760.1; NM_001202831.1.
DR AlphaFoldDB; P0CH03; -.
DR SMR; P0CH03; -.
DR PRIDE; P0CH03; -.
DR GeneID; 10723091; -.
DR KEGG; ath:AT2G46493; -.
DR Araport; AT2G46493; -.
DR TAIR; locus:6530298192; AT2G46493.
DR OrthoDB; 1487241at2759; -.
DR UniPathway; UPA00143; -.
DR PRO; PR:P0CH03; -.
DR Proteomes; UP000006548; Chromosome 2.
DR ExpressionAtlas; P0CH03; baseline and differential.
DR GO; GO:0016021; C:integral component of membrane; IEA:UniProtKB-KW.
DR GO; GO:0046872; F:metal ion binding; IEA:UniProtKB-KW.
DR GO; GO:0030247; F:polysaccharide binding; IEA:InterPro.
DR GO; GO:0016740; F:transferase activity; IEA:UniProtKB-KW.
DR GO; GO:0016567; P:protein ubiquitination; IEA:UniProtKB-UniPathway.
DR Gene3D; 3.30.40.10; -; 1.
DR InterPro; IPR025287; WAK_GUB.
DR InterPro; IPR001841; Znf_RING.
DR InterPro; IPR013083; Znf_RING/FYVE/PHD.
DR Pfam; PF13947; GUB_WAK_bind; 1.
DR Pfam; PF13639; zf-RING_2; 1.
DR SMART; SM00184; RING; 1.
DR PROSITE; PS50089; ZF_RING_2; 1.
PE 3: Inferred from homology;
KW Membrane; Metal-binding; Reference proteome; Signal; Transferase;
KW Transmembrane; Transmembrane helix; Ubl conjugation pathway; Zinc;
KW Zinc-finger.
FT SIGNAL 1..23
FT /evidence="ECO:0000255"
FT CHAIN 24..366
FT /note="Putative RING-H2 finger protein ATL21C"
FT /id="PRO_0000396122"
FT TRANSMEM 243..263
FT /note="Helical"
FT /evidence="ECO:0000255"
FT ZN_FING 320..362
FT /note="RING-type; atypical"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00175"
SQ SEQUENCE 366 AA; 41121 MW; 15E73B5909F7FDE0 CRC64;
MTFSKQLFPF VFFLLFLVSL RHASNPNNCS SSSSRPLRCG PLEVPIRFPF CNHARFNLHC
TDLNKTVLEL PMSGTFLVRD IDYRRQKIYI NDPNCLAKRL LTFNISGSPF SPHFDILYTF
LSCPNEVVLP SWYPSIPCLS NSTSSFFATS NYSLAQSMLP SCQIVKRLHV PATSPFGETR
FSSDLNNQSL LLEWALPDCR AKCLGATKKT GTIYNSNIFS CSFSFLYDSR ELFINGNLSS
GVLVLVISLS AVTVFVFPTC IAIRLYDSER FDSAIAAATV MQQPREVMAR RGLDQSTIET
FKKMELGESR RLSGTNGIVC PICLSEYASK ETVRFIPECD HCFHVECIDV WLKIHGSCPL
CRNSCA
