PO2F1_CHICK
ID PO2F1_CHICK Reviewed; 739 AA.
AC P15143;
DT 01-APR-1990, integrated into UniProtKB/Swiss-Prot.
DT 01-APR-1990, sequence version 1.
DT 03-AUG-2022, entry version 140.
DE RecName: Full=POU domain, class 2, transcription factor 1;
DE AltName: Full=NF-A1;
DE AltName: Full=Octamer-binding protein 1;
DE Short=Oct-1;
DE AltName: Full=Octamer-binding transcription factor 1;
DE Short=OTF-1;
GN Name=POU2F1; Synonyms=OCT1, OTF1;
OS Gallus gallus (Chicken).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC Archelosauria; Archosauria; Dinosauria; Saurischia; Theropoda;
OC Coelurosauria; Aves; Neognathae; Galloanserae; Galliformes; Phasianidae;
OC Phasianinae; Gallus.
OX NCBI_TaxID=9031;
RN [1]
RP NUCLEOTIDE SEQUENCE [MRNA].
RX PubMed=1967834; DOI=10.1073/pnas.87.3.1099;
RA Petryniak B., Staudt L.M., Postema C.E., McCormack W.T., Thompson C.B.;
RT "Characterization of chicken octamer-binding proteins demonstrates that POU
RT domain-containing homeobox transcription factors have been highly conserved
RT during vertebrate evolution.";
RL Proc. Natl. Acad. Sci. U.S.A. 87:1099-1103(1990).
CC -!- FUNCTION: Transcription factor that binds to the octamer motif (5'-
CC ATTTGCAT-3') and activates the promoters of the genes for some small
CC nuclear RNAs (snRNA) and of genes such as those for histone H2B and
CC immunoglobulins. Modulates transcription transactivation by NR3C1, AR
CC and PGR (By similarity). {ECO:0000250}.
CC -!- SUBUNIT: Interacts with NR3C1, AR and PGR. {ECO:0000250}.
CC -!- SUBCELLULAR LOCATION: Nucleus.
CC -!- SIMILARITY: Belongs to the POU transcription factor family. Class-2
CC subfamily. {ECO:0000305}.
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DR EMBL; M29972; AAA48993.1; -; mRNA.
DR PIR; A34873; A34873.
DR RefSeq; NP_990803.1; NM_205472.1.
DR AlphaFoldDB; P15143; -.
DR SMR; P15143; -.
DR STRING; 9031.ENSGALP00000029768; -.
DR PaxDb; P15143; -.
DR GeneID; 396463; -.
DR KEGG; gga:396463; -.
DR CTD; 5451; -.
DR VEuPathDB; HostDB:geneid_396463; -.
DR eggNOG; KOG3802; Eukaryota.
DR InParanoid; P15143; -.
DR OrthoDB; 873012at2759; -.
DR PhylomeDB; P15143; -.
DR PRO; PR:P15143; -.
DR Proteomes; UP000000539; Unplaced.
DR GO; GO:0005634; C:nucleus; IEA:UniProtKB-SubCell.
DR GO; GO:0000981; F:DNA-binding transcription factor activity, RNA polymerase II-specific; IBA:GO_Central.
DR GO; GO:0000978; F:RNA polymerase II cis-regulatory region sequence-specific DNA binding; IBA:GO_Central.
DR GO; GO:0001223; F:transcription coactivator binding; IPI:AgBase.
DR GO; GO:0006357; P:regulation of transcription by RNA polymerase II; IBA:GO_Central.
DR CDD; cd00086; homeodomain; 1.
DR Gene3D; 1.10.260.40; -; 1.
DR InterPro; IPR009057; Homeobox-like_sf.
DR InterPro; IPR017970; Homeobox_CS.
DR InterPro; IPR001356; Homeobox_dom.
DR InterPro; IPR010982; Lambda_DNA-bd_dom_sf.
DR InterPro; IPR013847; POU.
DR InterPro; IPR045703; POU2F1_C.
DR InterPro; IPR000327; POU_dom.
DR InterPro; IPR000972; TF_octamer.
DR Pfam; PF00046; Homeodomain; 1.
DR Pfam; PF00157; Pou; 1.
DR Pfam; PF19536; POU2F1_C; 1.
DR PRINTS; PR00029; OCTAMER.
DR PRINTS; PR00028; POUDOMAIN.
DR SMART; SM00389; HOX; 1.
DR SMART; SM00352; POU; 1.
DR SUPFAM; SSF46689; SSF46689; 1.
DR SUPFAM; SSF47413; SSF47413; 1.
DR PROSITE; PS00027; HOMEOBOX_1; 1.
DR PROSITE; PS50071; HOMEOBOX_2; 1.
DR PROSITE; PS00035; POU_1; 1.
DR PROSITE; PS00465; POU_2; 1.
DR PROSITE; PS51179; POU_3; 1.
PE 2: Evidence at transcript level;
KW Activator; DNA-binding; Homeobox; Nucleus; Reference proteome;
KW Transcription; Transcription regulation.
FT CHAIN 1..739
FT /note="POU domain, class 2, transcription factor 1"
FT /id="PRO_0000100712"
FT DOMAIN 274..348
FT /note="POU-specific"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00530"
FT DNA_BIND 375..434
FT /note="Homeobox"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00108"
FT REGION 1..39
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 67..95
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 253..277
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 353..378
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 489..553
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 1..29
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 253..270
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 353..367
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 739 AA; 75982 MW; 815A2AD8F55D6FE2 CRC64;
MNNPSETSKP SMESGDGNTG TQTNGLDFQK QPVPVGGPIS TAQAQAFLGH LHQVQLAGTS
LQAAAQSLNV QSKSNEESGD SQQPSQPSQQ PSVQAAIPQT QLMLAGGQIT GLTLTPAQQQ
LLLQQAQAQL LAAAVQHSAS QQHSAAGATI SASAATPMTQ IPLSQPIQIA QHLQQLQQQN
LNLQQFVLVH PTTNLQPAQF IISQTPQGQQ GLLQAQNLLT QLPQQSQANL LQSQPSITLA
SQPATPTRTI AATPIQPLPQ SQSTPKRIDT PSLEEPSDLE ELEQFAKTFK QRRIKLGFTQ
GDVGLAMGKL YGNDFSQTTI SRFEALNLSF KNMCKLKPLL EKWLNDAENL SSDSTLSSPS
ALNSPGQGIE GVNRRRKKRT SIETNIRVAL EKSFLENQKP TSEEITMIAD QLNMEKEVIR
VWFCNRRQKE KRINPPSSGG TSSSPIKAIF PSPTSLVATT PSLVTSSAAT TLTVNPVLPL
TSPAVTSLSV TGTTETTSNN TATVISTAPP ASSAVTSPSL SPSPSASASI SEASSASETS
TTQTTSTPLS SPLGTSQVMV TASGLQTAAA AALQGAAQLP ANASLAAMAA AAGLNPGLMA
SSQFAAGGAL LSLNPGTLGG ALSPALMSNS TLATIQALAS SGSLPITSLD ASGNLVFANA
GGTPNIVTAP LFLNPQNLSL LTSNPVSLVS AAAASAGASG PVASLHATST SAESIQNSLL
TVASASGATS TTTTASKAQ
