ID   PO11_NASVI              Reviewed;         337 AA.
AC   Q03269;
DT   01-JUN-1994, integrated into UniProtKB/Swiss-Prot.
DT   01-JUN-1994, sequence version 1.
DT   25-MAY-2022, entry version 73.
DE   RecName: Full=Retrovirus-related Pol polyprotein from type-1 retrotransposable element R1;
DE   AltName: Full=Retrovirus-related Pol polyprotein from type I retrotransposable element R1;
DE   Includes:
DE     RecName: Full=Reverse transcriptase;
DE              EC=2.7.7.49;
DE   Includes:
DE     RecName: Full=Endonuclease;
DE   Flags: Fragment;
OS   Nasonia vitripennis (Parasitic wasp).
OC   Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Hexapoda; Insecta; Pterygota;
OC   Neoptera; Endopterygota; Hymenoptera; Apocrita; Parasitoida; Chalcidoidea;
OC   Pteromalidae; Pteromalinae; Nasonia.
OX   NCBI_TaxID=7425;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [GENOMIC DNA].
RX   PubMed=8383793; DOI=10.1093/oxfordjournals.molbev.a039990;
RA   Burke W.D., Eickbush D.G., Xiong Y., Jakubczak J.L., Eickbush T.H.;
RT   "Sequence relationship of retrotransposable elements R1 and R2 within and
RT   between divergent insect species.";
RL   Mol. Biol. Evol. 10:163-185(1993).
CC   -!- CATALYTIC ACTIVITY:
CC       Reaction=a 2'-deoxyribonucleoside 5'-triphosphate + DNA(n) =
CC         diphosphate + DNA(n+1); Xref=Rhea:RHEA:22508, Rhea:RHEA-COMP:17339,
CC         Rhea:RHEA-COMP:17340, ChEBI:CHEBI:33019, ChEBI:CHEBI:61560,
CC         ChEBI:CHEBI:173112; EC=2.7.7.49; Evidence={ECO:0000255|PROSITE-
CC         ProRule:PRU00405};
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DR   EMBL; L00940; AAA30337.1; -; Genomic_DNA.
DR   PIR; B44490; B44490.
DR   AlphaFoldDB; Q03269; -.
DR   PRIDE; Q03269; -.
DR   Proteomes; UP000002358; Unplaced.
DR   GO; GO:0004519; F:endonuclease activity; IEA:UniProtKB-KW.
DR   GO; GO:0003964; F:RNA-directed DNA polymerase activity; IEA:UniProtKB-KW.
DR   InterPro; IPR043502; DNA/RNA_pol_sf.
DR   InterPro; IPR000477; RT_dom.
DR   Pfam; PF00078; RVT_1; 1.
DR   SUPFAM; SSF56672; SSF56672; 1.
DR   PROSITE; PS50878; RT_POL; 1.
PE   4: Predicted;
KW   Endonuclease; Hydrolase; Nuclease; Nucleotidyltransferase;
KW   Reference proteome; RNA-directed DNA polymerase; Transferase;
KW   Transposable element.
FT   CHAIN           <1..337
FT                   /note="Retrovirus-related Pol polyprotein from type-1
FT                   retrotransposable element R1"
FT                   /id="PRO_0000058491"
FT   DOMAIN          <1..118
FT                   /note="Reverse transcriptase"
FT                   /evidence="ECO:0000255|PROSITE-ProRule:PRU00405"
FT   REGION          253..337
FT                   /note="Nucleic acid-binding endonuclease"
FT   NON_TER         1
SQ   SEQUENCE   337 AA;  38330 MW;  7961F6A27A0A9788 CRC64;
     GCPQGSISGP YMWNLCMNGL LDRLSAMNER IVAYADDLMI VANGNSRMEM ERMADECMRI
     VYEWGREVGV SISEKKTVCI MLKGKLNVDG RRMRVAVAEG TISSIGYVKS ARYLGVCMGE
     RMSFADDIRG LITKVMGAIG GLRRVMRKEW GVKKKTAYTW AKGLLLAGVM YGSSVWYEGM
     KYKTMRESMN SIQRCAMYAC LRVCRTVSTE AMQVLLGWLP CDLECVKDKC VQGSAWHRND
     ESDLVTDAEI AEKRARSCKL MKEREHEIWQ RRWCESTKGR VMHEWLCDVN FACERMWFEP
     SLRVGYILTG HGTLNAWLYD RDPLDSAACP CGAPRED