PO2F3_HUMAN
ID PO2F3_HUMAN Reviewed; 436 AA.
AC Q9UKI9; A8K7H8; B4DY07; F5GWW6; Q3MIY3; Q9UKR7; Q9Y504;
DT 01-FEB-2003, integrated into UniProtKB/Swiss-Prot.
DT 02-NOV-2010, sequence version 3.
DT 03-AUG-2022, entry version 180.
DE RecName: Full=POU domain, class 2, transcription factor 3;
DE AltName: Full=Octamer-binding protein 11;
DE Short=Oct-11;
DE AltName: Full=Octamer-binding transcription factor 11;
DE Short=OTF-11;
DE AltName: Full=Transcription factor PLA-1;
DE AltName: Full=Transcription factor Skn-1;
GN Name=POU2F3; Synonyms=OTF11, PLA1;
OS Homo sapiens (Human).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae;
OC Homo.
OX NCBI_TaxID=9606;
RN [1]
RP NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM 1), AND VARIANT ARG-152.
RX PubMed=10473598; DOI=10.1074/jbc.274.37.26399;
RA Hildesheim J., Foster R.A., Chamberlin M.E., Vogel J.C.;
RT "Characterization of the regulatory domains of the human skn-1a/Epoc-1/Oct-
RT 11 POU transcription factor.";
RL J. Biol. Chem. 274:26399-26406(1999).
RN [2]
RP NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM 1), AND VARIANT ARG-152.
RA Fischer D.F., Hemelaar J., Backendorf C.;
RT "Characterisation of the human transcription factor Oct-11: involvement in
RT the regulation of the SPRR2A gene.";
RL Submitted (MAR-1999) to the EMBL/GenBank/DDBJ databases.
RN [3]
RP NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM 1).
RC TISSUE=Placenta;
RA Jimenez-Mateo O., Castrillo J.-L.;
RT "PLA-1, a novel human POU transcription factor, regulates the placental
RT lactogen-3 gene expression.";
RL Submitted (OCT-1998) to the EMBL/GenBank/DDBJ databases.
RN [4]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORMS 1 AND 2), AND VARIANTS
RP ARG-152 AND LYS-390.
RC TISSUE=Small intestine, and Testis;
RX PubMed=14702039; DOI=10.1038/ng1285;
RA Ota T., Suzuki Y., Nishikawa T., Otsuki T., Sugiyama T., Irie R.,
RA Wakamatsu A., Hayashi K., Sato H., Nagai K., Kimura K., Makita H.,
RA Sekine M., Obayashi M., Nishi T., Shibahara T., Tanaka T., Ishii S.,
RA Yamamoto J., Saito K., Kawai Y., Isono Y., Nakamura Y., Nagahari K.,
RA Murakami K., Yasuda T., Iwayanagi T., Wagatsuma M., Shiratori A., Sudo H.,
RA Hosoiri T., Kaku Y., Kodaira H., Kondo H., Sugawara M., Takahashi M.,
RA Kanda K., Yokoi T., Furuya T., Kikkawa E., Omura Y., Abe K., Kamihara K.,
RA Katsuta N., Sato K., Tanikawa M., Yamazaki M., Ninomiya K., Ishibashi T.,
RA Yamashita H., Murakawa K., Fujimori K., Tanai H., Kimata M., Watanabe M.,
RA Hiraoka S., Chiba Y., Ishida S., Ono Y., Takiguchi S., Watanabe S.,
RA Yosida M., Hotuta T., Kusano J., Kanehori K., Takahashi-Fujii A., Hara H.,
RA Tanase T.-O., Nomura Y., Togiya S., Komai F., Hara R., Takeuchi K.,
RA Arita M., Imose N., Musashino K., Yuuki H., Oshima A., Sasaki N.,
RA Aotsuka S., Yoshikawa Y., Matsunawa H., Ichihara T., Shiohata N., Sano S.,
RA Moriya S., Momiyama H., Satoh N., Takami S., Terashima Y., Suzuki O.,
RA Nakagawa S., Senoh A., Mizoguchi H., Goto Y., Shimizu F., Wakebe H.,
RA Hishigaki H., Watanabe T., Sugiyama A., Takemoto M., Kawakami B.,
RA Yamazaki M., Watanabe K., Kumagai A., Itakura S., Fukuzumi Y., Fujimori Y.,
RA Komiyama M., Tashiro H., Tanigami A., Fujiwara T., Ono T., Yamada K.,
RA Fujii Y., Ozaki K., Hirao M., Ohmori Y., Kawabata A., Hikiji T.,
RA Kobatake N., Inagaki H., Ikema Y., Okamoto S., Okitani R., Kawakami T.,
RA Noguchi S., Itoh T., Shigeta K., Senba T., Matsumura K., Nakajima Y.,
RA Mizuno T., Morinaga M., Sasaki M., Togashi T., Oyama M., Hata H.,
RA Watanabe M., Komatsu T., Mizushima-Sugano J., Satoh T., Shirai Y.,
RA Takahashi Y., Nakagawa K., Okumura K., Nagase T., Nomura N., Kikuchi H.,
RA Masuho Y., Yamashita R., Nakai K., Yada T., Nakamura Y., Ohara O.,
RA Isogai T., Sugano S.;
RT "Complete sequencing and characterization of 21,243 full-length human
RT cDNAs.";
RL Nat. Genet. 36:40-45(2004).
RN [5]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RX PubMed=16554811; DOI=10.1038/nature04632;
RA Taylor T.D., Noguchi H., Totoki Y., Toyoda A., Kuroki Y., Dewar K.,
RA Lloyd C., Itoh T., Takeda T., Kim D.-W., She X., Barlow K.F., Bloom T.,
RA Bruford E., Chang J.L., Cuomo C.A., Eichler E., FitzGerald M.G.,
RA Jaffe D.B., LaButti K., Nicol R., Park H.-S., Seaman C., Sougnez C.,
RA Yang X., Zimmer A.R., Zody M.C., Birren B.W., Nusbaum C., Fujiyama A.,
RA Hattori M., Rogers J., Lander E.S., Sakaki Y.;
RT "Human chromosome 11 DNA sequence and analysis including novel gene
RT identification.";
RL Nature 440:497-500(2006).
RN [6]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 1).
RC TISSUE=Brain;
RX PubMed=15489334; DOI=10.1101/gr.2596504;
RG The MGC Project Team;
RT "The status, quality, and expansion of the NIH full-length cDNA project:
RT the Mammalian Gene Collection (MGC).";
RL Genome Res. 14:2121-2127(2004).
CC -!- FUNCTION: Transcription factor that binds to the octamer motif (5'-
CC ATTTGCAT-3'). Regulated the expression of a number of genes such as
CC SPRR2A or placental lactogen.
CC -!- SUBCELLULAR LOCATION: Nucleus.
CC -!- ALTERNATIVE PRODUCTS:
CC Event=Alternative splicing; Named isoforms=3;
CC Name=1; Synonyms=Skn-1a;
CC IsoId=Q9UKI9-1; Sequence=Displayed;
CC Name=2;
CC IsoId=Q9UKI9-2; Sequence=VSP_043900;
CC Name=3; Synonyms=Skn-1n;
CC IsoId=Q9UKI9-3; Sequence=VSP_043901;
CC -!- TISSUE SPECIFICITY: Specifically expressed in epidermis and cultured
CC keratinocytes.
CC -!- MISCELLANEOUS: [Isoform 3]: Specifically expressed in keratinocytes,
CC induced by high calcium concentration. {ECO:0000305}.
CC -!- SIMILARITY: Belongs to the POU transcription factor family. Class-2
CC subfamily. {ECO:0000305}.
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DR EMBL; AF162278; AAF00199.1; -; mRNA.
DR EMBL; AF133895; AAD55245.1; -; mRNA.
DR EMBL; AJ012214; CAB45383.1; -; mRNA.
DR EMBL; AK291993; BAF84682.1; -; mRNA.
DR EMBL; AK302212; BAG63569.1; -; mRNA.
DR EMBL; AP000679; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR EMBL; AP001150; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR EMBL; BC101649; AAI01650.1; -; mRNA.
DR CCDS; CCDS58190.1; -. [Q9UKI9-2]
DR CCDS; CCDS8431.1; -. [Q9UKI9-1]
DR RefSeq; NP_001231611.1; NM_001244682.1. [Q9UKI9-2]
DR RefSeq; NP_055167.2; NM_014352.3. [Q9UKI9-1]
DR RefSeq; XP_011541041.1; XM_011542739.2. [Q9UKI9-3]
DR RefSeq; XP_011541042.1; XM_011542740.2. [Q9UKI9-3]
DR AlphaFoldDB; Q9UKI9; -.
DR SMR; Q9UKI9; -.
DR BioGRID; 117361; 6.
DR IntAct; Q9UKI9; 1.
DR STRING; 9606.ENSP00000260264; -.
DR GlyGen; Q9UKI9; 1 site, 1 O-linked glycan (1 site).
DR iPTMnet; Q9UKI9; -.
DR PhosphoSitePlus; Q9UKI9; -.
DR BioMuta; POU2F3; -.
DR DMDM; 311033416; -.
DR jPOST; Q9UKI9; -.
DR MassIVE; Q9UKI9; -.
DR MaxQB; Q9UKI9; -.
DR PaxDb; Q9UKI9; -.
DR PeptideAtlas; Q9UKI9; -.
DR PRIDE; Q9UKI9; -.
DR ProteomicsDB; 84796; -. [Q9UKI9-1]
DR ProteomicsDB; 84797; -. [Q9UKI9-2]
DR ProteomicsDB; 84798; -. [Q9UKI9-3]
DR Antibodypedia; 18868; 130 antibodies from 29 providers.
DR DNASU; 25833; -.
DR Ensembl; ENST00000260264.8; ENSP00000260264.4; ENSG00000137709.10. [Q9UKI9-2]
DR Ensembl; ENST00000543440.7; ENSP00000441687.2; ENSG00000137709.10. [Q9UKI9-1]
DR GeneID; 25833; -.
DR KEGG; hsa:25833; -.
DR MANE-Select; ENST00000543440.7; ENSP00000441687.2; NM_014352.4; NP_055167.2.
DR UCSC; uc001pxc.4; human. [Q9UKI9-1]
DR CTD; 25833; -.
DR DisGeNET; 25833; -.
DR GeneCards; POU2F3; -.
DR HGNC; HGNC:19864; POU2F3.
DR HPA; ENSG00000137709; Tissue enriched (skin).
DR MIM; 607394; gene.
DR neXtProt; NX_Q9UKI9; -.
DR OpenTargets; ENSG00000137709; -.
DR PharmGKB; PA134963258; -.
DR VEuPathDB; HostDB:ENSG00000137709; -.
DR eggNOG; KOG3802; Eukaryota.
DR GeneTree; ENSGT00940000157627; -.
DR HOGENOM; CLU_013065_2_0_1; -.
DR InParanoid; Q9UKI9; -.
DR OMA; NLEPMHT; -.
DR OrthoDB; 873012at2759; -.
DR PhylomeDB; Q9UKI9; -.
DR TreeFam; TF316413; -.
DR PathwayCommons; Q9UKI9; -.
DR SignaLink; Q9UKI9; -.
DR BioGRID-ORCS; 25833; 15 hits in 1091 CRISPR screens.
DR ChiTaRS; POU2F3; human.
DR GeneWiki; POU2F3; -.
DR GenomeRNAi; 25833; -.
DR Pharos; Q9UKI9; Tbio.
DR PRO; PR:Q9UKI9; -.
DR Proteomes; UP000005640; Chromosome 11.
DR RNAct; Q9UKI9; protein.
DR Bgee; ENSG00000137709; Expressed in skin of abdomen and 124 other tissues.
DR ExpressionAtlas; Q9UKI9; baseline and differential.
DR Genevisible; Q9UKI9; HS.
DR GO; GO:0000785; C:chromatin; ISA:NTNU_SB.
DR GO; GO:0005829; C:cytosol; IDA:HPA.
DR GO; GO:0016604; C:nuclear body; IDA:HPA.
DR GO; GO:0005730; C:nucleolus; IDA:HPA.
DR GO; GO:0005654; C:nucleoplasm; IDA:HPA.
DR GO; GO:0005634; C:nucleus; IDA:MGI.
DR GO; GO:0005886; C:plasma membrane; IDA:HPA.
DR GO; GO:0001228; F:DNA-binding transcription activator activity, RNA polymerase II-specific; IDA:NTNU_SB.
DR GO; GO:0000981; F:DNA-binding transcription factor activity, RNA polymerase II-specific; ISA:NTNU_SB.
DR GO; GO:0000978; F:RNA polymerase II cis-regulatory region sequence-specific DNA binding; IMP:NTNU_SB.
DR GO; GO:0043565; F:sequence-specific DNA binding; IDA:MGI.
DR GO; GO:1990837; F:sequence-specific double-stranded DNA binding; IDA:ARUK-UCL.
DR GO; GO:0008544; P:epidermis development; TAS:ProtInc.
DR GO; GO:0043922; P:negative regulation by host of viral transcription; IDA:UniProtKB.
DR GO; GO:0045944; P:positive regulation of transcription by RNA polymerase II; IDA:NTNU_SB.
DR GO; GO:0006357; P:regulation of transcription by RNA polymerase II; IBA:GO_Central.
DR CDD; cd00086; homeodomain; 1.
DR Gene3D; 1.10.260.40; -; 1.
DR InterPro; IPR009057; Homeobox-like_sf.
DR InterPro; IPR017970; Homeobox_CS.
DR InterPro; IPR001356; Homeobox_dom.
DR InterPro; IPR010982; Lambda_DNA-bd_dom_sf.
DR InterPro; IPR013847; POU.
DR InterPro; IPR000327; POU_dom.
DR InterPro; IPR000972; TF_octamer.
DR Pfam; PF00046; Homeodomain; 1.
DR Pfam; PF00157; Pou; 1.
DR PRINTS; PR00029; OCTAMER.
DR PRINTS; PR00028; POUDOMAIN.
DR SMART; SM00389; HOX; 1.
DR SMART; SM00352; POU; 1.
DR SUPFAM; SSF46689; SSF46689; 1.
DR SUPFAM; SSF47413; SSF47413; 1.
DR PROSITE; PS00027; HOMEOBOX_1; 1.
DR PROSITE; PS50071; HOMEOBOX_2; 1.
DR PROSITE; PS00035; POU_1; 1.
DR PROSITE; PS00465; POU_2; 1.
DR PROSITE; PS51179; POU_3; 1.
PE 2: Evidence at transcript level;
KW Alternative splicing; DNA-binding; Homeobox; Nucleus; Reference proteome;
KW Transcription; Transcription regulation.
FT CHAIN 1..436
FT /note="POU domain, class 2, transcription factor 3"
FT /id="PRO_0000100717"
FT DOMAIN 183..257
FT /note="POU-specific"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00530"
FT DNA_BIND 281..340
FT /note="Homeobox"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00108"
FT REGION 1..40
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 140..186
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 256..278
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 363..421
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 19..35
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 257..274
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 373..421
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT VAR_SEQ 1..9
FT /note="MVNLESMHT -> MESPRTAKGGR (in isoform 2)"
FT /evidence="ECO:0000303|PubMed:14702039"
FT /id="VSP_043900"
FT VAR_SEQ 1..9
FT /note="MVNLESMHT -> MNDAK (in isoform 3)"
FT /evidence="ECO:0000305"
FT /id="VSP_043901"
FT VARIANT 152
FT /note="H -> R (in dbSNP:rs7110845)"
FT /evidence="ECO:0000269|PubMed:10473598,
FT ECO:0000269|PubMed:14702039, ECO:0000269|Ref.2"
FT /id="VAR_031618"
FT VARIANT 390
FT /note="R -> K (in dbSNP:rs2282537)"
FT /evidence="ECO:0000269|PubMed:14702039"
FT /id="VAR_055906"
FT CONFLICT 6
FT /note="S -> P (in Ref. 3; CAB45383)"
FT /evidence="ECO:0000305"
FT CONFLICT 37
FT /note="N -> K (in Ref. 2; AAD55245)"
FT /evidence="ECO:0000305"
FT CONFLICT 351
FT /note="V -> D (in Ref. 1; AAF00199)"
FT /evidence="ECO:0000305"
SQ SEQUENCE 436 AA; 47432 MW; CFF7F0153F0B7589 CRC64;
MVNLESMHTD IKMSGDVADS TDARSTLSQV EPGNDRNGLD FNRQIKTEDL SDSLQQTLSH
RPCHLSQGPA MMSGNQMSGL NASPCQDMAS LHPLQQLVLV PGHLQSVSQF LLSQTQPGQQ
GLQPNLLPFP QQQSGLLLPQ TGPGLASQAF GHPGLPGSSL EPHLEASQHL PVPKHLPSSG
GADEPSDLEE LEKFAKTFKQ RRIKLGFTQG DVGLAMGKLY GNDFSQTTIS RFEALNLSFK
NMCKLKPLLE KWLNDAESSP SDPSVSTPSS YPSLSEVFGR KRKKRTSIET NIRLTLEKRF
QDNPKPSSEE ISMIAEQLSM EKEVVRVWFC NRRQKEKRIN CPVATPIKPP VYNSRLVSPS
GSLGPLSVPP VHSTMPGTVT SSCSPGNNSR PSSPGSGLHA SSPTASQNNS KAAVNSASSF
NSSGSWYRWN HSTYLH
