ID   PO21_POPJA              Reviewed;         445 AA.
AC   Q03273;
DT   01-JUN-1994, integrated into UniProtKB/Swiss-Prot.
DT   01-JUN-1994, sequence version 1.
DT   25-MAY-2022, entry version 59.
DE   RecName: Full=Retrovirus-related Pol polyprotein from type-1 retrotransposable element R2;
DE   AltName: Full=Retrovirus-related Pol polyprotein from type I retrotransposable element R2;
DE   Includes:
DE     RecName: Full=Reverse transcriptase;
DE              EC=2.7.7.49;
DE   Includes:
DE     RecName: Full=Endonuclease;
DE   Flags: Fragment;
OS   Popillia japonica (Japanese beetle).
OC   Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Hexapoda; Insecta; Pterygota;
OC   Neoptera; Endopterygota; Coleoptera; Polyphaga; Scarabaeiformia;
OC   Scarabaeidae; Rutelinae; Popillia.
OX   NCBI_TaxID=7064;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [GENOMIC DNA].
RX   PubMed=8383793; DOI=10.1093/oxfordjournals.molbev.a039990;
RA   Burke W.D., Eickbush D.G., Xiong Y., Jakubczak J.L., Eickbush T.H.;
RT   "Sequence relationship of retrotransposable elements R1 and R2 within and
RT   between divergent insect species.";
RL   Mol. Biol. Evol. 10:163-185(1993).
RN   [2]
RP   NUCLEOTIDE SEQUENCE [GENOMIC DNA] OF 206-223.
RX   PubMed=1849649; DOI=10.1073/pnas.88.8.3295;
RA   Jakubczak J.L., Burke W.D., Eickbush T.H.;
RT   "Retrotransposable elements R1 and R2 interrupt the rRNA genes of most
RT   insects.";
RL   Proc. Natl. Acad. Sci. U.S.A. 88:3295-3299(1991).
CC   -!- CATALYTIC ACTIVITY:
CC       Reaction=a 2'-deoxyribonucleoside 5'-triphosphate + DNA(n) =
CC         diphosphate + DNA(n+1); Xref=Rhea:RHEA:22508, Rhea:RHEA-COMP:17339,
CC         Rhea:RHEA-COMP:17340, ChEBI:CHEBI:33019, ChEBI:CHEBI:61560,
CC         ChEBI:CHEBI:173112; EC=2.7.7.49;
CC   ---------------------------------------------------------------------------
CC   Copyrighted by the UniProt Consortium, see https://www.uniprot.org/terms
CC   Distributed under the Creative Commons Attribution (CC BY 4.0) License
CC   ---------------------------------------------------------------------------
DR   EMBL; L00946; AAA29784.1; -; Genomic_DNA.
DR   PIR; C47757; C47757.
DR   AlphaFoldDB; Q03273; -.
DR   GO; GO:0004519; F:endonuclease activity; IEA:UniProtKB-KW.
DR   GO; GO:0003964; F:RNA-directed DNA polymerase activity; IEA:UniProtKB-KW.
PE   4: Predicted;
KW   Endonuclease; Hydrolase; Nuclease; Nucleotidyltransferase;
KW   RNA-directed DNA polymerase; Transferase; Transposable element.
FT   CHAIN           <1..445
FT                   /note="Retrovirus-related Pol polyprotein from type-1
FT                   retrotransposable element R2"
FT                   /id="PRO_0000058498"
FT   DOMAIN          <1..114
FT                   /note="Reverse transcriptase"
FT   REGION          115..445
FT                   /note="Nucleic acid-binding endonuclease"
FT   REGION          380..445
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        393..409
FT                   /note="Polar residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   NON_TER         1
SQ   SEQUENCE   445 AA;  50127 MW;  2FD15CB26E82A17D CRC64;
     QPSVFNLVKW LANLHKAPLK PDQKLAMLKR HIIPKLHYGL QTPNITGQIL SEADRLIRKA
     VRRVLHLSVH TGSQFLYAAI RDGGLGIPQL RYHIPDVLRR RLENLSRDDS LAKAMLASAG
     PAAEFRQRVS VLAARGPPQA YWREQVATRP FSRGLEDCAH DAASREWLLR TPAGWTGRDF
     VRAAQLRTGN LPTMGLPYIP RERRRCRAGC ERVESVSHIL QACPVTHFER IKRHDEIVRK
     IAAHCRKRGW TTEVEPRIYH QDGQLFIPDL AVHLAAESIL VCDVQVCWEG HRTLAKSWQN
     KKLVYDHPRF RKAAARRWAG SRIAISPLVL GPVGVWPRSN AETAALLQLP KTIKGSCIQS
     CLKWGSSIHK IFMASVWKHG PRPAHHHQPR PPEGQATANT GTLQSGRPAL SHSRKKRKRQ
     LTPTQRAPSL ASPPAGATPR QLIEY