ID   PNRC2_XENTR             Reviewed;         136 AA.
AC   Q68EQ8;
DT   16-JUN-2009, integrated into UniProtKB/Swiss-Prot.
DT   11-OCT-2004, sequence version 1.
DT   03-AUG-2022, entry version 83.
DE   RecName: Full=Proline-rich nuclear receptor coactivator 2;
GN   Name=pnrc2;
OS   Xenopus tropicalis (Western clawed frog) (Silurana tropicalis).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Amphibia;
OC   Batrachia; Anura; Pipoidea; Pipidae; Xenopodinae; Xenopus; Silurana.
OX   NCBI_TaxID=8364;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
RC   TISSUE=Embryo;
RG   NIH - Xenopus Gene Collection (XGC) project;
RL   Submitted (AUG-2004) to the EMBL/GenBank/DDBJ databases.
CC   -!- FUNCTION: Involved in nonsense-mediated mRNA decay (NMD) by acting as a
CC       bridge between the mRNA decapping complex and the NMD machinery. May
CC       act by targeting the NMD machinery to the P-body and recruiting the
CC       decapping machinery to aberrant mRNAs. Required for upf1/rent1
CC       localization to the P-body. Also acts as a nuclear receptor coactivator
CC       (By similarity). {ECO:0000250}.
CC   -!- SUBCELLULAR LOCATION: Nucleus {ECO:0000250}. Cytoplasm, P-body
CC       {ECO:0000250}.
CC   -!- SIMILARITY: Belongs to the PNRC family. PNRC2 subfamily. {ECO:0000305}.
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DR   EMBL; BC080143; AAH80143.1; -; mRNA.
DR   RefSeq; NP_001008433.1; NM_001008433.1.
DR   AlphaFoldDB; Q68EQ8; -.
DR   SMR; Q68EQ8; -.
DR   STRING; 8364.ENSXETP00000034230; -.
DR   PaxDb; Q68EQ8; -.
DR   DNASU; 493263; -.
DR   GeneID; 493263; -.
DR   KEGG; xtr:493263; -.
DR   CTD; 55629; -.
DR   Xenbase; XB-GENE-490316; pnrc2.
DR   eggNOG; ENOG502RZZX; Eukaryota.
DR   HOGENOM; CLU_086541_1_0_1; -.
DR   InParanoid; Q68EQ8; -.
DR   OMA; FPASKNF; -.
DR   OrthoDB; 1570409at2759; -.
DR   PhylomeDB; Q68EQ8; -.
DR   Proteomes; UP000008143; Chromosome 2.
DR   Proteomes; UP000790000; Unplaced.
DR   ExpressionAtlas; Q68EQ8; baseline.
DR   GO; GO:0005634; C:nucleus; ISS:UniProtKB.
DR   GO; GO:0000932; C:P-body; ISS:UniProtKB.
DR   GO; GO:0000184; P:nuclear-transcribed mRNA catabolic process, nonsense-mediated decay; ISS:UniProtKB.
DR   InterPro; IPR026780; PNRC1/2.
DR   InterPro; IPR026781; PNRC2.
DR   PANTHER; PTHR15405; PTHR15405; 1.
DR   PANTHER; PTHR15405:SF6; PTHR15405:SF6; 1.
PE   2: Evidence at transcript level;
KW   Activator; Cytoplasm; Nonsense-mediated mRNA decay; Nucleus;
KW   Reference proteome; Transcription; Transcription regulation.
FT   CHAIN           1..136
FT                   /note="Proline-rich nuclear receptor coactivator 2"
FT                   /id="PRO_0000377568"
FT   REGION          1..22
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   REGION          58..78
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   MOTIF           96..102
FT                   /note="SH3-binding"
SQ   SEQUENCE   136 AA;  15161 MW;  6755DD1F8333B38E CRC64;
     MGGGERFNIP GQHRNNLGKQ INRQKLLERN NQKMNTSLSK DRVRGCGTSL AWQAMQNGVN
     NNNTRSSNQN WSAGFPASKN FFTDQDNQNY AGAKFSEPPS PSVLPKPPSH WVLLSCSPAE
     KELMSFQLKT LLKVQA