PNRC2_DANRE
ID PNRC2_DANRE Reviewed; 148 AA.
AC B7TWP7;
DT 16-JUN-2009, integrated into UniProtKB/Swiss-Prot.
DT 16-JUN-2009, sequence version 2.
DT 03-AUG-2022, entry version 66.
DE RecName: Full=Proline-rich nuclear receptor coactivator 2;
GN Name=pnrc2;
OS Danio rerio (Zebrafish) (Brachydanio rerio).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC Actinopterygii; Neopterygii; Teleostei; Ostariophysi; Cypriniformes;
OC Danionidae; Danioninae; Danio.
OX NCBI_TaxID=7955;
RN [1]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
RC TISSUE=Embryo;
RG NIH - Zebrafish Gene Collection (ZGC) project;
RL Submitted (MAR-2008) to the EMBL/GenBank/DDBJ databases.
RN [2]
RP NUCLEOTIDE SEQUENCE [MRNA] OF 84-148.
RX PubMed=19166982; DOI=10.1016/j.gep.2008.12.007;
RA Toro S., Wegner J., Muller M., Westerfield M., Varga Z.M.;
RT "Identification of differentially expressed genes in the zebrafish
RT hypothalamic-pituitary axis.";
RL Gene Expr. Patterns 9:200-208(2009).
CC -!- FUNCTION: Involved in nonsense-mediated mRNA decay (NMD) by acting as a
CC bridge between the mRNA decapping complex and the NMD machinery. May
CC act by targeting the NMD machinery to the P-body and recruiting the
CC decapping machinery to aberrant mRNAs. Required for upf1/rent1
CC localization to the P-body. Also acts as a nuclear receptor coactivator
CC (By similarity). {ECO:0000250}.
CC -!- SUBCELLULAR LOCATION: Nucleus {ECO:0000250}. Cytoplasm, P-body
CC {ECO:0000250}.
CC -!- SIMILARITY: Belongs to the PNRC family. PNRC2 subfamily. {ECO:0000305}.
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DR EMBL; BC160613; -; NOT_ANNOTATED_CDS; mRNA.
DR EMBL; FJ392617; ACJ64071.1; -; mRNA.
DR RefSeq; NP_001123664.1; NM_001130192.1.
DR AlphaFoldDB; B7TWP7; -.
DR SMR; B7TWP7; -.
DR STRING; 7955.ENSDARP00000113947; -.
DR PaxDb; B7TWP7; -.
DR PRIDE; B7TWP7; -.
DR Ensembl; ENSDART00000145055; ENSDARP00000113947; ENSDARG00000053291.
DR Ensembl; ENSDART00000190354; ENSDARP00000152312; ENSDARG00000112537.
DR GeneID; 565522; -.
DR KEGG; dre:565522; -.
DR CTD; 55629; -.
DR ZFIN; ZDB-GENE-030131-5475; pnrc2.
DR eggNOG; ENOG502RZZX; Eukaryota.
DR GeneTree; ENSGT00530000063881; -.
DR HOGENOM; CLU_086541_1_0_1; -.
DR InParanoid; B7TWP7; -.
DR OMA; HREAMAF; -.
DR OrthoDB; 1570409at2759; -.
DR PhylomeDB; B7TWP7; -.
DR Reactome; R-DRE-975957; Nonsense Mediated Decay (NMD) enhanced by the Exon Junction Complex (EJC).
DR PRO; PR:B7TWP7; -.
DR Proteomes; UP000000437; Genome assembly.
DR Proteomes; UP000814640; Chromosome 16.
DR Bgee; ENSDARG00000053291; Expressed in cardiac ventricle and 26 other tissues.
DR ExpressionAtlas; B7TWP7; baseline and differential.
DR GO; GO:0005634; C:nucleus; ISS:UniProtKB.
DR GO; GO:0000932; C:P-body; ISS:UniProtKB.
DR GO; GO:0000956; P:nuclear-transcribed mRNA catabolic process; IMP:ZFIN.
DR GO; GO:0000184; P:nuclear-transcribed mRNA catabolic process, nonsense-mediated decay; ISS:UniProtKB.
DR InterPro; IPR026780; PNRC1/2.
DR InterPro; IPR026781; PNRC2.
DR PANTHER; PTHR15405; PTHR15405; 1.
DR PANTHER; PTHR15405:SF6; PTHR15405:SF6; 1.
PE 2: Evidence at transcript level;
KW Activator; Cytoplasm; Nonsense-mediated mRNA decay; Nucleus;
KW Reference proteome; Transcription; Transcription regulation.
FT CHAIN 1..148
FT /note="Proline-rich nuclear receptor coactivator 2"
FT /id="PRO_0000377564"
FT REGION 1..69
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT MOTIF 109..115
FT /note="SH3-binding"
FT CONFLICT 88
FT /note="E -> G (in Ref. 2; ACJ64071)"
FT /evidence="ECO:0000305"
SQ SEQUENCE 148 AA; 16285 MW; 6A8A355FCCFBA537 CRC64;
MGGGERYNIP DRPAPKKSQP VSRGKQRSRD QNGVMHSAAS GALGVPHHLR RGEKGTSYSW
SPEARQAVSV DKKNGSVRFA TPYDQNWESH LNKLLSAQCG QNYAGAKFSE PPSPSVLPKP
PSHWVSLPMG DHRELMTFQL KSLLKVQA
