ID   PNRC2_SALSA             Reviewed;         156 AA.
AC   B5X392;
DT   16-JUN-2009, integrated into UniProtKB/Swiss-Prot.
DT   25-NOV-2008, sequence version 1.
DT   03-AUG-2022, entry version 39.
DE   RecName: Full=Proline-rich nuclear receptor coactivator 2;
GN   Name=pnrc2;
OS   Salmo salar (Atlantic salmon).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC   Actinopterygii; Neopterygii; Teleostei; Protacanthopterygii; Salmoniformes;
OC   Salmonidae; Salmoninae; Salmo.
OX   NCBI_TaxID=8030;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
RC   TISSUE=Brain;
RX   PubMed=20433749; DOI=10.1186/1471-2164-11-279;
RA   Leong J.S., Jantzen S.G., von Schalburg K.R., Cooper G.A., Messmer A.M.,
RA   Liao N.Y., Munro S., Moore R., Holt R.A., Jones S.J., Davidson W.S.,
RA   Koop B.F.;
RT   "Salmo salar and Esox lucius full-length cDNA sequences reveal changes in
RT   evolutionary pressures on a post-tetraploidization genome.";
RL   BMC Genomics 11:279-279(2010).
CC   -!- FUNCTION: Involved in nonsense-mediated mRNA decay (NMD) by acting as a
CC       bridge between the mRNA decapping complex and the NMD machinery. May
CC       act by targeting the NMD machinery to the P-body and recruiting the
CC       decapping machinery to aberrant mRNAs. Required for upf1/rent1
CC       localization to the P-body. Also acts as a nuclear receptor coactivator
CC       (By similarity). {ECO:0000250}.
CC   -!- SUBCELLULAR LOCATION: Nucleus {ECO:0000250}. Cytoplasm, P-body
CC       {ECO:0000250}.
CC   -!- SIMILARITY: Belongs to the PNRC family. PNRC2 subfamily. {ECO:0000305}.
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DR   EMBL; BT045511; ACI33773.1; -; mRNA.
DR   RefSeq; NP_001133719.1; NM_001140247.1.
DR   RefSeq; XP_014019115.1; XM_014163640.1.
DR   AlphaFoldDB; B5X392; -.
DR   GeneID; 100195218; -.
DR   KEGG; sasa:100195218; -.
DR   CTD; 55629; -.
DR   OMA; QKTVMQN; -.
DR   OrthoDB; 1570409at2759; -.
DR   Proteomes; UP000087266; Chromosome ssa02.
DR   Bgee; ENSSSAG00000027852; Expressed in zone of skin and 16 other tissues.
DR   GO; GO:0005634; C:nucleus; ISS:UniProtKB.
DR   GO; GO:0000932; C:P-body; ISS:UniProtKB.
DR   GO; GO:0000184; P:nuclear-transcribed mRNA catabolic process, nonsense-mediated decay; ISS:UniProtKB.
DR   InterPro; IPR026780; PNRC1/2.
DR   InterPro; IPR026781; PNRC2.
DR   PANTHER; PTHR15405; PTHR15405; 1.
DR   PANTHER; PTHR15405:SF6; PTHR15405:SF6; 1.
PE   2: Evidence at transcript level;
KW   Activator; Cytoplasm; Nonsense-mediated mRNA decay; Nucleus;
KW   Reference proteome; Transcription; Transcription regulation.
FT   CHAIN           1..156
FT                   /note="Proline-rich nuclear receptor coactivator 2"
FT                   /id="PRO_0000377565"
FT   REGION          1..32
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   MOTIF           117..123
FT                   /note="SH3-binding"
SQ   SEQUENCE   156 AA;  16868 MW;  FC8176836A225E65 CRC64;
     MGGGERYNIP VSHPERPLPK KNHQLGRAKQ RVVRDQNGVT TVASSGAAGG PHQHGHRKGA
     AYPWFPEARL AASAEKKNTS VRFANAYDQN WEGAVSHLNT LLAAQCGGPS YAGAKFSEPP
     SPSVLPKPPS HWVPMGTRDS REMMAFQLKS LLKVHA