ID   PO13_NASVI              Reviewed;         383 AA.
AC   Q03271;
DT   01-JUN-1994, integrated into UniProtKB/Swiss-Prot.
DT   01-JUN-1994, sequence version 1.
DT   25-MAY-2022, entry version 71.
DE   RecName: Full=Retrovirus-related Pol polyprotein from type-1 retrotransposable element R1 3;
DE   AltName: Full=Retrovirus-related Pol polyprotein from type I retrotransposable element R1 3;
DE   Includes:
DE     RecName: Full=Reverse transcriptase;
DE              EC=2.7.7.49;
DE   Includes:
DE     RecName: Full=Endonuclease;
DE   Flags: Fragment;
OS   Nasonia vitripennis (Parasitic wasp).
OC   Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Hexapoda; Insecta; Pterygota;
OC   Neoptera; Endopterygota; Hymenoptera; Apocrita; Parasitoida; Chalcidoidea;
OC   Pteromalidae; Pteromalinae; Nasonia.
OX   NCBI_TaxID=7425;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [GENOMIC DNA].
RX   PubMed=8383793; DOI=10.1093/oxfordjournals.molbev.a039990;
RA   Burke W.D., Eickbush D.G., Xiong Y., Jakubczak J.L., Eickbush T.H.;
RT   "Sequence relationship of retrotransposable elements R1 and R2 within and
RT   between divergent insect species.";
RL   Mol. Biol. Evol. 10:163-185(1993).
RN   [2]
RP   NUCLEOTIDE SEQUENCE [GENOMIC DNA] OF 307-323.
RX   PubMed=1849649; DOI=10.1073/pnas.88.8.3295;
RA   Jakubczak J.L., Burke W.D., Eickbush T.H.;
RT   "Retrotransposable elements R1 and R2 interrupt the rRNA genes of most
RT   insects.";
RL   Proc. Natl. Acad. Sci. U.S.A. 88:3295-3299(1991).
CC   -!- CATALYTIC ACTIVITY:
CC       Reaction=a 2'-deoxyribonucleoside 5'-triphosphate + DNA(n) =
CC         diphosphate + DNA(n+1); Xref=Rhea:RHEA:22508, Rhea:RHEA-COMP:17339,
CC         Rhea:RHEA-COMP:17340, ChEBI:CHEBI:33019, ChEBI:CHEBI:61560,
CC         ChEBI:CHEBI:173112; EC=2.7.7.49; Evidence={ECO:0000255|PROSITE-
CC         ProRule:PRU00405};
CC   ---------------------------------------------------------------------------
CC   Copyrighted by the UniProt Consortium, see https://www.uniprot.org/terms
CC   Distributed under the Creative Commons Attribution (CC BY 4.0) License
CC   ---------------------------------------------------------------------------
DR   EMBL; L00942; AAA30339.1; -; Genomic_DNA.
DR   PIR; D44490; D44490.
DR   AlphaFoldDB; Q03271; -.
DR   Proteomes; UP000002358; Unplaced.
DR   GO; GO:0004519; F:endonuclease activity; IEA:UniProtKB-KW.
DR   GO; GO:0003964; F:RNA-directed DNA polymerase activity; IEA:UniProtKB-KW.
DR   InterPro; IPR000477; RT_dom.
DR   PROSITE; PS50878; RT_POL; 1.
PE   4: Predicted;
KW   Endonuclease; Hydrolase; Nuclease; Nucleotidyltransferase;
KW   Reference proteome; RNA-directed DNA polymerase; Transferase;
KW   Transposable element.
FT   CHAIN           <1..383
FT                   /note="Retrovirus-related Pol polyprotein from type-1
FT                   retrotransposable element R1 3"
FT                   /id="PRO_0000058495"
FT   DOMAIN          <1..88
FT                   /note="Reverse transcriptase"
FT                   /evidence="ECO:0000255|PROSITE-ProRule:PRU00405"
FT   REGION          229..383
FT                   /note="Nucleic acid-binding endonuclease"
FT   NON_TER         1
SQ   SEQUENCE   383 AA;  43411 MW;  DE296B380925251B CRC64;
     VDAFADDLLL LVQGNRRNEL EQSASEALSV VYRYGTNIGV EVSDSKTVCM MLKGSLNMLN
     RVVHVSTNGM DDKRIRCVDR VRYLGVNVGI GMDFSVHIDG MKRRLTTAIM RLRGVLRKSW
     GLKRGVVSMV VKGLFLPAVM YGASVWYEQL HKRKLRGSRR LSEELVSCQR VVLYACTRVC
     RTVSTEAMQI LFGSLPWDIE CFRRANCTKS KGPAMNESDL VTDEDLYELS LHECRELVDQ
     RALAAWQDRW EATSNGRVTY EWIRDVGFSG RSMKYFGAEP EGLLRLTGHG SMNSFLFSRN
     LSNSPACACG TEREDWIHVL CECDMYAAFR DLDSIGVRRT EVGWDVSGVL LDRASMSVCV
     PLSSCAFRMR ELIVQRMREN EES