ID   PO152_SCHPO             Reviewed;        1250 AA.
AC   O94385; Q9USB0;
DT   07-MAR-2006, integrated into UniProtKB/Swiss-Prot.
DT   07-MAR-2006, sequence version 3.
DT   03-AUG-2022, entry version 107.
DE   RecName: Full=Nucleoporin pom152;
GN   Name=pom152; ORFNames=SPBC29A10.07;
OS   Schizosaccharomyces pombe (strain 972 / ATCC 24843) (Fission yeast).
OC   Eukaryota; Fungi; Dikarya; Ascomycota; Taphrinomycotina;
OC   Schizosaccharomycetes; Schizosaccharomycetales; Schizosaccharomycetaceae;
OC   Schizosaccharomyces.
OX   NCBI_TaxID=284812;
RN   [1] {ECO:0000312|EMBL:CAA22435.1}
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=972 / ATCC 24843;
RX   PubMed=11859360; DOI=10.1038/nature724;
RA   Wood V., Gwilliam R., Rajandream M.A., Lyne M.H., Lyne R., Stewart A.,
RA   Sgouros J.G., Peat N., Hayles J., Baker S.G., Basham D., Bowman S.,
RA   Brooks K., Brown D., Brown S., Chillingworth T., Churcher C.M., Collins M.,
RA   Connor R., Cronin A., Davis P., Feltwell T., Fraser A., Gentles S.,
RA   Goble A., Hamlin N., Harris D.E., Hidalgo J., Hodgson G., Holroyd S.,
RA   Hornsby T., Howarth S., Huckle E.J., Hunt S., Jagels K., James K.D.,
RA   Jones L., Jones M., Leather S., McDonald S., McLean J., Mooney P.,
RA   Moule S., Mungall K.L., Murphy L.D., Niblett D., Odell C., Oliver K.,
RA   O'Neil S., Pearson D., Quail M.A., Rabbinowitsch E., Rutherford K.M.,
RA   Rutter S., Saunders D., Seeger K., Sharp S., Skelton J., Simmonds M.N.,
RA   Squares R., Squares S., Stevens K., Taylor K., Taylor R.G., Tivey A.,
RA   Walsh S.V., Warren T., Whitehead S., Woodward J.R., Volckaert G., Aert R.,
RA   Robben J., Grymonprez B., Weltjens I., Vanstreels E., Rieger M.,
RA   Schaefer M., Mueller-Auer S., Gabel C., Fuchs M., Duesterhoeft A.,
RA   Fritzc C., Holzer E., Moestl D., Hilbert H., Borzym K., Langer I., Beck A.,
RA   Lehrach H., Reinhardt R., Pohl T.M., Eger P., Zimmermann W., Wedler H.,
RA   Wambutt R., Purnelle B., Goffeau A., Cadieu E., Dreano S., Gloux S.,
RA   Lelaure V., Mottier S., Galibert F., Aves S.J., Xiang Z., Hunt C.,
RA   Moore K., Hurst S.M., Lucas M., Rochet M., Gaillardin C., Tallada V.A.,
RA   Garzon A., Thode G., Daga R.R., Cruzado L., Jimenez J., Sanchez M.,
RA   del Rey F., Benito J., Dominguez A., Revuelta J.L., Moreno S.,
RA   Armstrong J., Forsburg S.L., Cerutti L., Lowe T., McCombie W.R.,
RA   Paulsen I., Potashkin J., Shpakovski G.V., Ussery D., Barrell B.G.,
RA   Nurse P.;
RT   "The genome sequence of Schizosaccharomyces pombe.";
RL   Nature 415:871-880(2002).
RN   [2] {ECO:0000305, ECO:0000312|EMBL:BAA87205.1}
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA] OF 311-547, AND SUBCELLULAR
RP   LOCATION.
RC   STRAIN=ATCC 38364 / 968;
RX   PubMed=10759889; DOI=10.1046/j.1365-2443.2000.00317.x;
RA   Ding D.-Q., Tomita Y., Yamamoto A., Chikashige Y., Haraguchi T.,
RA   Hiraoka Y.;
RT   "Large-scale screening of intracellular protein localization in living
RT   fission yeast cells by the use of a GFP-fusion genomic DNA library.";
RL   Genes Cells 5:169-190(2000).
RN   [3]
RP   SUBCELLULAR LOCATION [LARGE SCALE ANALYSIS].
RX   PubMed=16823372; DOI=10.1038/nbt1222;
RA   Matsuyama A., Arai R., Yashiroda Y., Shirai A., Kamata A., Sekido S.,
RA   Kobayashi Y., Hashimoto A., Hamamoto M., Hiraoka Y., Horinouchi S.,
RA   Yoshida M.;
RT   "ORFeome cloning and global analysis of protein localization in the fission
RT   yeast Schizosaccharomyces pombe.";
RL   Nat. Biotechnol. 24:841-847(2006).
CC   -!- FUNCTION: Functions as a component of the nuclear pore complex (NPC).
CC       NPC components, collectively referred to as nucleoporins (NUPs), can
CC       play the role of both NPC structural components and of docking or
CC       interaction partners for transiently associated nuclear transport
CC       factors (By similarity). {ECO:0000250|UniProtKB:P39685}.
CC   -!- SUBUNIT: Component of the nuclear pore complex (NPC). NPC constitutes
CC       the exclusive means of nucleocytoplasmic transport. NPCs allow the
CC       passive diffusion of ions and small molecules and the active, nuclear
CC       transport receptor-mediated bidirectional transport of macromolecules
CC       such as proteins, RNAs, ribonucleoparticles (RNPs), and ribosomal
CC       subunits across the nuclear envelope (By similarity).
CC       {ECO:0000250|UniProtKB:P39685}.
CC   -!- SUBCELLULAR LOCATION: Nucleus, nuclear pore complex
CC       {ECO:0000269|PubMed:16823372}. Nucleus membrane
CC       {ECO:0000269|PubMed:10759889, ECO:0000269|PubMed:16823372}; Single-pass
CC       type II membrane protein. Note=Central core structure of the nuclear
CC       pore complex. {ECO:0000269|PubMed:16823372}.
CC   -!- SEQUENCE CAUTION:
CC       Sequence=BAA87205.1; Type=Frameshift; Evidence={ECO:0000305};
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DR   EMBL; CU329671; CAA22435.1; -; Genomic_DNA.
DR   EMBL; AB027901; BAA87205.1; ALT_FRAME; Genomic_DNA.
DR   PIR; T40062; T40062.
DR   RefSeq; NP_596052.1; NM_001021963.2.
DR   AlphaFoldDB; O94385; -.
DR   BioGRID; 276957; 20.
DR   IntAct; O94385; 1.
DR   MINT; O94385; -.
DR   STRING; 4896.SPBC29A10.07.1; -.
DR   MaxQB; O94385; -.
DR   PaxDb; O94385; -.
DR   PRIDE; O94385; -.
DR   EnsemblFungi; SPBC29A10.07.1; SPBC29A10.07.1:pep; SPBC29A10.07.
DR   GeneID; 2540429; -.
DR   KEGG; spo:SPBC29A10.07; -.
DR   PomBase; SPBC29A10.07; pom152.
DR   VEuPathDB; FungiDB:SPBC29A10.07; -.
DR   eggNOG; ENOG502QQ5B; Eukaryota.
DR   HOGENOM; CLU_002415_0_0_1; -.
DR   InParanoid; O94385; -.
DR   OMA; FDVFYTF; -.
DR   PhylomeDB; O94385; -.
DR   PRO; PR:O94385; -.
DR   Proteomes; UP000002485; Chromosome II.
DR   GO; GO:0016021; C:integral component of membrane; IEA:UniProtKB-KW.
DR   GO; GO:0005635; C:nuclear envelope; HDA:PomBase.
DR   GO; GO:0031965; C:nuclear membrane; IEA:UniProtKB-SubCell.
DR   GO; GO:0005643; C:nuclear pore; IDA:PomBase.
DR   GO; GO:0070762; C:nuclear pore transmembrane ring; IBA:GO_Central.
DR   GO; GO:0017056; F:structural constituent of nuclear pore; IEA:InterPro.
DR   GO; GO:0051028; P:mRNA transport; IEA:UniProtKB-KW.
DR   GO; GO:0006999; P:nuclear pore organization; IBA:GO_Central.
DR   GO; GO:0006913; P:nucleocytoplasmic transport; ISS:PomBase.
DR   GO; GO:0006606; P:protein import into nucleus; IBA:GO_Central.
DR   InterPro; IPR037701; Pom152.
DR   PANTHER; PTHR28206; PTHR28206; 1.
PE   3: Inferred from homology;
KW   Membrane; mRNA transport; Nuclear pore complex; Nucleus; Protein transport;
KW   Reference proteome; Translocation; Transmembrane; Transmembrane helix;
KW   Transport.
FT   CHAIN           1..1250
FT                   /note="Nucleoporin pom152"
FT                   /id="PRO_0000224645"
FT   TRANSMEM        80..100
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
FT   REGION          1..79
FT                   /note="Pore side"
FT                   /evidence="ECO:0000255"
FT   REGION          101..1250
FT                   /note="Cisternal side"
FT                   /evidence="ECO:0000255"
SQ   SEQUENCE   1250 AA;  139585 MW;  E409A1F2760D5D09 CRC64;
     MVTRVASSER PRPLVPESIV DAPTQRLYAI GVFVALQAYK IYDLLKLETS SISDVPKSGF
     LVKWIIIDAI YLRLLPKFRI PWLSFQPAAT LLQIAIFAAI NLLLSSLSSL KWISIGSILL
     PYFKKKELSI SEHKINPNNV IHNSSRILGQ YTLQVLPEGT AKINPLHENY CLNSLRKDQY
     VDLAIQFNST IPKYIQYSHV DLETKEETLV EVSGRSLRKL LSSSSKNPKE PRLQTIYLKT
     NKRGLYTLKH VVDKSKLDVR IFRSEAVVVS CPTATFASRQ SGGRLRERCV GDTDNAELKV
     TGVAPLQVTY RNWDGKHFNT HIIDSTIPDD FHPPAVVLSS NPKDIVFYKG IDIQWARSSE
     IFVPINTLLK APGQWIYAVT QVTDALGNSQ QFPSNDQFLL RFAHGYTEAD GESHSLPENV
     YSVFVHQRPD IQFRGCSIES PANLFPNKET SLSLYSSFSE YNSLEVGVDR YELGLDPQNI
     TVPPLSHKTY QISPRSSANI NVKKPGIYVL SSVSSQYCSG EVLEPNTCLV VTPPEAKVSV
     SFEEISDQCA GSIGARADLE LEGTPPFTIA YRMTKDNEAS RIQYVTTDRT RYQLNFTPKK
     AGKYRYIILG IQDANYGYRE LSGSSFYKDQ TVFPLADASF EERRNGDLST VVKTSCIGDT
     MSLPVLLTGS APWTLEYEIF RNNKREESHV VESKDPRYIL EVPMLVHGSQ YTITLVSVKD
     SNGCKRSLNT ADTVIKVRRQ RPTATFYSSD NTYTLKSVEG ALMKIPLRLA GEKPWYVEYS
     HTSGLNKVSH HKEVLNDPNS YLTVRKSGTY TLLSVSDSSC PGTIQNVEQK YQVEWLPRPF
     LSIPSLESSV KGKTRYYEQN AVCAGDSSAF EVQLSGSGPF LLKHDKILVD EKSKTYPKQK
     SELSTVQNTV LVKADTAVPG VYHYEFTKLS DSLYSDSDAV TIVNNQSYQA VVLQRVNSLP
     KASFMNVEKL YTFCINTDVT QSNAQLIAIQ LQGASPFSLV IGIKNELTGS VSKYTLNDIH
     ESVYKFAFPQ EQLTLGKHVV RLLQVRDANG CAASITKTQP AAKVSVVEMA SLAPLGSRQY
     YCVGDRLSFA LQGLPPFDVE YEFNGVTQHA TSDSHILTRL IELPGVVAMK SISDHGSHCK
     SYINPPIEQI VHDIPTVRIS NGKDVIENIH EGDQAEISFH FTGTPPFSFS YARRALGKKR
     PGKVLETHTV TGINEYEYKV LSSVEGVYTV LSVQDKYCRY PQDSTSSSNI