ID   PNRC1_RAT               Reviewed;         296 AA.
AC   Q63647;
DT   29-MAR-2005, integrated into UniProtKB/Swiss-Prot.
DT   29-MAR-2005, sequence version 2.
DT   25-MAY-2022, entry version 93.
DE   RecName: Full=Proline-rich nuclear receptor coactivator 1;
DE   AltName: Full=Proline-rich protein 2;
GN   Name=Pnrc1; Synonyms=Prol2;
OS   Rattus norvegicus (Rat).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC   Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae;
OC   Murinae; Rattus.
OX   NCBI_TaxID=10116;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [MRNA].
RC   STRAIN=Sprague-Dawley; TISSUE=Bronchiolar epithelial cell;
RX   PubMed=8780705; DOI=10.1006/bbrc.1996.1266;
RA   Bingle C.D.;
RT   "Generation of a rat bronchiolar epithelial cell cDNA library: isolation of
RT   a proline rich protein highly enriched in bronchiolar epithelial cells.";
RL   Biochem. Biophys. Res. Commun. 225:877-882(1996).
CC   -!- FUNCTION: Nuclear receptor coactivator. May play a role in signal
CC       transduction (By similarity). {ECO:0000250}.
CC   -!- SUBUNIT: Interacts with many nuclear receptors including AR, ESR1,
CC       ESRRA, ESRRG, NR3C1/GR, NR5A1, PGR, TR, RAR and RXR. Interacts with
CC       GRB2 (By similarity). {ECO:0000250}.
CC   -!- SUBCELLULAR LOCATION: Nucleus {ECO:0000250}.
CC   -!- DOMAIN: The interaction between PNRC1 and nuclear receptors is
CC       dependent on the SH3 binding motif.
CC   -!- SIMILARITY: Belongs to the PNRC family. PNRC1 subfamily. {ECO:0000305}.
CC   -!- SEQUENCE CAUTION:
CC       Sequence=AAB09057.1; Type=Frameshift; Evidence={ECO:0000305};
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DR   EMBL; U61729; AAB09057.1; ALT_FRAME; mRNA.
DR   PIR; JC4899; JC4899.
DR   RefSeq; NP_775444.1; NM_173322.1.
DR   AlphaFoldDB; Q63647; -.
DR   SMR; Q63647; -.
DR   STRING; 10116.ENSRNOP00000010271; -.
DR   PhosphoSitePlus; Q63647; -.
DR   PaxDb; Q63647; -.
DR   GeneID; 286988; -.
DR   KEGG; rno:286988; -.
DR   UCSC; RGD:628753; rat.
DR   CTD; 10957; -.
DR   RGD; 628753; Pnrc1.
DR   eggNOG; ENOG502RYBG; Eukaryota.
DR   InParanoid; Q63647; -.
DR   OrthoDB; 1030659at2759; -.
DR   PhylomeDB; Q63647; -.
DR   TreeFam; TF333211; -.
DR   PRO; PR:Q63647; -.
DR   Proteomes; UP000002494; Unplaced.
DR   GO; GO:0005634; C:nucleus; IBA:GO_Central.
DR   InterPro; IPR026780; PNRC1/2.
DR   PANTHER; PTHR15405; PTHR15405; 1.
PE   2: Evidence at transcript level;
KW   Activator; Nucleus; Reference proteome; Transcription;
KW   Transcription regulation.
FT   CHAIN           1..296
FT                   /note="Proline-rich nuclear receptor coactivator 1"
FT                   /id="PRO_0000058483"
FT   REGION          78..132
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   REGION          202..234
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   REGION          248..280
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   MOTIF           85..92
FT                   /note="Nuclear localization signal"
FT                   /evidence="ECO:0000250"
FT   MOTIF           254..260
FT                   /note="SH3-binding"
FT   COMPBIAS        212..230
FT                   /note="Basic and acidic residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ   SEQUENCE   296 AA;  32374 MW;  D9AD641E6605B05B CRC64;
     MTVVSVPQRD LALGGRLAPL GSLGALPMVS PAPPPLPRLP DPRALPPTLF LPHFLGGDGP
     CLARASHRCT VQLQLGPGRC PTAAPKKRRK KKVRASPAGQ LPSRFHQFQQ HRPSLEGGRS
     PVPGPIAAQE ERGPGATALL YRQPPLAKEV LKSKMGKSEK ISPPHSQLVH GIHLCEQPKI
     SRQKSKFNLP LTKITSAKRN ENDFWQDSAS SDRMQKQEKK PLKNTENIKN NHLKKSAFLT
     EGSQKENYAG AKFSDPPSPS VLPKPPSHWM GSTTENPSQS RELMAVHLKT LLKVQT