AT221_ASPTN
ID AT221_ASPTN Reviewed; 610 AA.
AC Q0CEJ5;
DT 05-FEB-2008, integrated into UniProtKB/Swiss-Prot.
DT 05-FEB-2008, sequence version 2.
DT 25-MAY-2022, entry version 58.
DE RecName: Full=Autophagy-related protein 22-1;
GN Name=atg22-1; ORFNames=ATEG_07889;
OS Aspergillus terreus (strain NIH 2624 / FGSC A1156).
OC Eukaryota; Fungi; Dikarya; Ascomycota; Pezizomycotina; Eurotiomycetes;
OC Eurotiomycetidae; Eurotiales; Aspergillaceae; Aspergillus;
OC Aspergillus subgen. Circumdati.
OX NCBI_TaxID=341663;
RN [1]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=NIH 2624 / FGSC A1156;
RA Birren B.W., Lander E.S., Galagan J.E., Nusbaum C., Devon K., Henn M.,
RA Ma L.-J., Jaffe D.B., Butler J., Alvarez P., Gnerre S., Grabherr M.,
RA Kleber M., Mauceli E.W., Brockman W., Rounsley S., Young S.K., LaButti K.,
RA Pushparaj V., DeCaprio D., Crawford M., Koehrsen M., Engels R.,
RA Montgomery P., Pearson M., Howarth C., Larson L., Luoma S., White J.,
RA Alvarado L., Kodira C.D., Zeng Q., Oleary S., Yandava C., Denning D.W.,
RA Nierman W.C., Milne T., Madden K.;
RT "Annotation of the Aspergillus terreus NIH2624 genome.";
RL Submitted (SEP-2005) to the EMBL/GenBank/DDBJ databases.
CC -!- FUNCTION: Vacuolar effluxer which mediate the efflux of amino acids
CC resulting from autophagic degradation. The release of autophagic amino
CC acids allows the maintenance of protein synthesis and viability during
CC nitrogen starvation (By similarity). {ECO:0000250}.
CC -!- SUBCELLULAR LOCATION: Vacuole membrane {ECO:0000250}; Multi-pass
CC membrane protein {ECO:0000250}. Note=Vacuole and punctate structures.
CC {ECO:0000250}.
CC -!- SIMILARITY: Belongs to the ATG22 family. {ECO:0000305}.
CC -!- SEQUENCE CAUTION:
CC Sequence=EAU32151.1; Type=Erroneous gene model prediction; Evidence={ECO:0000305};
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DR EMBL; CH476604; EAU32151.1; ALT_SEQ; Genomic_DNA.
DR RefSeq; XP_001216510.1; XM_001216510.1.
DR AlphaFoldDB; Q0CEJ5; -.
DR EnsemblFungi; EAU32151; EAU32151; ATEG_07889.
DR GeneID; 4322719; -.
DR eggNOG; ENOG502QVD3; Eukaryota.
DR OrthoDB; 1460747at2759; -.
DR Proteomes; UP000007963; Unassembled WGS sequence.
DR GO; GO:0016021; C:integral component of membrane; IEA:UniProtKB-KW.
DR GO; GO:0005774; C:vacuolar membrane; IEA:UniProtKB-SubCell.
DR GO; GO:0032974; P:amino acid transmembrane export from vacuole; IEA:InterPro.
DR GO; GO:0006914; P:autophagy; IEA:UniProtKB-KW.
DR CDD; cd17483; MFS_Atg22_like; 1.
DR Gene3D; 1.20.1250.20; -; 1.
DR InterPro; IPR044738; Atg22.
DR InterPro; IPR024671; Atg22-like.
DR InterPro; IPR036259; MFS_trans_sf.
DR Pfam; PF11700; ATG22; 1.
DR SUPFAM; SSF103473; SSF103473; 2.
PE 3: Inferred from homology;
KW Amino-acid transport; Autophagy; Glycoprotein; Membrane;
KW Reference proteome; Transmembrane; Transmembrane helix; Transport; Vacuole.
FT CHAIN 1..610
FT /note="Autophagy-related protein 22-1"
FT /id="PRO_0000318020"
FT TRANSMEM 35..55
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TRANSMEM 120..140
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TRANSMEM 152..171
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TRANSMEM 189..209
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TRANSMEM 278..298
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TRANSMEM 310..330
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TRANSMEM 384..404
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TRANSMEM 418..438
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TRANSMEM 453..473
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TRANSMEM 488..510
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TRANSMEM 522..544
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TRANSMEM 553..573
FT /note="Helical"
FT /evidence="ECO:0000255"
FT REGION 1..29
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 229..265
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 588..610
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT CARBOHYD 90
FT /note="N-linked (GlcNAc...) asparagine"
FT /evidence="ECO:0000255"
FT CARBOHYD 261
FT /note="N-linked (GlcNAc...) asparagine"
FT /evidence="ECO:0000255"
SQ SEQUENCE 610 AA; 65660 MW; 4A9D710281E2962B CRC64;
MAFTPSSPPS PAADASQRPS RYPGEDTTPT SRREILGWYA YGIAAEVFAV CGVGSFLPLT
LEQLARERGV LKSSHLPCVG PDAPTSSLAN GTAPALLRRD GADNDQCVVG LLGLEINTAS
FAMYTFSLAV LVQALTLISF SALADYENNR KTLLLAFGFI GSATSMLFVF VAPPVFTFGA
ILVIIGVTCL GSSFVVLNSF LPVLVANDPS IQGASKEADE ELHTLNENGQ FEPRDSFSER
NPEFESQYTP GIGLGSKPST NATSPELQLS TRISSKGVGL GYCAAVLVQI LSIGLLFALS
KTSLPKVSGT LPLRFVLLLV GIWWFSFTMV TRRWLRNRPG PPLSTTTTGG HTNKWRVWLR
LVGFAWKSLW KTVKIAVQLR EVRVFLVAWF LLSDAIATVS GTAILFARTE LKMSTTLVGC
LSITATLSGM TGAFLWPVVS RRFKLKSSHT IMLCIALFEI IPLYGMLAYI PLFKKWGVIG
LQQPWEIFPL AIVHGIVSGG LSSYCRSFFG LLIPPGSEAA FYALYAATDK GSSVIGPAIV
GMLIDATGQV RSGFFFIAIL IVLPIPLVWM VNAEKGRMEG VAMAERMAKG QESETGEPGE
EAEGLLARGA
