ID   PO21_NASVI              Reviewed;        1025 AA.
AC   Q03278;
DT   01-JUN-1994, integrated into UniProtKB/Swiss-Prot.
DT   15-JUL-1998, sequence version 2.
DT   03-AUG-2022, entry version 90.
DE   RecName: Full=Retrovirus-related Pol polyprotein from type-1 retrotransposable element R2;
DE   AltName: Full=Retrovirus-related Pol polyprotein from type I retrotransposable element R2;
DE   Includes:
DE     RecName: Full=Reverse transcriptase;
DE              EC=2.7.7.49;
DE   Includes:
DE     RecName: Full=Endonuclease;
DE   Flags: Fragment;
OS   Nasonia vitripennis (Parasitic wasp).
OC   Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Hexapoda; Insecta; Pterygota;
OC   Neoptera; Endopterygota; Hymenoptera; Apocrita; Parasitoida; Chalcidoidea;
OC   Pteromalidae; Pteromalinae; Nasonia.
OX   NCBI_TaxID=7425;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [GENOMIC DNA].
RX   PubMed=8383793; DOI=10.1093/oxfordjournals.molbev.a039990;
RA   Burke W.D., Eickbush D.G., Xiong Y., Jakubczak J.L., Eickbush T.H.;
RT   "Sequence relationship of retrotransposable elements R1 and R2 within and
RT   between divergent insect species.";
RL   Mol. Biol. Evol. 10:163-185(1993).
RN   [2]
RP   SEQUENCE REVISION.
RA   Burke W.D., Eickbush D.G., Xiong Y., Jakubczak J.L., Eickbush T.H.;
RL   Submitted (AUG-1997) to the EMBL/GenBank/DDBJ databases.
CC   -!- CATALYTIC ACTIVITY:
CC       Reaction=a 2'-deoxyribonucleoside 5'-triphosphate + DNA(n) =
CC         diphosphate + DNA(n+1); Xref=Rhea:RHEA:22508, Rhea:RHEA-COMP:17339,
CC         Rhea:RHEA-COMP:17340, ChEBI:CHEBI:33019, ChEBI:CHEBI:61560,
CC         ChEBI:CHEBI:173112; EC=2.7.7.49; Evidence={ECO:0000255|PROSITE-
CC         ProRule:PRU00405};
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DR   EMBL; L00950; AAC34927.1; -; Genomic_DNA.
DR   PIR; T10259; T10259.
DR   AlphaFoldDB; Q03278; -.
DR   PRIDE; Q03278; -.
DR   Proteomes; UP000002358; Unplaced.
DR   GO; GO:0004519; F:endonuclease activity; IEA:UniProtKB-KW.
DR   GO; GO:0046872; F:metal ion binding; IEA:UniProtKB-KW.
DR   GO; GO:0003964; F:RNA-directed DNA polymerase activity; IEA:UniProtKB-KW.
DR   Gene3D; 3.30.70.270; -; 1.
DR   InterPro; IPR043502; DNA/RNA_pol_sf.
DR   InterPro; IPR043128; Rev_trsase/Diguanyl_cyclase.
DR   InterPro; IPR000477; RT_dom.
DR   InterPro; IPR013087; Znf_C2H2_type.
DR   Pfam; PF00078; RVT_1; 1.
DR   SUPFAM; SSF56672; SSF56672; 1.
DR   PROSITE; PS50878; RT_POL; 1.
DR   PROSITE; PS00028; ZINC_FINGER_C2H2_1; 1.
DR   PROSITE; PS50157; ZINC_FINGER_C2H2_2; 1.
PE   4: Predicted;
KW   Endonuclease; Hydrolase; Metal-binding; Nuclease; Nucleotidyltransferase;
KW   Reference proteome; RNA-directed DNA polymerase; Transferase;
KW   Transposable element; Zinc; Zinc-finger.
FT   CHAIN           <1..1025
FT                   /note="Retrovirus-related Pol polyprotein from type-1
FT                   retrotransposable element R2"
FT                   /id="PRO_0000058497"
FT   DOMAIN          358..635
FT                   /note="Reverse transcriptase"
FT                   /evidence="ECO:0000255|PROSITE-ProRule:PRU00405"
FT   ZN_FING         46..69
FT                   /note="C2H2-type"
FT                   /evidence="ECO:0000255|PROSITE-ProRule:PRU00042"
FT   REGION          1..38
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   REGION          146..172
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   REGION          755..1025
FT                   /note="Nucleic acid-binding endonuclease"
FT   COMPBIAS        1..15
FT                   /note="Polar residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        146..162
FT                   /note="Basic and acidic residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   NON_TER         1
SQ   SEQUENCE   1025 AA;  115885 MW;  387BDE63BCF5C518 CRC64;
     NQIKKSNTST GARIPKAMTN PADNFAGGQW KPPGRRSART SATGMFVCEH CLRAFTTNTG
     RGLHIKRAHE EQANEAITTE RSRARWTNEE MEAVQAEIDC EGRTAINQEI LRIIPYQRTI
     DAIKCLRKQQ KYKTIRERVA NRRAENRARE TELTRLETAD EDPASQEQDN PNMSLKNWLK
     EVIESDDDRL CADLRTAIEM ALAGQSPLDV CTVGCYQYTM TNLPLVPVRL GGPIYWCNAQ
     SRSNPGETQR RQTIKESNNS WKKNMSKAAH IVLDGDTDAC PAGLEGTEAS GAIMRAGCPT
     TRHLRSRMQG EIKNLWRPIS NDEIKEVEAC KRTAAGPDGM TTTAWNSIDE CIKSLFNMIM
     YHGQCPRRYL DSRTVLIPKE PGTMDPACFR PLSIASVALR HFHRILANRI GEHGLLDTRQ
     RAFIVADGVA ENTSLLSAMI KEARMKIKGL YIAILDVKKA FDSVEHRSIL DALRRKKLPL
     EMRNYIMWVY RNSKTRLEVV KTKGRWIRPA RGVRQGDPLS PLLFNCVMDA VLRRLPENTG
     FLMGAEKIGA LVFADDLVLL AETREGLQAS LSRIEAGLQE QGLEMMPRKC HTLALVPSGK
     EKKIKVETHK PFTVGNQEIT QLGHADQWKY LGVVYNSYGP IQVKINIAGD LQRVTAAPLK
     PQQRMAILGM FLIPRFIHKL VLGRTSNADV RKGDKIIRKT VRGWLRLPHD TPIGYFHAPI
     KEGGLGIPAF ESRIPELLKS RIEALGASNM QTARSLLGGD WVAERKKWIN TQKIKNSEWA
     QKLHLTTDGK DLRDTRKAEA SYSWIRDIHV AIPASVWIKY HHTRINALPT LMRMSRGRRT
     NGNALCRAGC GLPETLYHVV QQCPRTHGGR VLRHDKIAEQ VAIFMQEKGW LVLREAHIRT
     SVGLRKPDII ARKGQDCKII DCQIVTTGND IRIQHERKIQ YYASNWELRR SAATMIGHQG
     QVSVEAITIS WKGVWEPRSY CLLRDCGIPK VKIKGLTTRV LLGAYLNFNT FSKATYRTER
     RRTAN