ID   PO14_NASVI              Reviewed;         392 AA.
AC   Q03272;
DT   01-JUN-1994, integrated into UniProtKB/Swiss-Prot.
DT   01-JUN-1994, sequence version 1.
DT   25-MAY-2022, entry version 67.
DE   RecName: Full=Retrovirus-related Pol polyprotein from type-1 retrotransposable element R1 4;
DE   AltName: Full=Retrovirus-related Pol polyprotein from type I retrotransposable element R1 4;
DE   Includes:
DE     RecName: Full=Reverse transcriptase;
DE              EC=2.7.7.49;
DE   Includes:
DE     RecName: Full=Endonuclease;
DE   Flags: Fragment;
OS   Nasonia vitripennis (Parasitic wasp).
OC   Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Hexapoda; Insecta; Pterygota;
OC   Neoptera; Endopterygota; Hymenoptera; Apocrita; Parasitoida; Chalcidoidea;
OC   Pteromalidae; Pteromalinae; Nasonia.
OX   NCBI_TaxID=7425;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [GENOMIC DNA].
RX   PubMed=8383793; DOI=10.1093/oxfordjournals.molbev.a039990;
RA   Burke W.D., Eickbush D.G., Xiong Y., Jakubczak J.L., Eickbush T.H.;
RT   "Sequence relationship of retrotransposable elements R1 and R2 within and
RT   between divergent insect species.";
RL   Mol. Biol. Evol. 10:163-185(1993).
CC   -!- CATALYTIC ACTIVITY:
CC       Reaction=a 2'-deoxyribonucleoside 5'-triphosphate + DNA(n) =
CC         diphosphate + DNA(n+1); Xref=Rhea:RHEA:22508, Rhea:RHEA-COMP:17339,
CC         Rhea:RHEA-COMP:17340, ChEBI:CHEBI:33019, ChEBI:CHEBI:61560,
CC         ChEBI:CHEBI:173112; EC=2.7.7.49;
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DR   EMBL; L00943; AAA30340.1; -; Genomic_DNA.
DR   PIR; E44490; E44490.
DR   AlphaFoldDB; Q03272; -.
DR   Proteomes; UP000002358; Unplaced.
DR   GO; GO:0004519; F:endonuclease activity; IEA:UniProtKB-KW.
DR   GO; GO:0003964; F:RNA-directed DNA polymerase activity; IEA:UniProtKB-KW.
PE   4: Predicted;
KW   Endonuclease; Hydrolase; Nuclease; Nucleotidyltransferase;
KW   Reference proteome; RNA-directed DNA polymerase; Transferase;
KW   Transposable element.
FT   CHAIN           <1..392
FT                   /note="Retrovirus-related Pol polyprotein from type-1
FT                   retrotransposable element R1 4"
FT                   /id="PRO_0000058496"
FT   DOMAIN          <1..230
FT                   /note="Reverse transcriptase"
FT   REGION          231..392
FT                   /note="Nucleic acid-binding endonuclease"
FT   NON_TER         1
SQ   SEQUENCE   392 AA;  43758 MW;  D644BD53EDAD77F6 CRC64;
     PFADDLAVLV EGDSRAEIEK VGKAVVKHIV ERCSAIKLEV SESKTVGIFV KKPKVVGSKA
     VKINRKDCRK GGARNLKIEL GGKSISFEQS VRYLGVHFDA NLGISAHCKY LREKLVPLFS
     DLRKLAQCQW GLGHKALETI YKGVFVPTVC YASARWYKEG AHTDRILEDL HRQILIAITR
     CYRSTSYEAA CVLAGTLPIC IQLRVSVAKY HLRKGEDAEI GGVVIRRRPE GLKENYNRVL
     EVANEMWQAR WEASEQGNAT RELFFPDVVA RVKSDWIRPD HFTSQVLTGH GYYNEKLHQL
     SLAKAAACIC CGEPDNNLHF LLECPAFAEF RDELITPVSG GLEAPEATLM LVSSPEGFAA
     LKEYSRVAFE CKRQLENALT ESDEGLSSES EE