ID   PO11_POPJA              Reviewed;         245 AA.
AC   Q03276;
DT   01-JUN-1994, integrated into UniProtKB/Swiss-Prot.
DT   01-JUN-1994, sequence version 1.
DT   25-MAY-2022, entry version 69.
DE   RecName: Full=Retrovirus-related Pol polyprotein from type-1 retrotransposable element R1;
DE   AltName: Full=Retrovirus-related Pol polyprotein from type I retrotransposable element R1;
DE   Includes:
DE     RecName: Full=Reverse transcriptase;
DE              EC=2.7.7.49;
DE   Includes:
DE     RecName: Full=Endonuclease;
DE   Flags: Fragment;
OS   Popillia japonica (Japanese beetle).
OC   Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Hexapoda; Insecta; Pterygota;
OC   Neoptera; Endopterygota; Coleoptera; Polyphaga; Scarabaeiformia;
OC   Scarabaeidae; Rutelinae; Popillia.
OX   NCBI_TaxID=7064;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [GENOMIC DNA].
RX   PubMed=8383793; DOI=10.1093/oxfordjournals.molbev.a039990;
RA   Burke W.D., Eickbush D.G., Xiong Y., Jakubczak J.L., Eickbush T.H.;
RT   "Sequence relationship of retrotransposable elements R1 and R2 within and
RT   between divergent insect species.";
RL   Mol. Biol. Evol. 10:163-185(1993).
RN   [2]
RP   NUCLEOTIDE SEQUENCE [GENOMIC DNA] OF 175-191.
RX   PubMed=1849649; DOI=10.1073/pnas.88.8.3295;
RA   Jakubczak J.L., Burke W.D., Eickbush T.H.;
RT   "Retrotransposable elements R1 and R2 interrupt the rRNA genes of most
RT   insects.";
RL   Proc. Natl. Acad. Sci. U.S.A. 88:3295-3299(1991).
CC   -!- CATALYTIC ACTIVITY:
CC       Reaction=a 2'-deoxyribonucleoside 5'-triphosphate + DNA(n) =
CC         diphosphate + DNA(n+1); Xref=Rhea:RHEA:22508, Rhea:RHEA-COMP:17339,
CC         Rhea:RHEA-COMP:17340, ChEBI:CHEBI:33019, ChEBI:CHEBI:61560,
CC         ChEBI:CHEBI:173112; EC=2.7.7.49;
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DR   EMBL; L00944; AAA29783.1; -; Genomic_DNA.
DR   PIR; F44490; F44490.
DR   AlphaFoldDB; Q03276; -.
DR   SMR; Q03276; -.
DR   GO; GO:0004519; F:endonuclease activity; IEA:UniProtKB-KW.
DR   GO; GO:0003676; F:nucleic acid binding; IEA:InterPro.
DR   GO; GO:0003964; F:RNA-directed DNA polymerase activity; IEA:UniProtKB-KW.
DR   Gene3D; 3.30.420.10; -; 1.
DR   InterPro; IPR012337; RNaseH-like_sf.
DR   InterPro; IPR036397; RNaseH_sf.
DR   SUPFAM; SSF53098; SSF53098; 1.
PE   4: Predicted;
KW   Endonuclease; Hydrolase; Nuclease; Nucleotidyltransferase;
KW   RNA-directed DNA polymerase; Transferase; Transposable element.
FT   CHAIN           <1..245
FT                   /note="Retrovirus-related Pol polyprotein from type-1
FT                   retrotransposable element R1"
FT                   /id="PRO_0000058492"
FT   DOMAIN          <1..105
FT                   /note="Reverse transcriptase"
FT   REGION          106..245
FT                   /note="Nucleic acid-binding endonuclease"
FT   NON_TER         1
SQ   SEQUENCE   245 AA;  28406 MW;  44D5C5C55E0D6166 CRC64;
     LKDGTGIVAA ELVAIEKGCE ELLSRRKSGW IVTDSEGAIG ALRKWKSEDR VTQDIKRAIW
     QGEREAIDIT IRIRGPKTET QEADRAAKKA RDRPQVDLET YCNKAEVRQK FREKELTKWQ
     SEWGKRNHRR EHIGFPAVTD EWPGLNERAV QLVTGHGYFK AYYRRFKLRE GSGLCECGEA
     EETADHVWWE CTVEERERAR REFTEAVGTR ADVRQKLSEV HRDRLISELN KLADAIVRDD
     SNLEQ