ID   PO12_NASVI              Reviewed;         410 AA.
AC   Q03270;
DT   01-JUN-1994, integrated into UniProtKB/Swiss-Prot.
DT   01-JUN-1994, sequence version 1.
DT   25-MAY-2022, entry version 67.
DE   RecName: Full=Retrovirus-related Pol polyprotein from type-1 retrotransposable element R1 2;
DE   AltName: Full=Retrovirus-related Pol polyprotein from type I retrotransposable element R1 2;
DE   Includes:
DE     RecName: Full=Reverse transcriptase;
DE              EC=2.7.7.49;
DE   Includes:
DE     RecName: Full=Endonuclease;
DE   Flags: Fragment;
OS   Nasonia vitripennis (Parasitic wasp).
OC   Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Hexapoda; Insecta; Pterygota;
OC   Neoptera; Endopterygota; Hymenoptera; Apocrita; Parasitoida; Chalcidoidea;
OC   Pteromalidae; Pteromalinae; Nasonia.
OX   NCBI_TaxID=7425;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [GENOMIC DNA].
RX   PubMed=8383793; DOI=10.1093/oxfordjournals.molbev.a039990;
RA   Burke W.D., Eickbush D.G., Xiong Y., Jakubczak J.L., Eickbush T.H.;
RT   "Sequence relationship of retrotransposable elements R1 and R2 within and
RT   between divergent insect species.";
RL   Mol. Biol. Evol. 10:163-185(1993).
CC   -!- CATALYTIC ACTIVITY:
CC       Reaction=a 2'-deoxyribonucleoside 5'-triphosphate + DNA(n) =
CC         diphosphate + DNA(n+1); Xref=Rhea:RHEA:22508, Rhea:RHEA-COMP:17339,
CC         Rhea:RHEA-COMP:17340, ChEBI:CHEBI:33019, ChEBI:CHEBI:61560,
CC         ChEBI:CHEBI:173112; EC=2.7.7.49; Evidence={ECO:0000255|PROSITE-
CC         ProRule:PRU00405};
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DR   EMBL; L00941; AAA30338.1; -; Genomic_DNA.
DR   PIR; C44490; C44490.
DR   AlphaFoldDB; Q03270; -.
DR   Proteomes; UP000002358; Unplaced.
DR   GO; GO:0004519; F:endonuclease activity; IEA:UniProtKB-KW.
DR   GO; GO:0003964; F:RNA-directed DNA polymerase activity; IEA:UniProtKB-KW.
DR   InterPro; IPR043502; DNA/RNA_pol_sf.
DR   InterPro; IPR000477; RT_dom.
DR   Pfam; PF00078; RVT_1; 1.
DR   SUPFAM; SSF56672; SSF56672; 1.
DR   PROSITE; PS50878; RT_POL; 1.
PE   4: Predicted;
KW   Endonuclease; Hydrolase; Nuclease; Nucleotidyltransferase;
KW   Reference proteome; RNA-directed DNA polymerase; Transferase;
KW   Transposable element.
FT   CHAIN           <1..410
FT                   /note="Retrovirus-related Pol polyprotein from type-1
FT                   retrotransposable element R1 2"
FT                   /id="PRO_0000058494"
FT   DOMAIN          <1..118
FT                   /note="Reverse transcriptase"
FT                   /evidence="ECO:0000255|PROSITE-ProRule:PRU00405"
FT   REGION          254..410
FT                   /note="Nucleic acid-binding endonuclease"
FT   NON_TER         1
SQ   SEQUENCE   410 AA;  46649 MW;  70E210F8B66A5845 CRC64;
     GCPQGSIGGP ILWNLSMNGM LIELAGSGVS VCAFADDVAI LAEGNTRKEV ERVINEKMEI
     VYKWGEKMGV SVSEEKTVCM LLKGKYVTSN RAVRVSKTIN VYKRIKYVSC FRYLGVNVTE
     GMGFGEHVRG MKVKVAKGVQ KLKRVLRRDW GLRRAASHLV LRGTFLPQVS YCASAWYEVL
     KYEYGRNALS AAVRYVMYAC LNVCRTVSTE AMQVLTGWLP WDLECLKRAN VYKVRKGLSM
     NEMDVVKNEE VESSSVIKLE RLVDERVYEI WQERWVVSMK GRVTARFIKD VKYAGRSRSF
     EPDRWVVNIL TGHGTLNAFL HKRGLSESAS CMCGDVSEDW EHVLCRCSMY ESFRNLDEMG
     VTVCVNGEYE FTGVLSSNVT YGKMCEFINR AYEMRESVRR RLNLELDVNG