ID   PNT87_HUMAN             Reviewed;          87 AA.
AC   A0A455ZAR2;
DT   23-FEB-2022, integrated into UniProtKB/Swiss-Prot.
DT   05-JUN-2019, sequence version 1.
DT   25-MAY-2022, entry version 4.
DE   RecName: Full=Transcriptional regulator PINT87aa {ECO:0000305};
GN   Name=LINC-PINT {ECO:0000312|HGNC:HGNC:26885};
OS   Homo sapiens (Human).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC   Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae;
OC   Homo.
OX   NCBI_TaxID=9606 {ECO:0000312|EMBL:DAC74127.1};
RN   [1] {ECO:0000312|EMBL:EAW83777.1}
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RA   Mural R.J., Istrail S., Sutton G., Florea L., Halpern A.L., Mobarry C.M.,
RA   Lippert R., Walenz B., Shatkay H., Dew I., Miller J.R., Flanigan M.J.,
RA   Edwards N.J., Bolanos R., Fasulo D., Halldorsson B.V., Hannenhalli S.,
RA   Turner R., Yooseph S., Lu F., Nusskern D.R., Shue B.C., Zheng X.H.,
RA   Zhong F., Delcher A.L., Huson D.H., Kravitz S.A., Mouchard L., Reinert K.,
RA   Remington K.A., Clark A.G., Waterman M.S., Eichler E.E., Adams M.D.,
RA   Hunkapiller M.W., Myers E.W., Venter J.C.;
RL   Submitted (JUL-2005) to the EMBL/GenBank/DDBJ databases.
RN   [2] {ECO:0000312|EMBL:DAC74127.1}
RP   PROTEIN SEQUENCE OF 1-7 AND 37-56, IDENTIFICATION BY MASS SPECTROMETRY,
RP   FUNCTION, INTERACTION WITH PAF1, SUBCELLULAR LOCATION, AND TISSUE
RP   SPECIFICITY.
RX   PubMed=30367041; DOI=10.1038/s41467-018-06862-2;
RA   Zhang M., Zhao K., Xu X., Yang Y., Yan S., Wei P., Liu H., Xu J., Xiao F.,
RA   Zhou H., Yang X., Huang N., Liu J., He K., Xie K., Zhang G., Huang S.,
RA   Zhang N.;
RT   "A peptide encoded by circular form of LINC-PINT suppresses oncogenic
RT   transcriptional elongation in glioblastoma.";
RL   Nat. Commun. 9:4475-4475(2018).
RN   [3] {ECO:0000305}
RP   FUNCTION, AND INTERACTION WITH FOXM1.
RX   PubMed=33754036; DOI=10.7150/thno.55672;
RA   Xiang X., Fu Y., Zhao K., Miao R., Zhang X., Ma X., Liu C., Zhang N.,
RA   Qu K.;
RT   "Cellular senescence in hepatocellular carcinoma induced by a long non-
RT   coding RNA-encoded peptide PINT87aa by blocking FOXM1-mediated PHB2.";
RL   Theranostics 11:4929-4944(2021).
CC   -!- FUNCTION: Enhances the binding of the PAF1 complex to target gene
CC       promoters and plays a role in negative regulation of transcription
CC       (PubMed:30367041). May function as an anchor to keep the PAF1 complex
CC       on target gene promoters, sequentially pausing RNA polymerase II-
CC       induced mRNA elongation (PubMed:30367041). Inhibits FOXM1-mediated
CC       transcription of PHB2 (PubMed:33754036). {ECO:0000269|PubMed:30367041,
CC       ECO:0000269|PubMed:33754036}.
CC   -!- SUBUNIT: Interacts with PAF1 complex member PAF1 (PubMed:30367041).
CC       Interacts with transcription factor FOXM1 (PubMed:33754036).
CC       {ECO:0000269|PubMed:30367041, ECO:0000269|PubMed:33754036}.
CC   -!- INTERACTION:
CC       A0A455ZAR2; Q08050: FOXM1; NbExp=4; IntAct=EBI-27121529, EBI-866480;
CC       A0A455ZAR2; Q8N7H5: PAF1; NbExp=5; IntAct=EBI-27121529, EBI-2607770;
CC   -!- SUBCELLULAR LOCATION: Nucleus {ECO:0000269|PubMed:30367041}.
CC   -!- TISSUE SPECIFICITY: Expressed in brain, liver, kidney and stomach with
CC       lower levels in breast, intestine, thyroid and pancreas.
CC       {ECO:0000269|PubMed:30367041}.
CC   -!- MISCELLANEOUS: Encoded by the circular form of the long non-coding RNA
CC       LINC-PINT. {ECO:0000269|PubMed:30367041}.
CC   -!- MISCELLANEOUS: Suppresses glioblastoma cell proliferation and shows
CC       decreased expression in glioblastomas compared to normal non-tumor
CC       brain tissue (PubMed:30367041). Induces growth inhibition and cellular
CC       sensescence and decreases mitophagy in hepatocellular carcinoma (HCC)
CC       cells with higher levels of expression in non-tumor tissue than in
CC       adjacent HCC tissue (PubMed:33754036). {ECO:0000269|PubMed:30367041,
CC       ECO:0000269|PubMed:33754036}.
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DR   EMBL; CH471070; EAW83777.1; -; Genomic_DNA.
DR   EMBL; BK010446; DAC74127.1; -; Genomic_RNA.
DR   IntAct; A0A455ZAR2; 10.
DR   HGNC; HGNC:26885; LINC-PINT.
DR   Proteomes; UP000005640; Unplaced.
DR   GO; GO:0005634; C:nucleus; IDA:UniProtKB.
DR   GO; GO:0000122; P:negative regulation of transcription by RNA polymerase II; IMP:UniProtKB.
PE   1: Evidence at protein level;
KW   Direct protein sequencing; Nucleus; Reference proteome; Transcription;
KW   Transcription regulation.
FT   CHAIN           1..87
FT                   /note="Transcriptional regulator PINT87aa"
FT                   /id="PRO_0000454938"
SQ   SEQUENCE   87 AA;  9607 MW;  061E65717CFB8CB2 CRC64;
     MLWLPDRGSC SARSPSGMLR GAPGGWRYGR RCGRRRQSCC CCCCCSHVGA PLSFHREASL
     VSHDGHDIMK QHCGEESIRG AHGYKNK