ID   PO11_BRACO              Reviewed;        1004 AA.
AC   Q03277;
DT   01-JUN-1994, integrated into UniProtKB/Swiss-Prot.
DT   01-JUN-1994, sequence version 1.
DT   25-MAY-2022, entry version 72.
DE   RecName: Full=Retrovirus-related Pol polyprotein from type-1 retrotransposable element R1;
DE   AltName: Full=Retrovirus-related Pol polyprotein from type I retrotransposable element R1;
DE   Includes:
DE     RecName: Full=Reverse transcriptase;
DE              EC=2.7.7.49;
DE   Includes:
DE     RecName: Full=Endonuclease;
DE   Flags: Fragment;
OS   Bradysia coprophila (Dark-winged fungus gnat) (Sciara coprophila).
OC   Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Hexapoda; Insecta; Pterygota;
OC   Neoptera; Endopterygota; Diptera; Nematocera; Sciaroidea; Sciaridae;
OC   Bradysia.
OX   NCBI_TaxID=38358;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [GENOMIC DNA].
RX   PubMed=8383793; DOI=10.1093/oxfordjournals.molbev.a039990;
RA   Burke W.D., Eickbush D.G., Xiong Y., Jakubczak J.L., Eickbush T.H.;
RT   "Sequence relationship of retrotransposable elements R1 and R2 within and
RT   between divergent insect species.";
RL   Mol. Biol. Evol. 10:163-185(1993).
CC   -!- CATALYTIC ACTIVITY:
CC       Reaction=a 2'-deoxyribonucleoside 5'-triphosphate + DNA(n) =
CC         diphosphate + DNA(n+1); Xref=Rhea:RHEA:22508, Rhea:RHEA-COMP:17339,
CC         Rhea:RHEA-COMP:17340, ChEBI:CHEBI:33019, ChEBI:CHEBI:61560,
CC         ChEBI:CHEBI:173112; EC=2.7.7.49; Evidence={ECO:0000255|PROSITE-
CC         ProRule:PRU00405};
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DR   EMBL; L00945; AAA29813.1; -; Genomic_DNA.
DR   PIR; A44490; A44490.
DR   AlphaFoldDB; Q03277; -.
DR   SMR; Q03277; -.
DR   GO; GO:0004519; F:endonuclease activity; IEA:UniProtKB-KW.
DR   GO; GO:0003964; F:RNA-directed DNA polymerase activity; IEA:UniProtKB-KW.
DR   Gene3D; 3.60.10.10; -; 1.
DR   InterPro; IPR043502; DNA/RNA_pol_sf.
DR   InterPro; IPR036691; Endo/exonu/phosph_ase_sf.
DR   InterPro; IPR005135; Endo/exonuclease/phosphatase.
DR   InterPro; IPR000477; RT_dom.
DR   Pfam; PF14529; Exo_endo_phos_2; 1.
DR   Pfam; PF00078; RVT_1; 1.
DR   SUPFAM; SSF56219; SSF56219; 1.
DR   SUPFAM; SSF56672; SSF56672; 1.
DR   PROSITE; PS50878; RT_POL; 1.
PE   4: Predicted;
KW   Endonuclease; Hydrolase; Nuclease; Nucleotidyltransferase;
KW   RNA-directed DNA polymerase; Transferase; Transposable element.
FT   CHAIN           <1..1004
FT                   /note="Retrovirus-related Pol polyprotein from type-1
FT                   retrotransposable element R1"
FT                   /id="PRO_0000058493"
FT   DOMAIN          450..717
FT                   /note="Reverse transcriptase"
FT                   /evidence="ECO:0000255|PROSITE-ProRule:PRU00405"
FT   REGION          853..1004
FT                   /note="Nucleic acid-binding endonuclease"
FT   NON_TER         1
SQ   SEQUENCE   1004 AA;  113434 MW;  70A116B78245388A CRC64;
     LRGEVRGLPS SFRVVTSRIV NDGIGISAIV INDPEADVLV IEDCTDEYGV CVLIKGATCS
     MYVVSVYCRF GTALGPYLQY MENVRVKCGN TYMIMGMDAN AVSPLWFSKG ENLGRGRLNE
     ANGLLLEEWI LEGRMIVINE PSEWYTFSGP NGSSDIDVTL VNEAGGRFGY EWSVQPEWGV
     SDHNLIRIRV SLDGLVADAS PSPQSARWQT RDTDWGEYMG DVKAKADVFG LAQYENVSVD
     EKVDLLTEWI YGANDWNMRR HTAVRTFQNE WWSVELAEKR SELRRRRHAF QRIRNAGAAS
     LADRLQAFRD CKIEYKRMLC EAKLRCWQEF VASESNENPW GRVFKLCRGR RKPVDVCSVK
     VDGVYTDTWE GSVNAMMNVF FPASIDDASE IDRLKAIARP LPPDLEMDEV SDSVRRCKVR
     KSPGPDGIVG EMVRAVWGAI PEYMFCLYKQ CLLESYFPQK WKIASLVILL KLLDRIRSDP
     GSYRPICLLD NLGKVLEGIM VKRLDQKLMD VEVSPYQFAF TYGKSTEDAW RCVQRHVECS
     EMKYVIGLNI DFQGAFDNLG WLSMLLKLDE AQSNEFGLWM SYFGGRKVYY VGKTGIVRKD
     VTRGCPQGSK SGPAMWKLVM NELLLALVAA GFFIVAFADD GTIVIGANSR SALEELGTRC
     LQLCHEWGKR VCVPVSAGKT TCILMKGHLS ANRPPCIRLN GTSISYKSEV KHLGIFVAER
     MNFRPHFVYL RGKILGLVGC LRRVMRKSWG LGRRATCILY KGLFVACMSY GASVWFRTLR
     FSYASILLNR CQRLVLYASL NVCRTVSTER MQVLHGELPW DLEATRRGLL SEFRKGITPV
     DGDPITDEEM LGLSGSQFKE LLMERLLDVW QGRWDVSEKG RLTHEFIPSV RFVRENEWMA
     FGLCLGYVLT GHGSMNGFLH KRGLSNTPVC MCGAPNEDVK HLLGECPLYE DLRDLNGCGL
     LIRNGSLDVS GALSEIGAFE KLNQFAVSLF GRRSRLMRGM RIRE