ID   PO24_POPJA              Reviewed;         482 AA.
AC   Q03275;
DT   01-JUN-1994, integrated into UniProtKB/Swiss-Prot.
DT   15-JUL-1998, sequence version 2.
DT   25-MAY-2022, entry version 66.
DE   RecName: Full=Retrovirus-related Pol polyprotein from type-1 retrotransposable element R2;
DE   AltName: Full=Retrovirus-related Pol polyprotein from type I retrotransposable element R2;
DE   Includes:
DE     RecName: Full=Reverse transcriptase;
DE              EC=2.7.7.49;
DE   Includes:
DE     RecName: Full=Endonuclease;
DE   Flags: Fragment;
OS   Popillia japonica (Japanese beetle).
OC   Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Hexapoda; Insecta; Pterygota;
OC   Neoptera; Endopterygota; Coleoptera; Polyphaga; Scarabaeiformia;
OC   Scarabaeidae; Rutelinae; Popillia.
OX   NCBI_TaxID=7064;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [GENOMIC DNA].
RX   PubMed=8383793; DOI=10.1093/oxfordjournals.molbev.a039990;
RA   Burke W.D., Eickbush D.G., Xiong Y., Jakubczak J.L., Eickbush T.H.;
RT   "Sequence relationship of retrotransposable elements R1 and R2 within and
RT   between divergent insect species.";
RL   Mol. Biol. Evol. 10:163-185(1993).
RN   [2]
RP   SEQUENCE REVISION.
RA   Burke W.D., Eickbush D.G., Xiong Y., Jakubczak J.L., Eickbush T.H.;
RL   Submitted (AUG-1997) to the EMBL/GenBank/DDBJ databases.
CC   -!- CATALYTIC ACTIVITY:
CC       Reaction=a 2'-deoxyribonucleoside 5'-triphosphate + DNA(n) =
CC         diphosphate + DNA(n+1); Xref=Rhea:RHEA:22508, Rhea:RHEA-COMP:17339,
CC         Rhea:RHEA-COMP:17340, ChEBI:CHEBI:33019, ChEBI:CHEBI:61560,
CC         ChEBI:CHEBI:173112; EC=2.7.7.49; Evidence={ECO:0000255|PROSITE-
CC         ProRule:PRU00405};
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DR   EMBL; L00949; AAB66358.1; -; Genomic_DNA.
DR   PIR; B47757; B47757.
DR   AlphaFoldDB; Q03275; -.
DR   GO; GO:0004519; F:endonuclease activity; IEA:UniProtKB-KW.
DR   GO; GO:0003964; F:RNA-directed DNA polymerase activity; IEA:UniProtKB-KW.
DR   InterPro; IPR000477; RT_dom.
DR   PROSITE; PS50878; RT_POL; 1.
PE   4: Predicted;
KW   Endonuclease; Hydrolase; Nuclease; Nucleotidyltransferase;
KW   RNA-directed DNA polymerase; Transferase; Transposable element.
FT   CHAIN           <1..482
FT                   /note="Retrovirus-related Pol polyprotein from type-1
FT                   retrotransposable element R2"
FT                   /id="PRO_0000058502"
FT   DOMAIN          <1..84
FT                   /note="Reverse transcriptase"
FT                   /evidence="ECO:0000255|PROSITE-ProRule:PRU00405"
FT   REGION          208..482
FT                   /note="Nucleic acid-binding endonuclease"
FT   NON_TER         1
SQ   SEQUENCE   482 AA;  53735 MW;  8631D8F114054C94 CRC64;
     AYADDLILFA NDHRAANRLL KVATEFFRER GLALNATKSA ALSVGVVPGK KQLYTHTKNL
     FYVGGKAIPQ LTPDDYFKYL GSRYNFSGQV RPSVELLKTQ LARVQSAPLK PAQKLTMIRD
     HVVARFLSCL QSVRVTLKAL KDADRLVRLS VRKVLHLNKS SPDAYIHAPI REGGLGIISL
     RAHIPAIMRS RLFKIATTAD PLTATVLQIP AVEKFYQTLL RWTEGNGGST TNIRKEWGRK
     LQESYSGNGL RQGNTSGVSG DWLRNPPNFW SGADYIDAVR LRGNLLPTRG IPSNPPHERK
     CRAGCNKTES LSHVLQGCPL THWHPIRRHD RVAGRLRQIA EKKGWMVEEE MRLRLADGSL
     RKPDLVMAQG DTIVVCDVTI VWEGPNPLTM AYHQKVAYYS QQPVLDAIHD RFPGRSVVVL
     ALVLGARGTW CDQNNAITDT LSLSRAQNSL INNCINGSII VHREFMRTSF TRATGGRGRG
     DI