ID   PO22_POPJA              Reviewed;         711 AA.
AC   Q03274;
DT   01-JUN-1994, integrated into UniProtKB/Swiss-Prot.
DT   01-JUN-1994, sequence version 1.
DT   25-MAY-2022, entry version 67.
DE   RecName: Full=Retrovirus-related Pol polyprotein from type-1 retrotransposable element R2;
DE   AltName: Full=Retrovirus-related Pol polyprotein from type I retrotransposable element R2;
DE   Includes:
DE     RecName: Full=Reverse transcriptase;
DE              EC=2.7.7.49;
DE   Includes:
DE     RecName: Full=Endonuclease;
DE   Flags: Fragment;
OS   Popillia japonica (Japanese beetle).
OC   Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Hexapoda; Insecta; Pterygota;
OC   Neoptera; Endopterygota; Coleoptera; Polyphaga; Scarabaeiformia;
OC   Scarabaeidae; Rutelinae; Popillia.
OX   NCBI_TaxID=7064;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [GENOMIC DNA].
RX   PubMed=8383793; DOI=10.1093/oxfordjournals.molbev.a039990;
RA   Burke W.D., Eickbush D.G., Xiong Y., Jakubczak J.L., Eickbush T.H.;
RT   "Sequence relationship of retrotransposable elements R1 and R2 within and
RT   between divergent insect species.";
RL   Mol. Biol. Evol. 10:163-185(1993).
RN   [2]
RP   NUCLEOTIDE SEQUENCE [GENOMIC DNA] OF 534-551.
RX   PubMed=1849649; DOI=10.1073/pnas.88.8.3295;
RA   Jakubczak J.L., Burke W.D., Eickbush T.H.;
RT   "Retrotransposable elements R1 and R2 interrupt the rRNA genes of most
RT   insects.";
RL   Proc. Natl. Acad. Sci. U.S.A. 88:3295-3299(1991).
CC   -!- CATALYTIC ACTIVITY:
CC       Reaction=a 2'-deoxyribonucleoside 5'-triphosphate + DNA(n) =
CC         diphosphate + DNA(n+1); Xref=Rhea:RHEA:22508, Rhea:RHEA-COMP:17339,
CC         Rhea:RHEA-COMP:17340, ChEBI:CHEBI:33019, ChEBI:CHEBI:61560,
CC         ChEBI:CHEBI:173112; EC=2.7.7.49; Evidence={ECO:0000255|PROSITE-
CC         ProRule:PRU00405};
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DR   EMBL; L00947; AAA29785.1; -; Genomic_DNA.
DR   PIR; H44490; H44490.
DR   AlphaFoldDB; Q03274; -.
DR   PRIDE; Q03274; -.
DR   GO; GO:0004519; F:endonuclease activity; IEA:UniProtKB-KW.
DR   GO; GO:0003964; F:RNA-directed DNA polymerase activity; IEA:UniProtKB-KW.
DR   InterPro; IPR043502; DNA/RNA_pol_sf.
DR   InterPro; IPR000477; RT_dom.
DR   Pfam; PF00078; RVT_1; 1.
DR   SUPFAM; SSF56672; SSF56672; 1.
DR   PROSITE; PS50878; RT_POL; 1.
PE   4: Predicted;
KW   Endonuclease; Hydrolase; Nuclease; Nucleotidyltransferase;
KW   RNA-directed DNA polymerase; Transferase; Transposable element.
FT   CHAIN           <1..711
FT                   /note="Retrovirus-related Pol polyprotein from type-1
FT                   retrotransposable element R2"
FT                   /id="PRO_0000058500"
FT   DOMAIN          45..323
FT                   /note="Reverse transcriptase"
FT                   /evidence="ECO:0000255|PROSITE-ProRule:PRU00405"
FT   REGION          444..711
FT                   /note="Nucleic acid-binding endonuclease"
FT   NON_TER         1
SQ   SEQUENCE   711 AA;  79459 MW;  EAA25C9085F12D04 CRC64;
     HTYRPIAREE IQCAIKGWKP SAPGSDGLTV QAITRTRLPR NFVQLHLLRG HVPTPWTAMR
     TTLIPKDGDL ENPSNWRPIT IASALQRLLH RILAKRLEAA VELHPAQKGY ARIDGTLVNS
     LLLDTYISSR REQRKTYNVV SLDVRKAFDT VSHSSICRAL QRLGIDEGTS NYITGSLSDS
     TTTIRVGPGS QTRKICIRRG VKQGDPLSPF LFNAVLDELL CSLQSTPGIG GTIGEEKIPV
     LAFADDLLLL EDNDVLLPTT LATVANFFRL RGMSLNAKKS VSISVAASGG VCIPRTKPFL
     RVDNVLLPVT DRMQTFRYLG HFFGLSGAAK PTVYNLSRWL KCVEAAPLKP EQKLSLIREH
     VVPKLLYGLQ NPSVTARTLR DADKLIRTTV KRCLHLHLHT PNQCFYARVR DGGLGLTDLR
     RSIPRIMLDR INARRSSDPM AVALFSCPSF DHLRGRLVAL AGDVPPSHFW REAIANHTTT
     KGLEAASDDP ASRSWIFRKP YGWSGKDFVR AIHLRTGNLP TKAIPSNPAG ERLCRGGCGK
     QATISHVLQR CPVVQPERIR RHNEIARKIA AHCRSKGWTV EEEPHIRHPL GHLYKPDIVI
     HREGLPSVVC DVQVSWDGYE PLDEAWRNKQ RTYDHDLFRT AAGRRWPGKT FLHLPAILGA
     RGIWPRCNSE TASALAFTNQ LKASWLHSCL KWDSTLHTSF MRAVWSRQAG A