ID   PO2F1_NOTEU             Reviewed;          75 AA.
AC   Q28466;
DT   15-JUL-1998, integrated into UniProtKB/Swiss-Prot.
DT   01-NOV-1996, sequence version 1.
DT   25-MAY-2022, entry version 65.
DE   RecName: Full=POU domain, class 2, transcription factor 1;
DE   AltName: Full=NF-A1;
DE   AltName: Full=Octamer-binding protein 1;
DE            Short=Oct-1;
DE   AltName: Full=Octamer-binding transcription factor 1;
DE            Short=OTF-1;
DE   Flags: Fragment;
GN   Name=POU2F1; Synonyms=OCT-1, OCT1, OTF1;
OS   Notamacropus eugenii (Tammar wallaby) (Macropus eugenii).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC   Metatheria; Diprotodontia; Macropodidae; Notamacropus.
OX   NCBI_TaxID=9315;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [GENOMIC DNA].
RX   PubMed=8258303; DOI=10.1159/000133646;
RA   Sturm R.A., Francis D.I., Cassady J.L., Graves J.A.;
RT   "Identification of a marsupial OTF1 gene: cross-species STS analysis and in
RT   situ cross-hybridization to Macropus eugenii chromosomes 3/4 and 5.";
RL   Cytogenet. Cell Genet. 65:272-275(1994).
CC   -!- FUNCTION: Transcription factor that binds to the octamer motif (5'-
CC       ATTTGCAT-3') and activates the promoters of the genes for some small
CC       nuclear RNAs (snRNA) and of genes such as those for histone H2B and
CC       immunoglobulins. Modulates transcription transactivation by NR3C1, AR
CC       and PGR. {ECO:0000250|UniProtKB:P14859}.
CC   -!- SUBUNIT: Interacts with POU2AF1; the interaction increases POU2F1
CC       transactivation activity. Interacts with NR3C1, AR, PGR and HCFC1.
CC       {ECO:0000250|UniProtKB:P14859}.
CC   -!- SUBCELLULAR LOCATION: Nucleus.
CC   -!- PTM: Phosphorylated by PRKDC. {ECO:0000250}.
CC   -!- SIMILARITY: Belongs to the POU transcription factor family. Class-2
CC       subfamily. {ECO:0000305}.
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DR   EMBL; M97955; AAA31607.1; -; Genomic_DNA.
DR   AlphaFoldDB; Q28466; -.
DR   GO; GO:0005634; C:nucleus; IEA:UniProtKB-SubCell.
DR   GO; GO:0003677; F:DNA binding; IEA:UniProtKB-KW.
DR   InterPro; IPR045703; POU2F1_C.
DR   Pfam; PF19536; POU2F1_C; 1.
PE   3: Inferred from homology;
KW   Activator; DNA-binding; Homeobox; Nucleus; Transcription;
KW   Transcription regulation.
FT   CHAIN           <1..>75
FT                   /note="POU domain, class 2, transcription factor 1"
FT                   /id="PRO_0000100709"
FT   REGION          1..56
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   NON_TER         1
FT   NON_TER         75
SQ   SEQUENCE   75 AA;  7023 MW;  C0D3735CE091B654 CRC64;
     NNTATVISAA PPASSAVTLP SMSPSPSASA SEASSASETS TTQTTSTPLS SPLGTGQVMV
     TASGLQTAAA ALQGA